rpmjResearch'n Practical Medicine JournalResearch and Practical Medicine Journal2410-1893"QUASAR", LLC10.17709/2409-2231-2015-2-77rpmj-109Research ArticleОбзоры, лекцииReviews, lecturesПРОБЛЕМЫ СЕРДЕЧНО-СОСУДИСТЫХ ОСЛОЖНЕНИЙ, ИНДУЦИРОВАННЫХ ХИМИОТЕРАПИЕЙ И ТАРГЕТНЫМИ ПРЕПАРАТАМИCARDIOVASCULAR COMPLICATIONS CAUSED BY CHEMOTHERAPY AND TARGETED AGENTSБолотинаЛ. В.BolotinaL. V.

д.м.н., заведующая отделением химиотерапии МНИОИ им. П.А.Герцена – филиала ФГБУ «НМИРЦ» Минздрава России

PhD, MD, head of the chemotherapy Department of P. Hertsen MORI

ОвчинниковА. Г.OvchinnikovA. G.

д.м.н., заведующий лабораторией функциональной диагностики НДО НИИ кардиологии им. А.Л.Мясникова ФГБУ РКНПК МЗ РФ

PhD, MD, head of department of functional diagnostics, SDD A.L. Myasnikov cardiological RC FSBO RCCPC HM RF

МНИОИ им. П.А.Герцена – филиал ФГБУ «НМИРЦ» Минздрава России (Москва, Россия) 125284, Россия, Москва, 2-й Боткинский проезд, 3РоссияP.Hertsen Moscow Oncology Research Institute – b ranch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation (Moscow, Russia) 2nd Botkinskiy proezd 3, Moscow, 125284, RussiaRussian FederationНДО НИИ кардиологии им. А.Л.Мясникова ФГБУ РКНПК МЗ РФ , (Москва, Россия) 121552, Россия, Москва, ул. 3-я Черепковская, 15аРоссияCardiology Reasearch Institute A.L.Myasnikov – branch of the Russian Cardiology Research-and-Production Centre of the Ministry of Health of the Russian Federation (Moscow, Russia) 3rd Cherepkovskaya 15a, Moscow, 121552, RussiaRussian Federation20153112201524106114Copyright © Болотина Л.В., Овчинников А.Г., 20162016Болотина Л.В., Овчинников А.Г.Bolotina L.V., Ovchinnikov A.G.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpmj.ru/rpmj/article/view/109

Современная лекарственная терапия существенно увеличила продолжительность жизни больных раком молочной железы, в связи с чем существенное значение приобретает ее качество. Кардиальная токсичность ряда цитостатиков может проявляться спустя годы после завершения терапии. Наиболее часто вклад в развитие кардиотоксичности вносят антрациклиновые антибиотики. Повторное их использование ограничивается суммарной дозой. Комбинация антрациклинов с трастузумабом увеличивает риск развития кардиотоксичности. Использование пегилированной липосомальной формы антрациклинов, своевременное выявление фоновых заболеваний, а также проведение профилактических мероприятий может позволить снизить риск развития этого грозного осложнения.

Modern-day drug therapy has significantly increased the life expectancy of patients with breast cancer, therefore now this is the quality if the therapy itself which is of major importance. Cardiac toxicity of some cytostatics may come out in years after the therapy. Anthracycline antibiotics are considered to be the main factor leading to cardiotoxicity. In case of recurrent use of anthracycline antibiotics, the overall dose of these should have to be limited. The combination of anthracyclines with trastuzumab increases essentially the risk of cardiotoxicity. To reduce the risk of developing such severe epiphenomenon it is recommended to use pegylated liposomal forms of anthracyclines, to detect background diseases in due time, as well as to generally take preventive actions.

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The authors declare that there are no conflicts of interest present.