rpmjResearch'n Practical Medicine JournalResearch and Practical Medicine Journal2410-1893"QUASAR", LLC10.17709/2410-1893-2026-13-2-8EHSYGTrpmj-1249Research ArticleОбзорReviewСтандартизированный алгоритм построения радиомических моделей МРТ для диагностики рака предстательной железы Grade Group ≥ 1 и ≥ 3: рекомендации на основе систематического обзора, метаанализа и оценки методологического качества (RQS/METRICS)Standardized algorithm for developing MRI-based radiomics models for detecting Grade Group ≥ 1 and ≥ 3 prostate cancer: recommendations from a systematic review, meta-analysis, and methodological quality assessment (RQS/METRICS)https://orcid.org/0000-0001-6483-2074КрючковаО. В.KryuchkovaO. V.

 

Крючкова Оксана Валентиновна – к.м.н., врач-рентгенолог, заведующая отделением рентгеновской диагностики и компьютерной томографии ФГБУ «Центральная клиническая больница с поликлиникой» Управления делами президента Российской Федерации, г. Москва, Российская Федерация; доцент кафедры лучевой диагностики и терапии ФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента Российской Федерации, г. Москва, Российская Федерация

ORCID: https://orcid.org/0000-0001-6483-2074, eLibrary SPIN: 2445-3370, AuthorID: 1230036, Scopus Author ID: 57217874860

 

Oksana V. Kryuchkova – Cand. Sci. (Medicine), Radiologist, Head of the Department of Radiology and Computed Tomography, Central Clinical Hospital, Moscow, Russian Federation; Associate Professor, Department of Diagnostic Radiology and Radiation Therapy., Central State Medical Academy, Moscow, Russian Federation

ORCID: https://orcid.org/0000-0001-6483-2074, eLibrary SPIN: 2445-3370, AuthorID: 1230036, Scopus Author ID: 57217874860

ovk16@bk.ruhttps://orcid.org/0000-0002-2079-1482ЩепкинаЕ. В.SchepkinaE. V.

 

Щепкина Елена Викторовна – к.социол.н., главный специалист, заместитель начальника отдела по сводному контингенту и статистике ФГБУ ВО «Российская академия народного хозяйства и государственной службы при Президенте РФ», г. Москва, Российская Федерация; аналитик ГБУЗ «Научно-практический клинический центр диагностики и телемедицинских технологий Департамента здравоохранения г. Москвы, г. Москва, Российская Федерация

ORCID: https://orcid.org/0000-0002-2079-1482, eLibrary SPIN: 2347-9436, AuthorID: 959277, Scopus Author ID: 57211515165, WoS ResearcherID: IAR-4060-2023

 

Elena V. Schepkina – Cand. Sci. (Sociology), Chief Specialist, Deputy Head of the Department for Consolidated Personnel Registry and Statistics, Russian Presidential Academy of National Economy and Public Administration, Moscow, Russian Federation; Analyst, Research and Practical Clinical Center for Diagnostics and Telemedical Technologies, Moscow, Russian Federation

ORCID: https://orcid.org/0000-0002-2079-1482, eLibrary SPIN: 2347-9436, AuthorID: 959277, Scopus Author ID: 57211515165, WoS ResearcherID: IAR-4060-2023

elenaschepkina@gmail.comhttps://orcid.org/0000-0003-2182-5792КузнецовА. И.KuznetsovA. I.

 

Кузнецов Антон Игоревич – программист, компания Техдепартамент, г. Москва, Российская Федерация

ORCID: https://orcid.org/0000-0003-2182-5792, eLibrary SPIN: 8824-9080, AuthorID: 1198516, Scopus Author ID: 57222512467

 

 

Anton I. Kuznetsov – Programmer, TechDepartment Company, Moscow, Russian Federation

ORCID: https://orcid.org/0000-0003-2182-5792, eLibrary SPIN: 8824-9080, AuthorID: 1198516, Scopus Author ID: 57222512467

drednout5786@yandex.ruhttps://orcid.org/0009-0001-4444-8881ЗаряЕ. В.ZaryaE. V.

 

Заря Елена Владимировна – врач-рентгенолог отделения рентгеновской диагностики и компьютерной томографии ФГБУ «Центральная клиническая больница с поликлиникой» Управления делами президента Российской Федерации, г. Москва, Российская Федерация

ORCID: https://orcid.org/0009-0001-4444-8881, eLibrary SPIN: 9800-8219, AuthorID: 1222625, Scopus Author ID: 59469698700

 

Elena V. Zarya – Radiologist, Department of Radiology and Computed Tomography, Central Clinical Hospital, Moscow, Russian Federation

ORCID: https://orcid.org/0009-0001-4444-8881, eLibrary SPIN: 9800-8219, AuthorID: 1222625, Scopus Author ID: 59469698700

zaryya@yandex.ruhttps://orcid.org/0000-0002-7591-5120ЕпифановаС. В.EpifanovaS. V.

 

Епифанова Светлана Викторовна – к.м.н., врач-рентгенолог ФГБУ «Центральная клиническая больница с поликлиникой» Управления делами президента Российской Федерации, г. Москва, Российская Федерация

ORCID: https://orcid.org/0000-0002-7591-5120, eLibrary SPIN: 9067-5033, AuthorID: 701641, Scopus Author ID: 37123630700

 

 

Svetlana V. Epifanova – Cand. Sci. (Medicine), Radiologist, Central Clinical Hospital, Moscow, Russian Federation

ORCID: https://orcid.org/0000-0002-7591-5120, eLibrary SPIN: 9067-5033, AuthorID: 701641, Scopus Author ID: 37123630700

svepifanova@yandex.ruhttps://orcid.org/0000-0001-8378-4338РубцоваН. А.RubtsovaN. A.

 

Рубцова Наталья Алефтиновна – д.м.н., заведующая отделом лучевой диагностики Московского научно-исследовательского онкологического института им. П. А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации, г. Москва, Российская Федерация

ORCID: https://orcid.org/0000-0001-8378-4338, eLibrary SPIN: 9712-9091, AuthorID: 700892, Scopus Author ID: 15844343600

 

Natalia A. Rubtsova – Dr. Sci. (Medicine), Head of the Department of Radiology, P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre, Moscow, Russian Federation

ORCID: https://orcid.org/0000-0001-8378-4338, eLibrary SPIN: 9712-9091, AuthorID: 700892, Scopus Author ID: 15844343600

rna17@yandex.ruhttps://orcid.org/0000-0002-3398-4128АлексеевБ. Я.AlekseevB. Ya.

 

Алексеев Борис Яковлевич – д.м.н., профессор, заместитель генерального директора по науке ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации, г. Обнинск, Российская Федерация

ORCID: https://orcid.org/0000-0002-3398-4128, eLibrary SPIN: 4692-5705, AuthorID: 651796, Scopus Author ID: 16023947400, WoS ResearcherID: O-1008-2017

 

Boris Ya. Alekseev – Dr. Sci. (Medicine), Professor, Deputy Director General for Research, National Medical Research Radiological Centre, Obninsk, Russian Federation

ORCID: https://orcid.org/0000-0002-3398-4128, eLibrary SPIN: 4692-5705, AuthorID: 651796, Scopus Author ID: 16023947400, WoS ResearcherID: O-1008-2017

byalekseev@mail.ruhttps://orcid.org/0000-0002-3521-8937ТалышинскийА. Э.TalyshinskiiA. E.

 

Талышинский Али Эльманович – д.м.н., уролог-андролог, врач ультразвуковой диагностики ФГБОУ ВО «Санкт-Петербургский государственный университет», г. Санкт-Петербург, Российская Федерация

ORCID: https://orcid.org/0000-0002-3521-8937, eLibrary SPIN: 7747-0117, AuthorID: 1097817, Scopus Author ID: 57216868363, WoS ResearcherID: AFQ-8161-2022

 

Ali E. Talyshinskii – Dr. Sci. (Medicine), Urologist-Andrologist, Ultrasound Specialist, Saint Petersburg State University, Saint Petersburg, Russian Federation

ORCID: https://orcid.org/0000-0002-3521-8937, eLibrary SPIN: 7747-0117, AuthorID: 1097817, Scopus Author ID: 57216868363, WoS ResearcherID: AFQ-8161-2022

ali-ma@mail.ruЦентральная клиническая больница с поликлиникой Управления делами президента Российской Федерации, г. Москва, Российская Федерация <p> Центральная государственная медицинская академия Управления делами Президента Российской Федерации, г. Москва, Российская ФедерацияCentral Clinical Hospital, Moscow, Russian Federation <p> Central State Medical Academy, Moscow, Russian FederationРоссийская академия народного хозяйства и государственной службы при Президенте РФ, г. Москва, Российская Федерация <p> Научно-практический клинический центр диагностики и телемедицинских технологий Департамента здравоохранения г. Москвы, г. Москва, Российская ФедерацияRussian Presidential Academy of National Economy and Public Administration, Moscow, Russian Federation <p> Research and Practical Clinical Center for Diagnostics and Telemedical Technologies, Moscow, Russian FederationМосковский авиационный институт (национальный исследовательский университет)<p> г. Москва, Российская ФедерацияMoscow Aviation Institute (National Research University) <p> Moscow, Russian FederationЦентральная клиническая больница с поликлиникой Управления делами президента Российской Федерации <p> г. Москва, Российская ФедерацияCentral Clinical Hospital <p> Moscow, Russian FederationЦентральная клиническая больница с поликлиникой Управления делами президента Российской Федерации, г. Москва, Российская Федерация <p> Научно-практический клинический центр диагностики и телемедицинских технологий Департамента здравоохранения г. Москвы, г. Москва, Российская ФедерацияCentral Clinical Hospital, Moscow, Russian Federation <p> Research and Practical Clinical Center for Diagnostics and Telemedical Technologies, Moscow, Russian FederationМосковский научно-исследовательский онкологический институт им. П. А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации <p> г. Москва, Российская ФедерацияP. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre <p> Moscow, Russian FederationНациональный медицинский исследовательский центр радиологии Министерства здравоохранения Российской Федерации <p> г. Москва, Российская ФедерацияNational Medical Research Radiological Centre <p> Obninsk, Russian FederationСанкт-Петербургский государственный университет <p> г. Санкт-Петербург, Российская ФедерацияSaint Petersburg State University <p> Saint Petersburg, Russian Federation202623062026132104120Copyright &#x00A9; Крючкова О.В., Щепкина Е.В., Кузнецов А.И., Заря Е.В., Епифанова С.В., Рубцова Н.А., Алексеев Б.Я., Талышинский А.Э., 20262026Крючкова О.В., Щепкина Е.В., Кузнецов А.И., Заря Е.В., Епифанова С.В., Рубцова Н.А., Алексеев Б.Я., Талышинский А.Э.Kryuchkova O.V., Schepkina E.V., Kuznetsov A.I., Zarya E.V., Epifanova S.V., Rubtsova N.A., Alekseev B.Y., Talyshinskii A.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpmj.ru/rpmj/article/view/1249Цель исследования

Цель исследования. На основе синтеза данных систематического обзора в рамках типовой методологии проведения метаанализов оценить текущее состояние разработки радиомических моделей, проанализировать источники методологической неоднородности и представить стандартизированный, доказательно обоснованный алгоритм для повышения качества и воспроизводимости будущих исследований.

Материалы и методы

Материалы и методы. Проведен систематический поиск в базах PubMed/MEDLINE, Embase, Scopus, Web of Science и Cochrane Library за период 01.2020–12.2025. Использовались ключевые слова, связанные с радиомикой, МРТ и раком поджелудочной железы (РПЖ). По критериям PICOS было отобрано 27 исследований (n = 5945 пациентов). Диагностическая эффективность оценена с помощью метаанализа (модель случайных эффектов), методологическое качество – по шкалам RQS и METRICS двумя независимыми рецензентами.

Результаты

Результаты. Включено 27 исследований. Объединенная диагностическая эффективность радиомических моделей высокая (AUC = 0.847), однако отмечена существенная гетерогенность (I² = 70.32 %). Среднее качество по RQS составило 15,2 ± 3,4 (42,3 % от максимума), по METRICS – 67,5 ± 9,0 %. Выявлены системные методологические слабости: ретроспективный дизайн (96,3 %), отсутствие внешней валидации (77,8 %), анализа клинической полезности (70 %) и описания обработки пропущенных данных (100 %). Мета-регрессия показала, что высокий риск смещения приводит к завышению AUC (p = 0,009).

Заключение

Заключение. Текущие высокие показатели эффективности радиомики РПЖ требуют осторожной интерпретации из-за методологических ограничений. Разработанный стандартизированный алгоритм, включающий рекомендации по проспективному дизайну, валидации, обработке данных и построению модели, представляет собой практическое методологическое руководство. Его внедрение может стать ключом к повышению методологической строгости, воспроизводимости и клинической трансляционной ценности будущих исследований в данной области.

Purpose of the study

Purpose of the study. Based on a synthesis of systematic review data using standard meta-analysis methodology, to evaluate the current state of radiomics model development, analyze sources of methodological heterogeneity, and present a standardized evidence-based algorithm to improve the quality and reproducibility of future studies.

Materials and methods

Materials and methods. A systematic search was conducted in the PubMed/MEDLINE, Embase, Scopus, Web of Science, and Cochrane Library databases for studies published between January 2020 and December 2025. Keywords related to radiomics, magnetic resonance imaging (MRI), and prostate cancer (PCa) were used. According to the PICOS criteria, 27 studies involving 5,945 patients were included. Diagnostic performance was assessed using a random-effects meta-analysis, while methodological quality was evaluated independently by two reviewers using the Radiomics Quality Score (RQS) and METRICS instruments.

Results

Results. Twenty-seven studies were included. The pooled diagnostic performance of radiomics models was high (AUC = 0.847); however, substantial heterogeneity was observed (I² = 70.32 %). The mean RQS score was 15.2 ± 3.4 (42.3 % of the maximum possible score), while the mean METRICS score was 67.5 ± 9.0 %. Systematic methodological weaknesses were identified, including retrospective study design (96.3 %), lack of external validation (77.8 %), absence of clinical utility assessment (70 %), and failure to report missing-data handling procedures (100 %). Meta-regression demonstrated that a high risk of bias was associated with inflated AUC estimates (p = 0.009).

Conclusion

Conclusion. The currently reported high performance of PCa radiomics models should be interpreted with caution because of methodological limitations. The proposed standardized algorithm, incorporating recommendations on prospective study design, validation, data processing, and model development, provides a practical methodological guidance for future research. Its implementation may be key to improving methodological rigor, reproducibility, and the clinical translational value of future studies in this field.

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The authors declare that there are no conflicts of interest present.