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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rpmj</journal-id><journal-title-group><journal-title xml:lang="ru">Research'n Practical Medicine Journal</journal-title><trans-title-group xml:lang="en"><trans-title>Research and Practical Medicine Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2410-1893</issn><publisher><publisher-name>"QUASAR", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17709/2409-2231-2016-3-3-3</article-id><article-id custom-type="elpub" pub-id-type="custom">rpmj-148</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Оригинальные статьи. Маммология</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Original Articles. Mammalogy</subject></subj-group></article-categories><title-group><article-title>СТРУКТУРА ПИТАНИЯ И РИСК РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ</article-title><trans-title-group xml:lang="en"><trans-title>THE DIETARY PATTERNS AND THE RISK OF BREAST CANCER</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0827-9451</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Радкевич</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Radkevich</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. б.н., профессор, заместитель по научной работе ФГБУН «Центр теоретических проблем физико-химической фармакологии РАН» </p></bio><bio xml:lang="en"><p>MD, professor, Deputy director on scientific, Center for Theoretical Problems of Physicochemical Pharmacology, Institution of Russian Academy of Sciences</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6299-662X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Радкевич</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Radkevich,</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>инженер-исследователь ФГБУН «Центр теоретических проблем физико-химической фармакологии РАН»</p></bio><bio xml:lang="en"><p>research engineer, Center for Theoretical Problems of Physicochemical Pharmacology, Institution of Russian Academy of Sciences</p></bio><email xlink:type="simple">rlactp@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУН «Центр теоретических проблем физико-химической фармаколог ии РАН»; 119991, Россия, Москва, ул. Косыгина, 4</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Center for Theoretical Problems of Physicochemical Pharmacology, Institution of Russian Academy of Sciences; 4, ul. Kosygina, Moscow, 119991, Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>20</day><month>09</month><year>2016</year></pub-date><volume>3</volume><issue>3</issue><fpage>30</fpage><lpage>41</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Радкевич Л.А., Радкевич Д.А., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Радкевич Л.А., Радкевич Д.А.</copyright-holder><copyright-holder xml:lang="en">Radkevich L.A., Radkevich, D.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpmj.ru/rpmj/article/view/148">https://www.rpmj.ru/rpmj/article/view/148</self-uri><abstract><p>Нарастающую частоту неинфекционных хронических заболеваний (НИЗ) в мире связывают с влиянием внешних факторов, в том числе с нерациональным питанием и ожирением.</p><sec><title>Цель исследования</title><p>Цель исследования. В работе проведены сравнительные исследования структуры питания в странах с одинаковыми социальными условиями, но с разной частотой рака молочной железы (РМЖ).</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Сведения о заболеваемости РМЖ в 160 странах мира собраны из базы GLOBOCAN за 2008 г. Уровни потребления продуктов и нутриентов (53 вида) для каждой страны выбраны из базы FAO за 1990–2005 и 2003–2005 гг. Структуру питания стран представляли в виде общего суточного уровня потребления (ОУП) (г/чел./день), а также в виде блоков продуктов, объединенных общим источником происхождения (г/чел./день): «продукты животных», «зерна, овощи», «фрукты, напитки», «алкогольные напитки»; «нутриенты животных продуктов» (%): энергия, протеин, жир; «полные нутриенты» (%): углеводы, протеины, жиры; энергия (ккал/чел./день), протеины и жиры (г/чел/день). Определяли процентный вклад каждого блока структуры питания в ОУП. В сравнительном анализе использовали также предикторы метаболического синдрома: индекс массы тела (ИМТ ≥ 25 кг/м2) и уровень холестерина крови (УХл ≥ 50 ммол/л).</p></sec><sec><title>Результаты</title><p>Результаты. При сходных социальных и географических условиях в странах с высокой заболеваемостью РМЖ состав структуры питания был представлен: 36% – «продукты животных», 37% – «зерна и овощи», 14% – «фрукты и напитки», 13% – «алкогольные напитки». В странах Средиземноморья с низкой частотой РМЖ: 28% – «продукты животных», 55% – «зерна и овощи», 11% – «фрукты и напитки», 5% – «алкогольные напитки». В странах с высокой заболеваемостью РМЖ нутриентов «животных продуктов» в 1,5 раза больше, чем в странах Средиземноморья с низкой частотой РМЖ.</p></sec><sec><title>Заключение</title><p>Заключение. Структура питания оказывает модифицирующее влияние на риск развития РМЖ.</p></sec></abstract><trans-abstract xml:lang="en"><p>Malnutrition in the early stages of life cause hypomotilinemia and shape the epigenome, and does not change the genetic code. Increasing the frequency of non-communicable chronic diseases (NCDS) in the world associated with influence of external factors, including poor diet and obesity .</p><sec><title>Purpose</title><p>Purpose. A comparative study of dietary patterns in countries with similar social conditions but with different frequency of breast cancer.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. Data on incidence of breast cancer in 160 countries is selected from the database GLOBOCAN 2008. Levels of consumption of food and nutrients (53 species) for each country selected from the FAO database for 1990–2005 and 2003–2005 years. The power structure of countries were represented in the form of a total daily level of consumption (DLC) (g/person/day), and also in the form of blocks of products with common source of origin (g/person/day): animal products, grains, vegetables”, “fruit drinks”, “alcoholic beverages”; “nutrients of animal products” (%): energy, protein, fat; “full of nutrients” (%): carbohydrates, proteins, fats; energy (kcal/person/day), proteins and fats (g/person/day). Determined the percent contribution of each block in the structure of food in the total daily consumption of food and nutrients (DLC). In the comparative analysis used as a predictor of the metabolic syndrome: body mass index (BMI ≥ 25 kg/m2) and blood cholesterol (NF ≥ 50 mmol/l).</p></sec><sec><title>Results</title><p>Results. Under similar social and geographical conditions in countries with a high incidence of breast cancer part of the power Structure were represented: 36% of “animal products”, 37% “of grain and vegetables,” 14% “fruits and beverages”, 13% “alcoholic beverages”. In the Mediterranean countries with a low incidence of breast cancer: 28% of “animal products”, 55% “grain &amp; vegetables 11% fruits &amp; drink”, 5% “alcoholic beverages”. In countries with a high incidence of breast cancer Nutrients “animal products” in 1,5 times more than in the Mediterranean countries with a low incidence of breast cancer.</p></sec><sec><title>Conclusions</title><p>Conclusions. The food pattern has modifying effects on the risk of breast cancer.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>средиземноморская диета</kwd><kwd>частота РМЖ</kwd><kwd>структура питания</kwd><kwd>уровни потребления продуктов и нутриентов</kwd><kwd>метаболический синдром</kwd></kwd-group><kwd-group xml:lang="en"><kwd>mediterranean diet</kwd><kwd>the frequency of breast cancer</kwd><kwd>dietary patterns</kwd><kwd>levels of consumption of food and nutrients</kwd><kwd>the metabolic syndrome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Fung T. T., Hu F. B., Holmes M. D., Rosner B. A., Hunter D. J., Colditz G. A., et al. Dietary patterns and the risk of postmenopausal breast cancer. Int J Cancer. 2005;116 (1):116–21. DOI: 0.1002/ijc.20999</mixed-citation><mixed-citation xml:lang="en">Fung T. T., Hu F. B., Holmes M. D., Rosner B. A., Hunter D. J., Colditz G. 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