rpmjResearch'n Practical Medicine JournalResearch and Practical Medicine Journal2410-1893"QUASAR", LLC10.17709/2409-2231-2016-3-3-8rpmj-153Research ArticleОбзорыReviewВОЗМОЖНОСТИ HIFU-ТЕРАПИИ НА СОВРЕМЕННОМ ЭТАПЕTHE POSSIBILITY OF HIFU THERAPY AT THE PRESENT STAGEСулеймановЭ. А.SuleimanovE. A.

к. м.н., главный врач ГБУ «Республиканский онкологический диспансер»

PhD, head doctor of Republican oncologic dispensary

ФилоненкоЕ. В.FilonenkoE. V.

д. м.н., профессор, руководитель Центра лазерной и фотодинамической диагностики и терапии опухолей МНИОИ им. П. А. Герцена – филиал ФГБУ «НМИРЦ» Минздрава России

MD, professor, head of the Center of laser and photodynamic diagnostics and therapy of tumors, P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation

derkul23@yandex.ruhttps://orcid.org/0000-0002-5750-8492МосквичеваЛ. И.MoskvichevaL. I.

лаборант-исследователь Центра лазерной и фотодинамической диагностики и терапии опухолей МНИОИ им. П. А. Герцена – филиал ФГБУ «НМИРЦ» Минздрава России

laboratory researcher of the Center of laser and photodynamic diagnostics and therapy of tumors, P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation

https://orcid.org/0000-0001-8784-8415КапринА. Д.KaprinA. D.

член-корреспондент РАН, д. м.н., профессор, заведующий кафедрой урологии и оперативной нефрологии с курсом онкоурологии Медицинского института РУДН, генеральный директор ФГБУ «НМИРЦ» Минздрава России

corr. Member of RAS, PhD, MD, Prof.; Corr. member of the Russian Academy of Education; Honored Physician of the Russian Federation; General Director of National Medical Research Radiological Centre, Head of Department of Urology with Course of Urological Oncology, Faculty for Postgraduate Training, Peoples’ Friendship University of Russia

https://orcid.org/0000-0002-0792-6012КостинА. А.KostinA. A.

д. м.н., профессор, первый заместитель генерального директора ФГБУ «НМИРЦ» Минздрава России

MD, professor, first deputy general director, National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation

СамсоновЮ. В.SamsonovYu. V.

к. м.н., ведущий научный сотрудник Российского центра информационных технологий и эпидемиологических исследований в онкологии МНИОИ им. П. А. Герцена – филиал ФГБУ «НМИРЦ» Минздрава России

PhD, leading researcher of RCITEO, P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation

ИсаевА. Р.IsaevA. R.

врач-хирург отделения общей онкологии МНИОИ им. П. А. Герцена – филиал ФГБУ «НМИРЦ» Минздрава России

surgeon of Department of General Oncology, P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation

ГБУ «Республиканский онкологический диспансер»; 364029, Россия, Чеченская Республика, Грозный, ул. Леонова, 81;РоссияRepublican oncologic dispensary; 81, ul. Leonova, Grozny, Chechnya, 364029Russian FederationМНИОИ им. П.А. Герцена – филиал ФГБУ «НМИРЦ» Минздрава России; 125284, Россия, Москва, 2-й Боткинский проезд, 3РоссияP. Hertsen Moscow Oncology Research Institute – Branch of the Na tional Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; 3, 2 nd Botkinskiy proezd, Moscow, 125284, RussiaRussian Federation201620092016337682Copyright © Сулейманов Э.А., Филоненко Е.В., Москвичева Л.И., Каприн А.Д., Костин А.А., Самсонов Ю.В., Исаев А.Р., 20162016Сулейманов Э.А., Филоненко Е.В., Москвичева Л.И., Каприн А.Д., Костин А.А., Самсонов Ю.В., Исаев А.Р.Suleimanov E.A., Filonenko E.V., Moskvicheva L.I., Kaprin A.D., Kostin A.A., Samsonov Y.V., Isaev A.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpmj.ru/rpmj/article/view/153

К написанию этой статьи подтолкнул возрастающий интерес к технологии высокоинтенсивного сфокусированного ультразвука (high-intensity focused ultrasound, HIFU), который, в свою очередь, связан с широким спектром потенциальных точек применения, минимальной инвазивностью данного метода, минимальным воздействием на организм пациента, характеризуется коротким периодом реабилитации. Также данный метод лечения обладает высокой воспроизводимостью, что, в свою очередь, способствует быстрому распространению HIFU-терапии в практике. Обзор посвящен истории развития, изучения и применения метода ультразвуковой абляции, современным представлениям о методике проведения HIFU-терапии, имеющимся в настоящее время техническим возможностям для проведения неинвазивной высокоинтенсивной фокусированной ультразвуковой терапии, а также демонстрации эффективности проведения данного лечения у пациентов со злокачественными и доброкачественными новообразованиями различной локализации, как в самостоятельном варианте, так и в комплексе с другими вариантами лечения (хирургия, лекарственная терапия, лучевая терапия), попытке систематизации ранних и отдаленных результатов лечения. В статье отображены данные мировой и отечественной литературы. Одним из важных направлений изучения описанной методики является расширение возможных точек применения при различных локализациях злокачественной патологии как локального, так и генерализованного характера поражения. Отдельным пунктом стоит применение HIFU-терапии в лечении хронического болевого синдрома.

Writing this article is prompted by growing interest in the technology of high intensity focused ultrasound (high-intensity focused ultrasound, HIFU), which, in turn, is associated with a wide range of potential points of use, minimal invasiveness of this method, minimal impact on the patient’s body, characterized by a short period of rehabilitation. Also, this treatment method has a high reproducibility, which in turn contributes to the rapid spread of HIFU therapy in practice. The review is devoted to the history of development, study and application of the method of ultrasonic ablation, the modern view on how to conduct HIFU therapy, the currently available technical possibilities for non-invasive high-intensity focused ultrasound therapy as well as demonstrate the effectiveness of this treatment in patients with malignant and benign tumors of different localization, as in a standalone version or in combination with other treatment options (surgery, drug therapy, radiation therapy), an attempt to systematize the early and remote results of treatment. The article represents the data of world and national literature. One of the important directions of the study of the described technique is an expansion of possible application in various malignant pathologies, both local and generalized nature of the lesion. A separate item is the application of HIFU therapy in the treatment of chronic pain syndrome.

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The authors declare that there are no conflicts of interest present.