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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rpmj</journal-id><journal-title-group><journal-title xml:lang="ru">Research'n Practical Medicine Journal</journal-title><trans-title-group xml:lang="en"><trans-title>Research and Practical Medicine Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2410-1893</issn><publisher><publisher-name>"QUASAR", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17709/2409-2231-2017-4-1-8</article-id><article-id custom-type="elpub" pub-id-type="custom">rpmj-174</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клинические наблюдения</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical Case Reports</subject></subj-group></article-categories><title-group><article-title>КЛИНИЧЕСКИЙ ПРИМЕР ИСПОЛЬЗОВАНИЯ ЛИПОФИЛИНГА ПРИ ОТСРОЧЕННЫХ РЕКОНСТРУКЦИЯХ</article-title><trans-title-group xml:lang="en"><trans-title>CLINICAL EXAMPLE OF THE USE OF LIPOFILLING WITH DELAYED RECONSTRUCTION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7141-2502</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зикиряходжаев</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Zikiryakhodzhayev</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>руководитель отделения онкологии и реконструктивно-пластической хирургии молочной железы и кожи, 125284, Москва, 2-й Боткинский проезд, 3;</p><p>119991, Москва, ул. Трубецкая, 8, стр. 2;</p><p>д.м.н., профессор кафедры онкологии и рентгенорадиологии РУДН, 117198, Москва, ул. Миклухо-Маклая, 6</p></bio><bio xml:lang="en"><p>Head of the Department of Oncology and Reconstructive Surgery of the Mammary Gland and Skin, 3, 2nd Botkinskiy proezd, Moscow, 125284;</p><p>8/2 ul. Trubetskaya, Moscow, 119991;</p><p>PhD, MD, Professor of the Department of Oncology and Radiology, 6 ul. Miklukho-Malaya, Moscow 117198</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8265-1848</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Масри</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Masri</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант отделения онкологии и реконструктивно-пластической хирургии молочной железы и кожи,</p><p>125284, Москва, 2-й Боткинский проезд, 3</p></bio><bio xml:lang="en"><p>postgraduate of the Department of Oncology and Reconstructive Surgery of the Mammary Gland and Skin,</p><p>3, 2nd Botkinskiy proezd, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2337-5919</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сухотько</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Sukhotko</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., младший научный сотрудник отделения онкологии и реконструктивно-пластической хирургии молочной железы и кожи,</p><p>125284, Москва, 2-й Боткинский проезд, 3</p></bio><bio xml:lang="en"><p>PhD, junior researcher of the Department of Oncology and Reconstructive Surgery of the Mammary Gland and Skin,</p><p>3, 2nd Botkinskiy proezd, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Усов</surname><given-names>Ф. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Usov</surname><given-names>F. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., младший научный сотрудник отделения онкологии и реконструктивно-пластической хирургии молочной железы и кожи,</p><p>125284, Москва, 2-й Боткинский проезд, 3</p></bio><bio xml:lang="en"><p>PhD, junior researcher of the Department of Oncology and Reconstructive Surgery of the Mammary Gland and Skin,</p><p>3, 2nd Botkinskiy proezd, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1629-0711</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Старкова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Starkova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант отделения онкологии и реконструктивно-пластической хирургии молочной железы и кожи,</p><p>125284, Москва, 2-й Боткинский проезд, 3</p></bio><bio xml:lang="en"><p>postgraduate of the Department of Oncology and Reconstructive Surgery of the Mammary Gland and Skin,</p><p>3, 2nd Botkinskiy proezd, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5025-3378</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ратушная</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ratushnaya</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., научный сотрудник отделения ультразвуковой диагностики,</p><p>125284, Москва, 2-й Боткинский проезд, 3</p></bio><bio xml:lang="en"><p>PhD, researcher of the Ultrasound Department,</p><p>3, 2nd Botkinskiy proezd, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8177-3192</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Евтягина</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Evtyagina</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>клинический ординатор отделения ультразвуковой диагностики,</p><p>125284, Москва, 2-й Боткинский проезд, 3</p></bio><bio xml:lang="en"><p>clinical resident of Ultrasound Department,</p><p>3, 2nd Botkinskiy proezd, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский радиологический центр» Минздрава России;&#13;
ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России;&#13;
ФГАОУВО «Российский университет дружбы народов»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation;&#13;
Sechenov First Moscow State Medical Univesity; &#13;
Peoples Friendship University of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский радиологический центр» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>23</day><month>03</month><year>2017</year></pub-date><volume>4</volume><issue>1</issue><fpage>63</fpage><lpage>67</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Зикиряходжаев А.Д., Масри А.А., Сухотько А.С., Усов Ф.Н., Старкова М.В., Ратушная В.В., Евтягина Н.В., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Зикиряходжаев А.Д., Масри А.А., Сухотько А.С., Усов Ф.Н., Старкова М.В., Ратушная В.В., Евтягина Н.В.</copyright-holder><copyright-holder xml:lang="en">Zikiryakhodzhayev A.D., Masri A.A., Sukhotko A.S., Usov F.N., Starkova M.V., Ratushnaya V.V., Evtyagina N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpmj.ru/rpmj/article/view/174">https://www.rpmj.ru/rpmj/article/view/174</self-uri><abstract><p>Злокачественные опухоли молочных желез являются одной из причин инвалидизации, обусловленной отсутствием молочной железы или наличием операционных дефектов. В большинстве случаев от качества выполненной операции зависит дальнейшее социально-активное поведение пациентки.</p><p>В данной статье представлен клинический случай применения липофилинга при реконструктивно-пластических операциях у больной раком молочной железы после проведенного комплексного лечения. На конкретном примере продемонстрирован положительный эффект после проведенного одного сеанса липофилинга передней грудной стенки справа с использованием аппаратной методики Body-Jet. Целью для проведения данной процедуры было улучшение качества покровных тканей в области п/о рубца на передней грудной стенке справа после проведенного комплексного лечения, включающего также и такой агрессивный для покровных тканей метод лечения, как лучевая терапия.</p><p>Доказано, что мезенхимальные стромальные клетки, или клетки-мессенджеры, присутствующие во всех жировых тканях, способствуют их регенерации путем формирования новых кровеносных сосудов или воздействия непосредственно на поврежденные или подверженные старению структуры — восстанавливают и омолаживают области проведения липофилинга. Поэтому жировая ткань является заложенным природой источником регенерации человеческого тела. На данном клиническом примере после успешно проведенного одного сеанса липофилинга отмечено улучшение качества кожи в области п/о рубца после выполненной мастэктомии и проведенной лучевой терапии. Также зафиксирована хорошая приживаемость аутожирового трансплантата, которого было достаточно для реализации дальнейших этапов реконструкции молочной железы.</p></abstract><trans-abstract xml:lang="en"><p>Malignant breast tumors are one of the causes of disability due to lack of breast or having operational defects. In most cases, the quality of the operation depends on the further social and active patient behavior.</p><p>This article presents a clinical case of the use of lipofilling with reconstructive plastic surgery in breast cancer patients after complex treatment. In the particular example we show the positive effects after one session of conducted lipofiling in front of the chest wall to the right with Body-Jet hardware techniques. The purpose of this procedure was to improve the quality of cover fabrics in postoperative scar on the anterior chest wall right after comprehensive treatment, including also a cover for the such aggressive tissue treatment, as radiotherapy.</p><p>It is proved that mesenchymal stromal cells, or cell-messengers that are present in all the fatty tissues, contribute to its regeneration by forming new blood vessels, or act directly on the damaged or exposed to aging structure — restore and rejuvenate the field of lipofilling. Therefore, adipose tissue is laid down by the nature of the human body a source of regeneration. In this clinical example, after successfully conducted one session of lipofilling marked improvement in skin quality in postoperative scar made after mastectomy and radiotherapy. Good autofat graft survival rate is also fixed, which was enough to implement further stages of breast reconstruction.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак молочной железы</kwd><kwd>липофилинг</kwd><kwd>аутожировой трансплантат</kwd><kwd>отсроченные реконструктивно-пластические операции</kwd><kwd>качество жизни</kwd></kwd-group><kwd-group xml:lang="en"><kwd>lipofilling</kwd><kwd>autofat graft</kwd><kwd>delayed reconstructive plastic surgery</kwd><kwd>quality of life</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Зикиряходжаев А.Д., Волченко А.А., Ермощенкова М.В., Сухотько А.С. Алгоритм выбора реконструктивно-пластических операций у больных раком молочной железы. Поволжский онкологический вестник. 2015; 3: 38–44.</mixed-citation><mixed-citation xml:lang="en">Zikiryakhodzhaev AD, Volchenko AA, Ermoshchenkova MV, Sukhotko AS. 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