rpmjResearch'n Practical Medicine JournalResearch and Practical Medicine Journal2410-1893"QUASAR", LLC10.17709/2409-2231-2017-4-2-4rpmj-184Research ArticleОбзорыReviewНОВЫЕ ТЕХНОЛОГИИ В КРИОХИРУРГИИ ПРИ ЭНДОСКОПИЧЕСКОМ ЛЕЧЕНИИ ОПУХОЛЕЙ ДЫХАТЕЛЬНЫХ ПУТЕЙNEW TECHNOLOGIES IN CRYOSURGERY ENDOSCOPIC TREATMENT OF TUMORS OF THE RESPIRATORY TRACTСоколовВ. В.SokolovV. V.

Соколов Виктор Викторович, доктор медицинских наук, профессор, заведующий эндоскопическим отделением, заслуженный врач РФ, лауреат премии Правительства РФ 

Для корреспонденции: Адрес: 125284, Россия, Москва, 2-й Боткинский проезд, 3

Viktor V. Sokolov, MD, professor, head of endoscopy Department 

For correspondence: Address: 3, 2nd Botkinskiy proezd, Moscow, 125284

profvvs@bk.ruСоколовД. В.SokolovD. V.

Соколов Дмитрий Викторович, доктор медицинских наук, старший научный сотрудник эндоскопического отделения

Dmitriy V. Sokolov, MD, senior researcher of endoscopy Department

ТелегинаЛ. В.TeleginaL. V.

Телегина Лариса Валентиновна, кандидат медицинских наук, старший научный сотрудник эндоскопического отделения

Larisa V. Telegina, PhD, senior researcher of endoscopy Department

НиколаевА. Л.NikolaevA. L.

Николаев Андрей Леонидович, кандидат медицинских наук, научный сотрудник эндоскопического отделения 

Andrey L. Nikolaev, PhD, researcher of endoscopy Department

КирюхинА. П.KirukhinA. P.

Кирюхин Андрей Павлович, кандидат медицинских наук, научный сотрудник эндоскопического отделения

Andrey P. Kirukhin, PhD, researcher of endoscopy Department

КудрявцеваЮ. Л.KudryavtsevaYu. L.

Кудрявцева Юлия Леонидовна, младший научный сотрудник эндоскопического отделения

Yulia L. Kudryavtseva, junior researcher of endoscopy Departmen

Московский научно-исследовательский онкологический институт имени П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский радиологический центр» Минздрава РоссииРоссияP. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationRussian Federation201717062017422936Copyright © Соколов В.В., Соколов Д.В., Телегина Л.В., Николаев А.Л., Кирюхин А.П., Кудрявцева Ю.Л., 20172017Соколов В.В., Соколов Д.В., Телегина Л.В., Николаев А.Л., Кирюхин А.П., Кудрявцева Ю.Л.Sokolov V.V., Sokolov D.V., Telegina L.V., Nikolaev A.L., Kirukhin A.P., Kudryavtseva Y.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpmj.ru/rpmj/article/view/184

В статье представлена история развития метода криохирургии от античности до настоящего времени, материалы клинического использования криохирургии при эндоскопической диагностике и лечении опухолей дыхательных путей на современном этапе, особенности современного оборудования для криохирургии. Также в статье представлен первый клинический опыт использования криореканализации при стенозирующих опухолях трахеобронхиального дерева в России при помощи медицинского аппарата последнего поколения ERBECRYO 2. Приведены три клинических примера криореканализации. Предварительные результаты клинических исследований свидетельствуют, что в сравнении с криохирургией на аппаратах более ранних версий криореканализация при помощи медицинского оборудования последнего поколения и новой модели криозонда является эффективным методом реканализации с целью восстановления проходимости дыхательных путей, который может быть использован в комбинации с электродеструкцией, аргоно-плазменной и лазерной коагуляцией

The article presents the history of the development of the cryosurgery method from antiquity to the present day, materials of the clinical use of cryosurgery for endoscopic diagnosis and treatment of tumors of respiratory tract at the present stage, features of modern equipment for cryosurgery. Also the article presents the first clinical experience of using cryorecanalization in stenosing tumors of the tracheobronchial tree inRussiawith the help of the medical device of the latest generation ERBECRYO 2. Three clinical examples of cryorecanalization are given. Preliminary results of clinical studies show that, in comparison with cryosurgery on older devices, cryorecanalization using the latest generation of m edical eq uipment and a new cryosondond model is an effective method of recanalization to restore airway patency, which can be used in combination with electrodestruction, argon-plasma And laser coagulation.

криохирургиякриореканализациякриобиопсияопухоли дыхательных путейcryosurgerycryocanalizationcryobiopsytumors of the respiratory tractReferencesИонкин Д. А., Кунгурцев С. В., Чжао А. В. Этапы развития криохирургии. Высокотехнологическая медицина. 2014; 1: 4–15.Ionkin DA, Kungurtsev SV, Chzhao AV. Stages of cryosurgery development. Vysokotekhnologicheskaya meditsina. 2014; 1: 4–15. (In Russian).Xu K. History of Cryosurgery. In: Xu K, Korpan NN, Niu L. Modern cryosurgery for cancer. World Scientific; 2012, pp. 3–27.Xu K. History of Cryosurgery. In: Xu K, Korpan NN, Niu L. Modern cryosurgery for cancer. World Scientific; 2012, pp. 3–27.Arnott J. On the treatment of cancer by the regulated application of an anaesthetic temperature. London: Churchill; 1851.Arnott J. On the treatment of cancer by the regulated application of an anaesthetic temperature. London: Churchill; 1851.Bird H. James Arnott, MD (Aberdeen), 1797–1883, a pioneer in refrigeration. Anaesthesia. 1949; 4:10–17.Bird H. James Arnott, MD (Aberdeen), 1797–1883, a pioneer in refrigeration. Anaesthesia 1949; 4:10–17.White AC. Liquid air: its application in medicine and surgery. Med Rec. 1899; 56: 109–12.White AC. Liquid air: its application in medicine and surgery. Med Rec. 1899; 56: 109–12.Pusey W.The use of carbon dioxide snow in the treatment of naevi and other lesions of the skin. JAMA. 1935; 49: 1354–6.Pusey W.The use of carbon dioxide snow in the treatment of naevi and other lesions of the skin. JAMA. 1935; 49: 1354–6.Cooper IS. Cryogenic surgery. A new method of destruction or extirpation of benign or malignant tissues. N Engl J Med. 1963; 263: 741–749.Cooper IS. Cryogenic surgery. A new method of destruction or extirpation of benign or malignant tissues. N Engl J Med. 1963; 263: 741–749.Korpan NN. Pancreas cryosurgery. In: Korpan NN. ed. Basics of Cryosurgery. Wein NewYork: Springer-Verlag, 2001, pp. 151–154.Korpan NN. Pancreas cryosurgery. In: Korpan NN. ed. Basics of Cryosurgery. Wein NewYork: Springer-Verlag, 2001, pp. 151–154.Сперанский А. Д. Элементы построения теории медицины. М.-Л.; 1935.Speranskii AD. Elementy postroeniya teorii meditsiny [Elements of the construction of the theory of medicine]. M.-L.; 1935. (In Russian).Кандель Э. И., Чирешкин Д. Р., Шальников А. И. Итоги развития криохирургии и перспективы дальнейших исследований. Вестник АН СССР. 1978; 3: 3–13.Kandel’ E. I., Chireshkin D. R., Shal’nikov A. I. Itogi razvitiya kriokhirurgii i perspektivy dal’neishikh issledovanii. Vestnik AN SSSR. 1978; 3: 3–13. (In Russian).Sanderson DR, Neel HB, Payne WS, Woolner LB. Cryotherapy for bronchogenic carcinoma: report of a case. Mayo Clin Proc. 1975; 50: 435–437.Sanderson DR, Neel HB, Payne WS, Woolner LB. Cryotherapy for bronchogenic carcinoma: report of a case. Mayo Clin Proc. 1975; 50: 435–437.Maiwand MO, Homasson JP. Cryotherapy for tracheobronchial disorders. Clin Chest Med. 1995; 16: 427.Maiwand MO, Homasson JP. Cryotherapy for tracheobronchial disorders. Clin Chest Med. 1995; 16: 427.Rodgers BM, Moazam F, Talbert JL. Endotracheal cryotherapy in the treatment of refractory airway strictures. Ann Thorac Surg. 1983; 35 (1): 52–57.Rodgers BM, Moazam F, Talbert JL. Endotracheal cryotherapy in the treatment of refractory airway strictures. Ann Thorac Surg. 1983; 35 (1): 52–57.Mathur PN, Wolf KM, Busk MF, et al. Fiberoptic bronchoscopic cryotherapy in the management of tracheobronchial obstruction. Chest. 1996; 110: 718.Mathur PN, Wolf KM, Busk MF, et al. Fiberoptic bronchoscopic cryotherapy in the management of tracheobronchial obstruction. Chest. 1996; 110: 718.Schumann C, Hetzel M, Babiak AJ, Hetzel J, Merk T, Wibmer T, et al. Endobronchial tumor debulking with a flexible cryoprobe for immediate treatment of malignant stenosis. J Thorac Cardiovasc Surg. 2010 Apr; 139 (4): 997–1000. doi: 10.1016/j.jtcvs.2009.06.023Schumann C, Hetzel M, Babiak AJ, Hetzel J, Merk T, Wibmer T, et al. Endobronchial tumor debulking with a flexible cryoprobe for immediate treatment of malignant stenosis. J Thorac Cardiovasc Surg. 2010 Apr;139 (4):997–1000. doi: 10.1016/j.jtcvs.2009.06.023Vergnon JM, Huber RM, Moghissi K. Place of cryotherapy, brachytherapy and photodynamic therapy in therapeutic bronchoscopy of lung cancers. Eur Respir J. 2006; 28 (1): 200–218. DOI: 10.1183/09031936.06.00014006Vergnon JM, Huber RM, Moghissi K. Place of cryotherapy, brachytherapy and photodynamic therapy in therapeutic bronchoscopy of lung cancers. Eur Respir J. 2006; 28 (1): 200–218. DOI: 10.1183/09031936.06.00014006Mathur PN, Wolf KM, Busk MF, Briete WM, Datzman, M. Fiberoptic bronchoscopic cryotherapy in the management of tracheobronchial obstruction. Chest. 1996; 110: 718–723.Mathur PN, Wolf KM, Busk MF, Briete WM, Datzman, M. Fiberoptic bronchoscopic cryotherapy in the management of tracheobronchial obstruction. Chest. 1996; 110: 718–723.Hetzel M, Babiak AJ, Hetzel J, Merk T, Wibmer T, Lepper PM, Krüger S. Endobronchial tumor debulking with a flexible cryoprobe for immediate treatment of malignant stenosis. J Thorac Cardiovasc Surg. 2010 Apr; 139 (4): 997–1000. DOI: 10.1016/j.jtcvs.2009.06.023Hetzel M, Babiak AJ, Hetzel J, Merk T, Wibmer T, Lepper PM, Krüger S. Endobronchial tumor debulking with a flexible cryoprobe for immediate treatment of malignant stenosis. J Thorac Cardiovasc Surg. 2010 Apr; 139 (4): 997–1000. DOI: 10.1016/j.jtcvs.2009.06.023Hetzel M, Hetzel J, Schumann C, Marx N, Babiak A. Cryorecanalization: a new approach for the immediate management of acute airway obstruction. J Thorac Cardiovasc Surg. 2004; 127 (5): 1427–143. DOI: 10.1016/j.jtcvs.2003.12.032Hetzel M, Hetzel J, Schumann C, Marx N, Babiak A. Cryorecanalization: a new approach for the immediate management of acute airway obstruction. J Thorac Cardiovasc Surg. 2004; 127 (5): 1427–143. DOI: 10.1016/j.jtcvs.2003.12.032Jung JY, Lee SY, Kim DH, et al. Clinical benefits and complications of cryotherapy in advanced lung cancer with central airway obstruction. Tuberc Respir Dis. 2008; 64: 272–277.Jung JY, Lee SY, Kim DH, et al. Clinical benefits and complications of cryotherapy in advanced lung cancer with central airway obstruction. Tuberc Respir Dis. 2008; 64: 272–277.Noppen M, Meysman M, Van Herreweghe R, Lamote J, D’Haese J, Vincken W.Bronchoscopic cryotherapy: preliminary experience. Acta Clin Belg. 2001; 56 (2): 73–77. DOI: 10.1179/acb.2001.013Noppen M, Meysman M, Van Herreweghe R, Lamote J, D’Haese J, Vincken W.Bronchoscopic cryotherapy: preliminary experience. Acta Clin Belg. 2001; 56 (2): 73–77. DOI: 10.1179/acb.2001.013Bertoletti L, Elleuch R, Kaczmarek D, Jean-Francois R, Vergnon JM. Bronchoscopic cryotherapy treatm ent of isolated endolum inal typical carcinoid tum or. Chest. 2006; 130 (5): 1405–1411. DOI: 10.1378/chest.130.5.1405Bertoletti L, Elleuch R, Kaczmarek D, Jean-Francois R, Vergnon JM. Bronchoscopic cryotherapy treatment of isolated endoluminal typical carcinoid tumor. Chest. 2006; 130 (5): 1405–1411. DOI: 10.1378/chest.130.5.1405Maiwand MO, Asimakopoulos G. Cryosurgery for lung cancer: clinical results and technical aspects. Technol Cancer Res Treat. 2004; 3 (2): 143–150. DOI: 10.1177/153303460400300207Maiwand MO, Asimakopoulos G. Cryosurgery for lung cancer: clinical results and technical aspects. Technol Cancer Res Treat. 2004; 3 (2): 143–150. DOI: 10.1177/153303460400300207Lee SH, Choi WJ, Sung SW, Kim YK, Kim CH, Zo JI, Park KJ. Endoscopic cryotherapy of lung and bronchial tumors: a systematic review. Korean J Intern Med. 2011 Jun; 26 (2): 137–44. DOI: 10.3904/kjim.2011.26.2.137Lee SH, Choi WJ, Sung SW, Kim YK, Kim CH, Zo JI, Park KJ. Endoscopic cryo- therapy of lung and bronchial tumors: a systematic review. Korean J Intern Med. 2011 Jun; 26 (2): 137–44. DOI: 10.3904/kjim.2011.26.2.137Johannson KA, Marcoux VS, Ronksley PE, Ryerson CJ. Diagnostic Yield and Complications of Transbronchial Lung Cryobiopsy for Interstitial Lung Disease. A Systematic Review and Metaanalysis.. Ann Am Thorac Soc. 2016 Oct; 13 (10): 1828–1838. DOI: 10.1513/AnnalsATS.201606–461SRJohannson KA, Marcoux VS, Ronksley PE, Ryerson CJ. Diagnostic Yield and Complications of Transbronchial Lung Cryobiopsy for Interstitial Lung Disease. A Systematic Review and Metaanalysis.. Ann Am Thorac Soc. 2016 Oct; 13 (10): 1828–1838. DOI: 10.1513/AnnalsATS.201606–461SRPajares V, Puzo C, Castillo D, Lerma E, Montero MA, Ramos-Barbón D, et al. Diagnostic yield of transbronchial cryobiopsy in interstitial lung disease: a randomized trial. Respirology. 2014 Aug; 19 (6): 900–6. DOI: 10.1111/resp.12322Pajares V, Puzo C, Castillo D, Lerma E, Montero MA, Ramos-Barbón D, et al. Diagnostic yield of transbronchial cryobiopsy in interstitial lung disease: a randomized trial. Respirology. 2014 Aug; 19 (6): 900–6. DOI: 10.1111/resp.12322Poletti V, Casoni GL, Gurioli C, Ryu JH, Tomassetti S. Lung cryobiopsies: a paradigm shift in diagnostic bronchoscopy? Respirology. 2014 Jul; 19 (5): 645–54. Respirology. 2014 Jul;19 (5):645–54. DOI: 10.1111/resp.12309Poletti V, Casoni GL, Gurioli C, Ryu JH, Tomassetti S. Lung cryobiopsies: a paradigm shift in diagnostic bronchoscopy? Respirology. 2014 Jul; 19 (5): 645–54. Respirology. 2014 Jul;19 (5):645–54. DOI: 10.1111/resp.12309Tomic R, Podgaetz E, Andrade RS, Dincer HE. Cryotechnology in diagnosing and treating lung diseases. J Bronchology Interv Pulmonol. 2015 Jan; 22 (1): 76–84. DOI: 10.1097/LBR.0000000000000103Tomic R, Podgaetz E, Andrade RS, Dincer HE. Cryotechnology in diagnosing and treating lung diseases. J Bronchology Interv Pulmonol. 2015 Jan; 22 (1): 76–84. DOI: 10.1097/LBR.0000000000000103Ganganah O, Guo SL, Chiniah M, Li YS. Efficacy and safety of cryobiopsy versus forceps biopsy for interstitial lung diseases and lung tumours: A systematic review and meta-analysis. Respirology. 2016 Jul; 21 (5): 834–41. DOI: 10.1111/resp.12770Ganganah O, Guo SL, Chiniah M, Li YS. Efficacy and safety of cryobiopsy versus forceps biopsy for interstitial lung diseases and lung tumours: A systematic review and meta-analysis. Respirology. 2016 Jul; 21 (5): 834–41. DOI: 10.1111/resp.12770Yilmaz A, Aktaş Z, Alici IO, Cağlar A, Sazak H, Ulus F.Cryorecanalization: keys to success. Surg Endosc. 2012 Oct; 26 (10): 2969–74. DOI: 10.1007/s00464–012–2260–1Yilmaz A, Aktaş Z, Alici IO, Cağlar A, Sazak H, Ulus F.Cryorecanalization: keys to success. Surg Endosc. 2012 Oct; 26 (10): 2969–74. DOI: 10.1007/s00464–012–2260–1Wang H, Zhang N, Li D, Tao M, Zhang J, Zou H, et al. Interventional Bronchoscopies for the Treatment of 112 Cases with Complex Malignant Central Airway Diseases Involved in Bifurcation. Zhongguo Fei Ai Za Zhi. 2016 Dec 20; 19 (12): 854–858. DOI: 10.3779/j.issn.1009–3419.2016.12.08Wang H, Zhang N, Li D, Tao M, Zhang J, Zou H, et al. Interventional Bronchoscopies for the Treatment of 112 Cases with Complex Malignant Central Airway Diseases Involved in Bifurcation. Zhongguo Fei Ai Za Zhi. 2016 Dec 20; 19 (12): 854–858. DOI: 10.3779/j.issn.1009–3419.2016.12.08

The authors declare that there are no conflicts of interest present.