rpmjResearch'n Practical Medicine JournalResearch and Practical Medicine Journal2410-1893"QUASAR", LLC10.17709/2409-2231-2017-4-2-5rpmj-185Research ArticleОбзорыReviewРОЛЬ ЭРИТРОПОЭТИНОВ В ЛЕЧЕНИИ АНЕМИИ У ОНКОЛОГИЧЕСКИХ БОЛЬНЫХTHE ROLE OF ERYTHROPOIETIN IN TREATMENT OF ANEMIA IN CANCER PATIENTShttps://orcid.org/0000-0002-3229-6884БерезинП. Г.BerezinP. G.

Березин Петр Георгиевич, врач-онкоуролог, заведующий консультативно-поликлиническим отделением 

Для корреспонденции: Адрес: 392000, Тамбов, ул. Московская, д. 29В

Petr G. Berezin, oncourologist, Head of Consultative-Polyclinic Department 

For correspondence: Address: 29V Moskovskaya St., Tambov, 392000

tambov-onco@bk.ruhttps://orcid.org/0000-0002-0123-5202МиловановВ. В.MilovanovV. V.

Милованов Владимир Васильевич, главный врач

Vladimir V. Milovanov, Chief Physician

https://orcid.org/0000-0003-4580-1250ИванниковА. А.IvannikovA. A.

Иванников Андрей Андреевич, заместитель главного врача по медицинской части

Andrey A. Ivannikov, Deputy chief doctor on medical division

ГБУЗ «Тамбовский областной онкологический клинический диспансер»РоссияTambov Regional Oncology Clinical DispensaryRussian Federation201717062017423742Copyright © Березин П.Г., Милованов В.В., Иванников А.А., 20172017Березин П.Г., Милованов В.В., Иванников А.А.Berezin P.G., Milovanov V.V., Ivannikov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpmj.ru/rpmj/article/view/185

Злокачественные новообразования — серьезное патологическое состояние как с точки зрения течения заболевания и необходимости проведения лечения, так и прогноза для жизни пациентов. Ухудшение качества жизни, социальная дезадаптация (снижение физической активности, смена места работы, повышение утомляемости и т. д.) являются осложнениями течения заболевания, вызванными развитием анемии, требующей жизненной необходимости ее коррекции.В данной статье проведен анализ исследований эффективности рекомбинантного эритропоэтина — Эпоэтинтета в лечении пациентов с NON-миелоидными опухолями и хронической почечной недостаточностью (ХПН) у онкологических больных. Продемонстрированы высокая эффективность и безопасность терапии препарата у данной категории пациентов. Даны рекомендации по оптимальной дозе препарата с целью получения наиболее выраженного клинического эффекта лечения, увеличение лечебной дозы препарата при недостаточном росте уровня гемоглобина на 100% и более позволяет осуществлять индивидуальный подход к коррекции анемии. Определена возможность применения его в рутинной клинической практике врача-онколога, а именно в амбулаторно-поликлинических условиях.

Malignant neoplasms are a serious pathological condition, both in terms of the course of the disease and the need for treatment, and a prognosis for the life of patients. The deterioration in the quality of life, social disadaptation (reduced physical activity, job change, fatigue, etc.) is a complication of the course of the disease caused by the development of anemia, which requires a vital need for its correction. This article analyzes the efficacy of recombinant erythropoietin — Epoetin-theta in the treatment of patients with NON — myeloid tumors and CRF (chronic renal failure) in cancer patients. The high efficacy and safety of drug therapy in this category of patients are demonstrated. Recommendations are given on the optimal dose of the drug in order to obtain the most pronounced clinical effect of treatment, increasing the therapeutic dose of the drug with an insufficient increase in the hemoglobin level by 100% or more allows an individual approach to the correction of anemia. The possibility of its application in routine clinical practice of the oncologist’s doctor, namely in out-patientpolyclinic conditions, has been determined.

Эпоэтин-тетаанемияNON-миелоидные опухолиХПНэффективностькачество жизниEpoetin-thetaanemiaNON-myeloid tumorschronic renal failure (CRF)efficacyquality of lifeReferencesKrantz SB. Erythropoietin. Blood. 1991; 77 (3): 419–434.Krantz SB. Erythropoietin. Blood. 1991; 77 (3): 419–434.Nowrousian MR, et al. Pathophysiology of Cancer-related anemia. In Smythe J. et al. (eds). Rh-erythropoietin in Cancer Supportive Treatment. New-York: Marcel Dekker, 1966, p.13–34.Nowrousian MR, et al. Pathophysiology of Cancer-related anemia. In Smythe J. et al. (eds). Rh-erythropoietin in Cancer Supportive Treatment. New-York: Marcel Dekker, 1966, p.13–34.Means RT Jr. Pathogenesis of the anemia of chronic disease: a cytokine — mediated anemia. Cytokines Cell Mol Ther. 1995; 13 (3): 32–37..Means RT Jr. Pathogenesis of the anemia of chronic disease: a cytokine — mediated anemia. Cytokines Cell Mol Ther. 1995; 13 (3): 32–37.Salvarani C, Casali B, Salvo D, Brunati C, Macchioni PL, Massai G, et al. The role of interleukine-1 erythropoietin and red cell bound immunoglobulins in the anem ia of rheumatoid arthritis. CEIN Exprheumatol. 2000; 9: 241–246.Salvarani C, Casali B, Salvo D, Brunati C, Macchioni PL, Massai G, et al. The role of interleuk ine-1 erythropoietin and red cell bound im m unoglobulins in the anem ia of rheumatoid arthritis. CEIN Exprheumatol. 2000; 9: 241–246 .Canaparo R, Casale F, Muntoni E, Zara GP, Della Pepa C, Berno E, et al. Plasma erythropoietin concentrations in patients receiving intensive platinum or nonplatinum chemotherapy. Br J ClinPharmacol. 2000; 50 (2): 146–153.Canaparo R, Casale F, Muntoni E, Zara GP, Della Pepa C, Berno E, et al. Plasma erythropoietin concentrations in patients receiving intensive platinum or nonplatinum chemotherapy. Br J ClinPharmacol. 2000; 50 (2): 146–153 .Pivot X, Guardiola E, Etienne M, Thyss A, Foa C, Otto J, et al. An analysis of potential factors allowing an individual prediction of cisplatin-induced anemia. Eur J Cancer 2000; 36 (7): 852–857. DOI: 10.1016/S0959–8049 (00)00010–1Pivot X, Guardiola E, Etienne M, Thyss A, Foa C, Otto J, et al. An analysis of potential factors allowing an individual prediction of cisplatin-induced anemia. Eur J Cancer 2000; 36 (7): 852–85. DOI: 10.1016/S0959–8049(00)00010–17.Wood PA, Hrushesky WJ. Cisplatin — associated anemia: An erythropoietin deficiency syndrome. J Clin Invest. 1995; 95 (4): 1650–1659. DOI: 10.1172/JCI117840Wood PA, Hrushesky WJ. Cisplatin — associated anemia: An erythropoietin deficiency syndrome. J Clin Invest. 1995; 95 (4): 1650–1659. DOI: 10.1172/JCI117840Coiffiet B. Anemia associated with non- platinum chemotherapy (CT) for Hodgkins lymphoma (NHL). Eur J Cancer. 1999; 35 (Suppl 4): S331 (abstr).Coiffiet B. Anemia associated with non- platinum chemotherapy (CT) for Hodgkins lymphoma (NHL). Eur J Cancer. 1999; 35 (Suppl 4): S331 (abstr).Groopman JE, Itri LM. Chemotherapy-induced anemia in adults: incidenceand treatment. J Nate Cancer Inst. 1999; 91 (19): 1616–1634.Groopman JE, Itri LM. Chemotherapy-induced anemia in adults: incidenceand treatment. J Nate Cancer Inst. 1999; 91 (19): 1616–1634.Macdougall IC. Novel erythropoiesis-stimulating agents: a new era in anemia management. Clin J Am Soc Nephrol. 2008 Jan; 3 (1): 200–2007. DOI: 10.2215/CJN.03840907Macdougall IC. Novel erythropoiesis-stimulating agents: a new era in anemia management. Clin J Am Soc Nephrol. 2008 Jan; 3 (1): 200–2007. DOI: 10.2215/CJN.03840907Бабичева ЛГ, Поддубная ИВ. Лечение анемии в онкологии: роль нового стимулятора эритропоэза Аранесп (дарбэпоэтин альфа). Современная онкология. 2007; 9 (3): 69–74.Babicheva LG, Poddubnaya IV. Lechenie anemii v onkologii: rol’ novogo stimulyatora eritropoeza Aranesp (darbepoetin al’fa). Journal of Modern Oncology. 2007; 9 (3): 69–74.(In Russian).Beer TM, Tangen CM, Bland LB, Thompson IM, Crawford ED. Prognostic value of anemia in newly diagnosed metastatic prostate cancer: a multivariate analysis of southwest oncology group study 8894. J Urol. 2004 Dec;172 (6 Pt 1):2213–7.Beer TM, Tangen CM, Bland LB, Thompson IM, Crawford ED. Prognostic value of anemia in newly diagnosed metastatic prostate cancer: a multivariate analysis of southwest oncology group study 8894.J Urol. 2004 Dec;172 (6 Pt 1):2213–7.Ludwig H, Birgegard G, Barret-Lee P, et al. Prevalence and management of anemia in patients with hematologic maligmancies and solid tumors: results from the European Cancer anemia Survey (ECAS). Blood 2002 abstr 884.Ludwig H, Birgegard G, Barret-Lee P, et al. Prevalence and management of anemia in patients with hematologic maligmancies and solid tumors: results from the European Cancer anemia Survey (ECAS). Blood 2002 abstr 884.Skillings JR, Rogers-Melamed I, Nabholtz JM, Sawka C, Gwadry-Sridhar F, Moquin JP, et al. An epidemiological review of red cell transfusions in Cancer chemotherapy. Cancer Prev Control. 1999 Jun; 3 (3): 207–212.Skillings JR, Rogers-Melamed I, Nabholtz JM, Sawka C, Gwadry-Sridhar F, Moquin JP, et al. An epidemiological review of red cell transfusions in Cancer chemotherapy. Cancer Prev Control. 1999 Jun; 3 (3): 207–212 .Barrett-Lee PJ, Bailey NP, O’Brien ME, Wager E. Large-scale UK audit of blood transfusion reguirements and anemia in patients receiving cytotoxic chemotherapy. Br J Cancer. 2000 Jan; 82 (1): 93–97. DOI: 10.1054/bjoc.1999.0883Barrett-Lee PJ, Bailey NP, O’Brien ME, Wager E. Large-scale UK audit of blood transfusion reguirements and anemia in patients receiving cytotoxic chemotherapy. Br J Cancer. 2000 Jan; 82 (1): 93–97. DOI: 10.1054/bjoc.1999.0883Mohammed A, Bagalagel A, MacDonald K, Abraham I. Clinical efficacy and safety of XM01, a biosimilar recombinant human erythropoietin, in the management of anemia. Biosimilars. 2013; 3: 45–53. DOI: 10.2147/BS.S28709.Mohammed A, Bagalagel A, MacDonald K, Abraham I. Clinical efficacy and safety of XM01, a biosimilar recombinant human erythropoietin, in the management of anemia. Biosimilars. 2013; 3: 45–53. DOI: 10.2147/BS.S28709Tjulandin SA, Bias P, Elsässer R, Gertz B, Kohler E, Buchner A. Epoetin Theta with a New Dosing Schedule in Anaemic Cancer Patients Receiving Nonplatinum-Based Chemotherapy: A Randomised Controlled Trial. Arch Drug Inf. 2011 Sep; 4 (3): 33–41. DOI: 10.1111/j.1753–5174.2011.00035.xTjulandin SA, Bias P, Elsässer R, Gertz B, Kohler E, Buchner A. Epoetin Theta with a New Dosing Schedule in Anaemic Cancer Patients Receiving Nonplatinum-Based Chemotherapy: A Randomised Controlled Trial. Arch Drug Inf. 2011 Sep; 4 (3): 33–41. DOI: 10.1111/j.1753–5174.2011.00035.x

The authors declare that there are no conflicts of interest present.