rpmjResearch'n Practical Medicine JournalResearch and Practical Medicine Journal2410-1893"QUASAR", LLC10.17709/2409-2231-2014-1-1-69-73rpmj-20Research ArticleОбзорыReviewГОРМОНАЛЬНАЯ ТЕРАПИЯ С ИСПОЛЬЗОВАНИЕМ АГОНИСТОВ И АНТАГОНИСТОВ ЛЮТЕИНИЗИ- РУЮЩЕГО ГОРМОНА РЕЛИЗИНГ ГОРМОНА У БОЛЬНЫХ РАКОМ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫHORMONE THERAPY WITH USAGE OF AGONISTS AND ANTAGONISTS OF LUTEINIZING HORMONE RELEASING HORMONE IN PATIENTS WITH PROSTATE CANCERНюшкоК. М.NyushkoK. M.

к. м.н., старший научный сотрудник отделения онкоурологии МНИОИ им. П. А. Герцена – филиал ФГБУ «ФМИЦ им. П. А. Герцена» Минздрава России Адрес: 125284, Москва, 2‑й Боткинский проезд, д. 3. Телефон: +7 (495) 945‑15‑72

PhD, senior researcher of oncourological department of Moscow Oncology Institute of the Hertsen FMRC MH RF 3, 2 Botkinskiy proezd, 125284, Russian Federation, Moscow Теl: +7 (495) 945‑15‑72

kirandja@yandex.ruКрашенинниковА. А.KrasheninnikovA. A.

кандидат медицинских наук, научный сотрудник отделения онкоурологии МНИОИ им. П.А. Герцена – филиал ФГБУ «ФМИЦ им. П.А. Герцена» Минздрава России

PhD, researcher of oncourological department of P.A. Herzen Moscow Research Oncological Institute of the P.A. Herzen Federal Medical Research Center of Ministry of Health of Russian Federation

ГоловащенкоМ. П.GolovaschenkoM. P.

младший научный сотрудник отделения онкоурологии МНИОИ им. П.А. Герцена – филиал ФГБУ «ФМИЦ им. П.А. Герцена» Минздрава России

junior researcher of oncourological department of P.A. Herzen Moscow Research Oncological Institute of the P.A. Herzen Federal Medical Research Center of Ministry of Health of Russian Federation

КапринА. Д.KaprinA. D.

доктор медицинских наук, профессор, чл.-корр. РАН, генеральный директор ФГБУ «ФМИЦ им. П.А. Герцена» Минздрава России

MD, professor, corresponding member of RAS, general director of the P.A. Herzen Federal Medical Research Center of Ministry of Health of Russian Federation

МНИОИ им. П.А.Герцена — филиал ФГБУ «ФМИЦ им. П.А.Герце на» Минздрава России (Москва, Российская Федерация), 125284, Российская Федерация, Москва, 2-ой Боткинский проезд, дом 3РоссияMoscow Oncology Institute of the Hertsen FMRC MH RF (Moscow, Russian Federation) 3, 2 B otkinskiy proezd, 125284, Russian Federation, MoscowRussian FederationФГБУ «ФМИЦ им. П.А.Герце на» Минздрава России (Обнинск, Российская Федерация) 249036, Российская Федерация, Калужская область, г. Обнинск, ул. Королёва, д. 4РоссияHertsen FMRC MH RF (Obninsk, Russian Federation) 4, st. Korolev, 249036, Russian Federation, Kaluga region, ObninskRussian Federation201416012015116973Copyright © Нюшко К.М., Крашенинников А.А., Головащенко М.П., Каприн А.Д., 20152015Нюшко К.М., Крашенинников А.А., Головащенко М.П., Каприн А.Д.Nyushko K.M., Krasheninnikov A.A., Golovaschenko M.P., Kaprin A.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpmj.ru/rpmj/article/view/20

Рак предстательной железы (РПЖ) является одной из наиболее актуальных проблем современной онкоурологии. Гормональная терапия (ГТ) с использованием медикаментозной кастрации является основным методом лечения больных метастатическим РПЖ. ГТ с использованием нового класса препаратов, блокирующих рецепторы лютеинизирующего гормона релизинг гормона (ЛГРГ), является перспективным и эффективным методом кастрационной терапии, обладающим рядом существенных преимуществ по сравнению с использованием аналогов ЛГРГ. В статье представлен обзор результатов исследований, сравнивших эффективность и побочные эффекты ГТ с использованием антагонистов и аналогов ЛГРГ.

Prostate cancer (PC) is one of the most actual problems of modern oncourology. Hormone therapy (HT) using medical castration is the main method of treatment of patients with metastatic PC. HT with usage of the new class of drugs that block the receptors for luteinizing hormone releasing hormone (LHRH) is a promising and effective method of castration therapy that has a number of significant advantages over the use of analogues LHRH. This article presents areview of studies that compared the effectiveness and side effects of HT using antagonists and analogues LHRH.

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The authors declare that there are no conflicts of interest present.