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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rpmj</journal-id><journal-title-group><journal-title xml:lang="ru">Research'n Practical Medicine Journal</journal-title><trans-title-group xml:lang="en"><trans-title>Research and Practical Medicine Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2410-1893</issn><publisher><publisher-name>"QUASAR", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17709/2409-2231-2017-4-4-10</article-id><article-id custom-type="elpub" pub-id-type="custom">rpmj-224</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Review</subject></subj-group></article-categories><title-group><article-title>АКТУАЛЬНЫЕ ВОПРОСЫ ДИАГНОСТИКИ И ЛЕЧЕНИЯ БЕСПЛОДИЯ   У ЖЕНЩИН   С ВНУТРЕННИМ  ГЕНИТАЛЬНЫМ ЭНДОМЕТРИОЗОМ</article-title><trans-title-group xml:lang="en"><trans-title>TOPICAL ISSUES  OF DIAGNOSIS  AND TREATMENT OF INFERTILITY IN WOMEN  WITH INTERNAL GENITAL ENDOMETRIOSIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4977-1183</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Меджидова</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Medzhidova</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Меджидова  Айшат Меджидовна - аспирант кафедры акушерства и гинекологии педиатрического, стоматологического и медико-профилактического факультетов.</p><p>367000, Республика Дагестан, Махачкала, пл. Ленина, д. 1</p></bio><bio xml:lang="en"><p>Aishat M. Medzhidova - post-graduate  student of obstetrics and gynecology department of pediatric, dental and medical-prophylactic faculties.</p><p>1 Lenina Sq., Makhachkala, Respublika Dagestan 367000</p></bio><email xlink:type="simple">asholya2012@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эседова</surname><given-names>А. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Esedova</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эседова Асият Эседовна – доктор медицинских наук, профессор, заведующая  кафедрой акушерства и гинекологии педиатрического, стоматологического и медико-профилактического факультетов.</p><p>367000, Республика Дагестан, Махачкала, пл. Ленина, д. 1</p></bio><bio xml:lang="en"><p>Asiyat E. Esedova - MD, professor, head of obstetrics and gynecology department of pediatric, dental and medical-prophylactic faculties.</p><p>1 Lenina Sq., Makhachkala, Respublika Dagestan 367000</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Дагестанский государственный медицинский университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Dagestan State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>13</day><month>12</month><year>2017</year></pub-date><volume>4</volume><issue>4</issue><fpage>89</fpage><lpage>98</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Меджидова А.М., Эседова А.Э., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Меджидова А.М., Эседова А.Э.</copyright-holder><copyright-holder xml:lang="en">Medzhidova A.M., Esedova A.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpmj.ru/rpmj/article/view/224">https://www.rpmj.ru/rpmj/article/view/224</self-uri><abstract><p>Проблема бесплодия у женщин с внутренним генитальным эндометриозом является одной из основных среди встречающихся причин указанной проблемы бесплодия. В обзоре представлены современные литературные данные последних лет, в которых эндометриоз рассматривается как одна из основных причин бесплодия. Несмотря на существующие методы диагностики и лечения бесплодия, ассоциированного с эндометриозом, на сегодняшний день нет единого алгоритма ведения такой категории больных. Необходимость определения тактики обследования является важным компонентом в эффективности лечения. При выработке плана ведения пациенток с бесплодием, ассоциированным с эндометриозом, следует учитывать возраст женщины, продолжительность бесплодия, наличие боли и стадию заболевания. Лечение бесплодия, связанного с эндометриозом, включает хирургические методы, гормональное лечение и использование вспомогательных репродуктивных технологий (ВРТ).</p><p>По мнению ряда авторов, развитие аденомиоза происходит во время менструации на фоне процессов регенерации, заживления и реэпителизации слизистой оболочки матки. В этот момент может произойти внедрение клеток эндометрия в «ослабленную» переходную зону, имеющую структурные и функциональные различия по сравнению с остальным миометрием. «Переходная зона» JZ — это область во внутреннем слое миометрия, получившая множество определений: промежуточная зона, архимиометрий, внутренний миометрий, субэндометриальный миометрий. Эта зона представляет собой базальный слой миометрия и состоит из продольно расположенных гладкомышечных волокон, обычно толщина ее у женщин репродуктивного возраста не превышает 2–8 мм. Многие исследователи считают ключевым патогенетическим звеном аденомиоза механическое повреждение переходной зоны. Основным методом скрининга и золотым стандартом первичной инструментальной диагностики в гинекологии остается трансвагинальное ультразвуковое исследование (УЗИ) органов малого таза. Также может быть использована магнитно-резонансная томография (МРТ), преимуществами которой по сравнению с УЗИ являются возможность получения изображения в любой плоскости и отсутствие «невидимых» зон, высокая разрешающая способность. Систематический обзор и мета-анализ данных, полученных с помощью трансвагинального УЗИ и МРТ у женщин с гистологически подтвержденным аденомиозом, показали сходный высокий уровень точности постановки диагноза, однако важным преимуществом МРТ была стандартизация изображений. Однако не всегда при выявленных с помощью МРТ отклонениях переходной зоны матки в последующем диагностируется гистологически подтвержденный аденомиоз. Назрела существенная необходимость в выработке единой терминологии и классификации нарушений переходной зоны миометрия, а также систематизации представлений об инструментальных критериях диагностики аденомиоза.</p></abstract><trans-abstract xml:lang="en"><p>The problem of infertility in women with internal genital endometriosis is one of the main reasons among the reasons for this infertility problem. The review presents modern literature data of recent years, in which endometriosis is considered as one of the main causes of infertility. Despite the existing methods of diagnosis and treatment of infertility associated with endometriosis, today there is no single algorithm for conducting such a category of patients. The need to define survey tactics is an important component in the effectiveness of treatment. When developing a plan for managing patients with infertility associated with endometriosis, the age of the woman, duration of infertility, the presence of pain and the stage of the disease should be taken into account. Treatment of infertility associated with endometriosis includes surgical methods, hormone treatment and the use of ART.</p><p>According to some authors, the development of adenomyosis occurs during menstruation against the backdrop of regeneration, healing and re-epithelialization of the uterine mucosa. At this point, the introduction of endometrial cells into the “weakened” transition zone, which has structural and functional differences compared to the rest of the myometrium, can occur. The JZ “transition zone” is the region in the inner layer of the myometrium, which has received many definitions: an intermediate zone, an archiometry, an internal myometrium, a subendometric myometrium. This zone is a basal layer of myometrium and consists of longitudinally placed smooth muscle fibers, usually its thickness in women of reproductive age does not exceed 2–8 mm. Many researchers consider mechanical damage to the transition zone as the key pathogenetic link in adenomyosis. The main method of screening and the “gold standard” of primary instrumental diagnostics in gynecology remains transvaginal ultrasound examination of pelvic organs. Magnetic resonance imaging can also be used, the advantage of which in comparison with ultrasound is the possibility of obtaining an image in any plane and the absence of “invisible” zones, has a high resolution. A systematic review and meta-analysis of data obtained with transvaginal ultrasound and MRI in women with histologically confirmed adenomyosis showed a similarly high level of accuracy of diagnosis, but an important advantage of MRI was the standardization of images. However, not always with the deviations of the transitional zone of the uterus revealed with the help of MRI, histologically confirmed adenomyosis is subsequently diagnosed. There is a significant need to develop a common terminology and classification of violations of the transition zone of the myometrium, as well as systematization of ideas about instrumental criteria for diagnosis of adenomyosis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>эндометриоз</kwd><kwd>бесплодие</kwd><kwd>лечение бесплодия</kwd><kwd>диагностика эндометриоза</kwd><kwd>диеногест</kwd><kwd>магнитно-резонансная томография</kwd><kwd>«переходная зона» JZ</kwd><kwd>ВРТ</kwd><kwd>ЭКО</kwd></kwd-group><kwd-group xml:lang="en"><kwd>endometriosis</kwd><kwd>infertility</kwd><kwd>infertility treatment</kwd><kwd>endometriosis diagnosis</kwd><kwd>dienogest</kwd><kwd>magnetic resonance imaging</kwd><kwd>"transition zone"  JZ</kwd><kwd>ART</kwd><kwd>IVF</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кулаков В. И., Леонов Б. В., Кузьмичев Л. Н. Лечение женского и мужского бесплодия. М., 2005, 592 с.</mixed-citation><mixed-citation xml:lang="en">Kulakov VI, Leonov BV, Kuz’michev LN. Lechenie zhenskogo i muzhskogo besplodiya [Treatment of female and male infertility]. Мoscow, 2005, 592 p. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Исамухамедова М. А., Шамсиева Л. Э. Возможности ультразвукового мониторинга и определение гормонального профиля в диагностике женского бесплодия эндокринного характера. Медицинская визуализация. 2013; 1: 70–79.</mixed-citation><mixed-citation xml:lang="en">Isamukhamedova MA, Shamsieva LE. Possibilities pf Ultrasonic Monitoring and Definition of the Hormonal Profile in Diagnostics of Female Infertility of Endocrine Character. Medical Visualization. 2013; 1: 70–79. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Эндометриоз: диагностика, лечение и реабилитация. Клинические рекомендации по ведению больных. Под редакцией Л. В. Адамян. М., 2013, 86 с.</mixed-citation><mixed-citation xml:lang="en">Endometrioz: diagnostika, lechenie i reabilitatsiya. Klinicheskie rekomendatsii po  vedeniyu bol’nykh [Endometriosis: diagnosis, treatment and rehabilitation. Clinical recommendations for managing patients]. Ed by Adamyan LV. Moscow, 2013, 86 p. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Коробков Д. М. Трубно-перитонеальное бесплодие у женщин репродуктивного возраста и его клинико-факторный анализ. Бюллетень науки и практики. 2016; 12 (13): 186–189. DOI: 10.5281/zenodo.205194</mixed-citation><mixed-citation xml:lang="en">Korobkov Denis. Tuboperitoneal infertility in women of reproductive age and his clinic-factor analysis. Bulletin of Science and Practice. 2016; 12 (13): 186–189. DOI: 10.5281/zenodo.205194 (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Гаспаров А. С. Трубно-перитонеальное бесплодие у женщин. Проблемы репродукции. 2009; 5: 43.</mixed-citation><mixed-citation xml:lang="en">Gasparov AS. Trubno-peritoneal’noe besplodie u zhenshchin. Problemy reproduktsii (Russian Journal of Human Reproduction). 2009; 5: 43. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Шуляк И. Ю. Фолликулогенез при различных формах эндометриоза. Автореф. … к. м.н. М., 2009, 24 с.</mixed-citation><mixed-citation xml:lang="en">Shulyak IYu. Follikulogenez pri razlichnykh formakh endometrioza [Folliculogenesis in various forms of endometriosis]. Diss. Мoscow, 2009, 24 p. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Carvalho L, Podgaec S, Bellodi-Privato M, Falcone T, Abrao MS. Role of eutopic endometrium in pelvic endometriosis. J Minim Invasive Gynecol. 2011 Jul-Aug; 18 (4): 419–27. DOI: 10.1016/j.jmig.2011.03.009</mixed-citation><mixed-citation xml:lang="en">Carvalho L, Podgaec S, Bellodi-Privato M, Falcone T, Abrao MS. Role  of  eutopic  endometrium  in  pelvic  endometriosis.  J Minim  Invasive  Gynecol.  2011  Jul-Aug;  18  (4):  419–27.  DOI: 10.1016/j.jmig.2011.03.009</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Коган Е. А., Акопова Е. О., Унанян А. Л. Бесплодие при эндометриозе: краткий очерк современных представлений. Пространство и время. 2017; 1 (27): 251–259.</mixed-citation><mixed-citation xml:lang="en">Kogan EA, Akopova EO, Unanyan AL. Infertility in Endometrio sis: A Brief Sketch of Modern Concepts. Space and Time. 2017; 1 (27): 251–259. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Девятова Е. А., Цатурова К. А., Вартанян Э. В. Оценка вероятности успеха импоантации при экстракорпоральном оплодотворении. Dоктор.Ру. Гинекология. Эндокринология. 2016; 7 (124): 34–38.</mixed-citation><mixed-citation xml:lang="en">Devyatova EA, Tsaturova KA, Vartanyan EV. Assessing Chances of Successful Implantation in In-Vitro-Fertilization. Doctor.Ru. 2016; 7 (124): 34–38. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Altmäe S, Esteban FJ, Stavreus-Evers A, Simón C, Giudice L, Lessey BA, et al. Guidelines for the design, analysis and interpretation of ‘omics’ data: focus on human endometrium. Hum Reprod Update. 2014 Jan-Feb;20 (1):12–28. DOI: 10.1093/humupd/dmt048</mixed-citation><mixed-citation xml:lang="en">Altmäe S, Esteban FJ, Stavreus-Evers A, Simón C, Giudice L, Lessey BA, et al. Guidelines for the design, analysis and interpretation of ‘omics’ data: focus on human endometrium. Hum Reprod Update. 2014 Jan-Feb;20 (1):12–28. DOI: 10.1093/humupd/dmt048</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Uysal S, Özbay EP, Ekinci T, Aksüt H, Karasu S, Işık AZ, Soylu F. Endometrial spiral artery Doppler parameters in unexplained infertility patients: is endometrial perfusion an important factor in the etiopathogenesis? J Turk Ger Gynecol Assoc. 2012 Sep 1;13 (3):169–71. DOI: 10.5152/jtgga.2012.22</mixed-citation><mixed-citation xml:lang="en">Uysal S, Özbay EP, Ekinci T, Aksüt H, Karasu S, Işık AZ, Soylu F. Endometrial  spiral  artery  Doppler  parameters  in  unexplained infertility patients: is endometrial perfusion an important factor in the etiopathogenesis? J Turk Ger Gynecol Assoc. 2012 Sep 1;13 (3):169–71. DOI: 10.5152/jtgga.2012.22</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Адамян Л. В., Сухих Г. Т. Состояние и перспективы репродуктивного здоровья населения России. Современные технологии в диагностике и лечении гинекологических заболеваний. М.: Медицина, 2007, с. 5–19.</mixed-citation><mixed-citation xml:lang="en">Adamyan LV, Sukhikh GT. Sostoyanie i perspektivy reproduktivnogo zdorov’ya naseleniya Rossii. Sovremennye tekhnologii v diagnostike i lechenii ginekologicheskikh zabolevanii [Status and prospects of reproductive health in Russia. Modern technologies in the diagnosis and treatment of gynecological diseases]. Мoscow: «Meditsina» Publ., 2007, pp. 5–19. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Баскаков В. П. Клиника и лечение эндометриоза. Л.-Медицина, Ленинградское отделение, 1990.</mixed-citation><mixed-citation xml:lang="en">Baskakov  VP. Klinika  i  lechenie  endometrioza  [Clinic  and treatment of endometriosis]. L.-Meditsina, 1990. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Tokushige N, Markham R, Russell P, Fraser IS. High density of small nerve fibres in functional layer of the endometrium in women with endometriosis. Hum Reprod. 2006 Mar;21 (3):782– 7. DOI: 10.1093/humrep/dei368</mixed-citation><mixed-citation xml:lang="en">Tokushige N, Markham R, Russell P, Fraser IS. High density of small nerve fibres in functional layer of the endometrium in women with endometriosis. Hum Reprod. 2006 Mar;21 (3):782–7. DOI: 10.1093/humrep/dei368</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Адамян Л. В., Гаспарян С. А. Генитальный эндометриоз. Современный взгляд на проблему. Ставрополь: СГМА, 2002, 228 с.</mixed-citation><mixed-citation xml:lang="en">Adamyan L. V.,     Gasparyan S. A. Genital’nyi     endometrioz. Sovremennyi vzglyad na problem [Genital endometriosis]. Stavropol’, 2002, 228 p. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Сочетанные доброкачественные опухоли и гиперпластические процессы матки (миома, аденомиоз, гиперплазия эндометрия). Под ред. Л. В. Адамян. М., 2015, 92 с.</mixed-citation><mixed-citation xml:lang="en">Sochetannye dobrokachestvennye opukholi i giperplasticheskie protsessy matki (mioma, adenomioz, giperplaziya endometriya) [Combined benign tumors and hyperplastic processes of the uterus (myoma, adenomyosis, endometrial hyperplasia)]. Ed by Adamyan LV. Мoscow, 2015, 92 p. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Адамян Л. В., Андреева Е. Н. Роль современной гормонмодулирующей терапии в комплексном лечении генитального эндометриоза. Проблемы репродукции. 2011; 6: 66–77.</mixed-citation><mixed-citation xml:lang="en">Adamian LV, Andreeva EN. The role of hormone modulating therapy in the treatment of genital endometriosis. Problemy reproduktsii (Russian Journal of Human Reproduction). 2011; 6: 66–77. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Баскаков В. П. и соавт. Эндометриоидная болезнь. СПб., 2002, 460 с.</mixed-citation><mixed-citation xml:lang="en">Baskakov VP, et al. Endometrioidnaya bolezn’ [Endometriosis disease]. St.Petersburg, 2002, 460 p. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Гаврилова Т. Ю. Аденомиоз: патогенез, диагностика, лечение, методы реабилитации. Автореф. … д. м.н. М., 2007, 44 с.</mixed-citation><mixed-citation xml:lang="en">Gavrilova  TYu.  Adenomioz:  patogenez,  diagnostika,  lechenie, metody reabilitatsii [Adenomyosis: pathogenesis, diagnosis, treatment, rehabilitation methods]. Diss. Мoscow, 2007, 44 p. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Бурлев В. А., Ильясова Н. А., Гаврилова Т. Ю., Адамян Л. В. Дополнительные критерии оценки стадий распространения аденомиоза. Проблемы репродукции. 2006; 12 (3): 47–52.</mixed-citation><mixed-citation xml:lang="en">Burlev VA, Il’yasova NA, Gavrilova TYu, Adamyan LV. Dopolnitel’nye kriterii otsenki stadii rasprostraneniya adenomioza. Problemy reproduktsii (Russian Journal of Human Reproduction). 2006; 12 (3): 47–52. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Унанян А. Л., Сидорова И. С., Коган Е. А., Демура Т. А., Демура С. А. Активный и неактивный аденомиоз: вопросы патогенеза и патогенетической терапии. Акушерство и гинекология. 2013; 4: 10–13.</mixed-citation><mixed-citation xml:lang="en">Unanyan  AL,  Sidorova  IS,  Kogan  EA,  Demura  TA,  Demura SA. Active and inactive adenomyosis: problems in the pathogenesis and pathogenetic therapy. Obstetrics and Gynecology. 2013; 4: 10–13. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Унанян А. Л., Аракелов С. Э., Гуриев Т. Д. Аденомиоз и комбинированная гормональная контрацепция: непростые отношения. Dоктор.Ру. Гинекология. 2015; 11 (112): 29–32.</mixed-citation><mixed-citation xml:lang="en">Unanyan AL, Arakelov SE, Guriyev TD. Complicated Relationship Between Adenomyosis and Combined Hormonal Contraception. Doctor.Ru. 2015; 11 (112): 29–32. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Brosens JJ, Barker FG, de Souza NM. Myometrial zonal differentiation and uterine junctional zone hyperplasia in the non-pregnant uterus. Hum Reprod Update. 1998 Sep-Oct;4 (5):496–502.</mixed-citation><mixed-citation xml:lang="en">Brosens JJ, Barker FG, de Souza NM. Myometrial zonal differentiation and uterine junctional zone hyperplasia in the non-pregnant uterus. Hum Reprod Update. 1998 Sep-Oct;4 (5):496–502.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Оразов М. Р. Возможности метода магнитно-резонанской томографии в диагностике аденомиоза с тазовым болевым синдромом. Московский хирургический журнал. 2014; 4 (38): 25–28.</mixed-citation><mixed-citation xml:lang="en">Orazov  MR. Possibilities of  the  method  of  magnetic-resonance tomography  in  diagnostics of adenomyosis with pelvic pain syndrome. Moscow Surgical Journal. 2014; 4 (38): 25–28. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Тапильская Н. И., Гайдуков С. Н., Шанина Т. Б. Аденомиоз как самостоятельный фенотип дисфункции эндометрия. Эффективная фармакотерапия. 2015; 5: 62–68.</mixed-citation><mixed-citation xml:lang="en">Tapilskaya NI, Gaydukov SN, Shanina TB. Adenomyosis as a Separate Phenotype of Endometrial Dysfunction. Effective Pharmacotherapy. 2015; 5: 62–68. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Kunz G, Beil D, Huppert P, Noe M, Kissler S, Leyendecker G. Adenomyosis in endometriosis prevalence and impact on fertility. Evidence from magnetic resonance imaging. Hum Reprod. 2005 Aug;20 (8):2309–16. DOI: 10.1093/humrep/dei021</mixed-citation><mixed-citation xml:lang="en">Kunz  G,  Beil  D,  Huppert  P,  Noe  M,  Kissler  S,  Leyendecker G. Adenomyosis in endometriosis prevalence and impact on fertility. Evidence from magnetic resonance imaging. Hum Reprod. 2005 Aug;20 (8):2309–16. DOI: 10.1093/humrep/dei021</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Parazzini F, Mais V, Cipriani S, Busacca M, Venturini P; GISE. Determinants of adenomyosis in women who underwent hysterectomy for benign gynecological conditions: Resulys from a prospective multicentric study in Italy. Eur J Obstet Gynecol Reprod Biol. 2009 Apr;143 (2):103–6. DOI: 10.1016/j.ejogrb.2008.12.010.</mixed-citation><mixed-citation xml:lang="en">Parazzini F, Mais V, Cipriani S, Busacca M, Venturini P; GISE. Determinants of adenomyosis in women who underwent hysterectomy for benign gynecological conditions: Resulys from a prospective multicentric study in Italy. Eur J Obstet Gynecol Reprod Biol. 2009 Apr;143 (2):103–6. DOI: 10.1016/j.ejogrb.2008.12.010.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Зотова О. А., Артымук Н. В. Аденомиоз: Клиника, факторы риска, проблемы диагностики и лечения. Consilium Medicum. Гинекология. 2013; 15 (6): 31–34.</mixed-citation><mixed-citation xml:lang="en">Zotova OA, Artymuk NV. Adenomyosis: clinic, risk factors and problems of diagnosis and treatment. Consilium Medicum. 2013; 15 (6): 31–34. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Maubon A, Faury A, Kapella M, Pouquet M, Piver P. Uterine junctional zone at magnetic resonance imaging: a predictor of in vitro fertilization implantation failure. J Obstet Gynaecol Res. 2010 Jun;36 (3):611–8. DOI: 10.1111/j.1447–0756.2010.01189.x</mixed-citation><mixed-citation xml:lang="en">Maubon A, Faury A, Kapella M, Pouquet M, Piver P. Uterine junctional zone at magnetic resonance imaging: a predictor of in vitro fertilization implantation failure. J Obstet Gynaecol Res. 2010 Jun;36 (3):611–8. DOI: 10.1111/j.1447–0756.2010.01189.x</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Vercellini P, Consonni D, Dridi D, Bracco B, Frattaruolo MP, Somigliana E. Uterine adenomyosis and in vitro Fertilization outcome: a systematic review and meta-analysis. Hum Reprod. 2014 May;29 (5):964–77. DOI: 10.1093/humrep/deu041.</mixed-citation><mixed-citation xml:lang="en">Vercellini P, Consonni D, Dridi D, Bracco B, Frattaruolo MP, Somigliana E. Uterine  adenomyosis  and  in  vitro  Fertilization outcome: a systematic review and meta-analysis. Hum Reprod. 2014 May;29 (5):964–77. DOI: 10.1093/humrep/deu041.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Озерская И. А. Эхография в гинекологии. М.: Видар, 2013, 564 с.</mixed-citation><mixed-citation xml:lang="en">Ozerskaya IA. Ekhografiya v ginekologii [Echography in gynecology]. Мoscow: «Vidar» Publ., 2013, 564 p.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Naftalin J. Jurkovic D. The endometrial-myometrial junction: a fresh look at a busy crossing. Ultrasound Obstet Gynecol. 2009 Jul;34 (1):1–11. DOI: 10.1002/uog.6432.</mixed-citation><mixed-citation xml:lang="en">Naftalin J. Jurkovic D. The     endometrial-myometrial     junction: a fresh look at a busy crossing. Ultrasound Obstet Gynecol. 2009 Jul;34 (1):1–11. DOI: 10.1002/uog.6432.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Exacoustos C, Brienza L, Di Giovanni A, Szabolcs B, Romanini ME, Zupi E, Arduini D. Adenomyosis: three-dimensional sonographic findings of the junctional zone and correlation with histology. Ultrasound Obstet Gynecol. 2011 Apr;37 (4):471–9. DOI: 10.1002/uog.8900.</mixed-citation><mixed-citation xml:lang="en">Exacoustos C, Brienza L, Di Giovanni A, Szabolcs B, Romanini ME,  Zupi  E,  Arduini D. Adenomyosis:  three-dimensional  sonographic findings of the junctional zone and correlation with histology. Ultrasound Obstet Gynecol. 2011 Apr;37 (4):471–9. DOI: 10.1002/uog.8900.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Малышкина Д. А., Нагорный С. Н., Герасимов А. М. Эффективность дооперационной диагностики распространенных форм эндометриоза. Медико-биологические, клинические и социальные вопросы здоровья и патологии человека. 2016, с. 145–147.</mixed-citation><mixed-citation xml:lang="en">Malyshkina  DA,  Nagornyi  SN,  Gerasimov  AM. Effektivnost’ dooperatsionnoi diagnostiki rasprostranennykh form endometrioza. Mediko-biologicheskie, klinicheskie i sotsial’nye voprosy zdorov’ya  i patologii  cheloveka  [Efficiency of preoperative diagnosis of common forms of endometriosis. Medico-biological, clinical and social issues of human health and pathology]. 2016, pp. 145–147. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Champaneria R, Abedin P, Daniels J, Balogun M, Khan KS. Ultrasound scan and magnetic resonance imaging for the diagnosis of adenomyosis: systematic review comparing test accuracy. Acta Obstet Gynecol Scand. 2010 Nov;89 (11):1374–84. DOI: 10.3109/00016349.2010.512061</mixed-citation><mixed-citation xml:lang="en">Champaneria R, Abedin P, Daniels J, Balogun M, Khan KS. Ultrasound scan and magnetic resonance imaging for the diagnosis of adenomyosis: systematic review comparing test accuracy. Acta  Obstet  Gynecol  Scand.  2010  Nov;89  (11):1374–84.  DOI: 10.3109/00016349.2010.512061</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Ярмолинская М. И., Русина Е. И., Хачатурян А. Р., Флорова М. С. Клиника и диагностика генитального эндометриоза. Журнал акушерства и женских болезней. 2016; 65 (5): 4–21. DOI: 10.17816/JOWD6554–21</mixed-citation><mixed-citation xml:lang="en">Yarmolinskaya  MI,  Rusina  EI,  Khachaturyan  AR,  Florova MS. Clinical picture and diagnosis of genital endometriosis. Journal of Obstetrics and Woman Disease. 2016; 65 (5): 4–21. DOI: 10.17816/JOWD6554–21 (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Sofic A, Husic-Selimovic A, Carovac A, Jahic E, Smailbegovic V, Kupusovic J. The Significance of MRI Evaluation of the Uterine Junctional Zone in the Early Diagnosis of Adenomyosis. Acta Inform Med. 2016 Apr;24 (2):103–6. DOI: 10.5455/aim.2016.24.103–106</mixed-citation><mixed-citation xml:lang="en">Sofic  A,  Husic-Selimovic  A,  Carovac  A,  Jahic  E,  Smailbegovic  V,  Kupusovic J. The  Significance  of  MRI  Evaluation  of the Uterine Junctional Zone in the Early Diagnosis of Adenomyosis.  Acta  Inform  Med.  2016  Apr;24  (2):103–6.  DOI: 10.5455/aim.2016.24.103–106</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Tamai K, Koyama K, Umeoka S, Saga T, Fujii S, Togashi K. Spectrum of MR features in adenomyosis. Best Pract Res Clin Obstet Gynaecol. 2006 Aug;20 (4):583–602. DOI: 10.1016/j.bpobgyn.2006.01.009</mixed-citation><mixed-citation xml:lang="en">Tamai K, Koyama K, Umeoka S, Saga T, Fujii S, Togashi K. Spectrum of MR features in adenomyosis. Best Pract Res Clin Obstet Gynaecol. 2006 Aug;20 (4):583–602. DOI: 10.1016/j.bpobgyn.2006.01.009</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Tocci A, Greco E, Ubaldi FM. Adenomyosis and «endometrialsubendometrial myometrium unit disruption disease» are two different entities. Reprod Biomed Online. 2008 Aug;17 (2):281–91.</mixed-citation><mixed-citation xml:lang="en">Tocci A, Greco E, Ubaldi FM. Adenomyosis and «endometrial-subendometrial myometrium unit disruption disease» are two different entities. Reprod Biomed Online. 2008 Aug;17 (2):281–91.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Di Donato N, Bertoldo V, Montanari G, Zannoni L, Caprara G, Seracchioli R. A simple sonographic sign associated to the presence of adenomyosis. Ultrasound Obstet Gynecol. 2015 Jul;46 (1):126–7. DOI: 10.1002/uog.14750</mixed-citation><mixed-citation xml:lang="en">Di Donato N, Bertoldo V, Montanari G, Zannoni L, Caprara G, Seracchioli R. A simple sonographic sign associated to the presence of adenomyosis. Ultrasound Obstet Gynecol. 2015 Jul;46 (1):126–7. DOI: 10.1002/uog.14750</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Радзинский В. Е., Сорокина А. В., Зиганшин Р. Х., Арапиди Г. П. Аденомиоз — болезнь загадок и предположений. Перспективы постгеномных исследований. Dоктор.Ру. Общая эндокринология. 2011; 9–2 (68): 27–30.</mixed-citation><mixed-citation xml:lang="en">Radzinsky VE, Sorokina AV, Ziganshin RKh, Arapidi GP. Adenomyosis: Disease of Mysteries and Suppositions. Perspectives of Postgenomic Researches. Doctor.Ru. 2011; 9–2 (68): 27–30. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson NL, Anderson NG. The human plasma proteome: history, character, and diagnostic prospects. Mol Cell Proteomics. 2002 Nov;1 (11):845–67.</mixed-citation><mixed-citation xml:lang="en">Anderson NL, Anderson NG. The human plasma proteome: history, character, and diagnostic prospects. Mol Cell Proteomics. 2002 Nov;1 (11):845–67.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson NP, Hummelshoj L; World Endometriosis Society Montpellier Consortium. Consensus on current management of endometriosis. Hum Reprod. 2013 Jun;28 (6):1552–68. DOI: 10.1093/humrep/det050</mixed-citation><mixed-citation xml:lang="en">Johnson  NP,  Hummelshoj  L;  World  Endometriosis  Society Montpellier  Consortium.  Consensus  on  current  management of endometriosis. Hum Reprod. 2013 Jun;28 (6):1552–68. DOI: 1093/humrep/det050</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Brosens I, Brosens JJ, Fusi L, Al-Sabbagh M, Kuroda K, Benagiano G. Risks of adverse pregnancy outcome in endometriosis. Fertil Steril. 2012 Jul;98 (1):30–5. DOI: 10.1016/j.fertnstert.2012.02.024</mixed-citation><mixed-citation xml:lang="en">Brosens  I,  Brosens  JJ,  Fusi  L,  Al-Sabbagh  M,  Kuroda  K, Benagiano G. Risks of adverse pregnancy outcome in endometriosis. Fertil Steril. 2012 Jul;98 (1):30–5. DOI: 10.1016/j.fertnstert.2012.02.024</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Sallam HN, Garcia-Velasco JA, Dias S, Arici A. Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis. Cochrane Database Syst Rev. 2006 Jan 25; (1): CD004635. DOI: 10.1002/14651858.CD004635.pub2</mixed-citation><mixed-citation xml:lang="en">Sallam HN, Garcia-Velasco JA, Dias S, Arici A. Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis. Cochrane Database Syst Rev. 2006 Jan 25; (1): CD004635. DOI: 10.1002/14651858.CD004635.pub2</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Imaoka I, Ascher SM, Sugimura K, Takahashi K, Li H, Cuomo F, Simon J, Arnold LL. MR imaging of diffuse adenomyosis changes after GnRH analog therapy. J Magn Reson Imaging. 2002 Mar;15 (3):285–90. DOI: 10.1002/jmri.10060</mixed-citation><mixed-citation xml:lang="en">Imaoka I, Ascher SM, Sugimura K, Takahashi K, Li H, Cuomo F, Simon J, Arnold LL. MR imaging of diffuse adenomyosis changes after GnRH analog therapy. J Magn Reson Imaging. 2002 Mar;15 (3):285–90. DOI: 10.1002/jmri.10060</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Hughes E, Brown J, Collins JJ, Farquhar C, Fedorkow DM, Vandekerckhove P. Ovulation suppression for endometriosis. Cochrane Database Syst Rev. 2007 Jul 18; (3): CD000155. DOI: 10.1002/14651858.CD000155.pub2</mixed-citation><mixed-citation xml:lang="en">Hughes E, Brown J, Collins JJ, Farquhar C, Fedorkow DM, Vandekerckhove P. Ovulation   suppression   for   endometriosis. Cochrane Database Syst Rev. 2007 Jul 18; (3): CD000155. DOI: 10.1002/14651858.CD000155.pub2</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Доброхотова Ю. Э., Ильина И. Ю. Положительное влияние вагинальной гормональной системы на контроль менструального цикла. Вопросы гинекологии, акушерства и перинатологии. 2010; 9 (5): 75–77.</mixed-citation><mixed-citation xml:lang="en">Dobrokhotova YuE, Il’ina IYu. A positive effect of the vaginal hormonal system on control of the menstrual cycle. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2010; 9 (5): 75–77. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Sitruk-Ware R, El-Etr M. Progesterone and related progestins: potential new health benefits. Climacteric. 2013 Aug;16 Suppl 1:69–78. DOI: 10.3109/13697137.2013.802556</mixed-citation><mixed-citation xml:lang="en">Sitruk-Ware R, El-Etr M. Progesterone and related progestins: potential new health benefits. Climacteric. 2013 Aug;16 Suppl 1:69–78. DOI: 10.3109/13697137.2013.802556</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Laschke MW, Menger MD. Anti-angiogenetic treatment strategies for the therapy of endometriosis. Hum Reprod Update. 2012 Nov-Dec;18 (6):682–702. DOI: 10.1093/humupd/dms026</mixed-citation><mixed-citation xml:lang="en">Laschke MW, Menger MD. Anti-angiogenetic treatment strategies for the therapy of endometriosis. Hum Reprod Update. 2012 Nov-Dec;18 (6):682–702. DOI: 10.1093/humupd/dms026</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Доброхотова Ю. Э., Гришин И. И., Ибрагимова Д. М., Нуруллин Р. Ф. Опыт применения Визанны у пациенток с диагностированным эндометриозом. Проблемы репродукции. 2014; 3: 33–35.</mixed-citation><mixed-citation xml:lang="en">Dobrokhotova  IuÉ,  Grishin  IG,  Ibragimova  DM,  Nurullin RF. The experience of Visanne use in patients with endometriosis. Problemy reproduktsii (Russian Journal of Human Reproduction). 2014; 3: 33–35. (In Russian).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
