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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rpmj</journal-id><journal-title-group><journal-title xml:lang="ru">Research'n Practical Medicine Journal</journal-title><trans-title-group xml:lang="en"><trans-title>Research and Practical Medicine Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2410-1893</issn><publisher><publisher-name>"QUASAR", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17709/2409-2231-2017-4-4-13</article-id><article-id custom-type="elpub" pub-id-type="custom">rpmj-227</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клинические наблюдения</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical Case Reports</subject></subj-group></article-categories><title-group><article-title>ПЕРВЫЙ  РОССИЙСКИЙ  ОПЫТ ИНТРАОПЕРАЦИОННОЙ УЛЬТРАЗВУКОВОЙ   НАВИГАЦИИ  С КОНТРАСТНЫМ УСИЛЕНИЕМ ПРИ ВЫПОЛНЕНИИ РЕЗЕКЦИЙ  ПЕЧЕНИ ПО ПОВОДУ ЗЛОКАЧЕСТВЕННЫХ ОПУХОЛЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>FIRST RUSSIAN  EXPERIENCE OF USING CONTRAST-ENHANCED  INTRAOPERATIVE  ULTRASONOGRAPHY  (CE-IOUS) IN THE TREATMENT OF LIVER LESIONS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сидоров</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sidorov</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сидоров Дмитрий Владимирович доктор медицинских наук, руководитель отделения абдоминальной онкологии.</p><p>125284, Москва, 2-й Боткинский проезд, д. 3</p></bio><bio xml:lang="en"><p>Dmitry  V. Sidorov - MD, head of the Department of Abdominal Oncology.</p><p>3, 2nd Botkinskiy proezd, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степанов</surname><given-names>С. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Stepanov</surname><given-names>S. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Степанов Станислав Олегович доктор медицинских наук, руководитель отделения ультразвуковой диагностики.</p><p>125284, Москва, 2-й Боткинский проезд, д. 3</p></bio><bio xml:lang="en"><p>Stanislav  O. Stepanov - MD, Head of the Department  of Ultrasound Diagnostics.</p><p>3, 2nd Botkinskiy proezd, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ложкин</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lozhkin</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ложкин Михаил Владимирович  кандидат медицинских наук, ведущий научный сотрудник отделения  абдоминальной  онкологии.</p><p>125284, Москва, 2-й Боткинский проезд, д. 3</p></bio><bio xml:lang="en"><p>Mikhail  V. Lozhkin - PhD, Leading Researcher,  Department  of Abdominal Oncology.</p><p>3, 2nd Botkinskiy proezd, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петров</surname><given-names>Л. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrov</surname><given-names>L. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петров Леонид Олегович кандидат медицинских наук, старший научный сотрудник отделения абдоминальной онкологии.</p><p>125284, Москва, 2-й Боткинский проезд, д. 3</p></bio><bio xml:lang="en"><p>Leonid O. Petrov - PhD, Senior Researcher,  Department of Abdominal Oncology.</p><p>3, 2nd Botkinskiy proezd, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Митина</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mitina</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Митина Лариса Анатольевна доктор медицинских наук, ведущий  научный сотрудник отделения  ультразвуковой диагностики.</p><p>125284, Москва, 2-й Боткинский проезд, д. 3</p></bio><bio xml:lang="en"><p>Larisa  A. Mitina – MD, leading researcher,  Department of Ultrasound Diagnostics.</p><p>3, 2nd Botkinskiy proezd, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гуц</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Guts</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гуц Ольга Владимировна кандидат медицинских наук, научный сотрудник отделения ультразвуковой диагностики.</p><p>125284, Москва, 2-й Боткинский проезд, д. 3</p></bio><bio xml:lang="en"><p>Olga  V. Guts - PhD, Senior Researcher,  Department of Ultrasound Diagnostics.</p><p>3, 2nd Botkinskiy proezd, Moscow, 125284</p></bio><email xlink:type="simple">olyagoots@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Исаева</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Isaeva</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Исаева Аиша Гасановна клинический ординатор отделения  абдоминальной  онкологии.</p><p>125284, Москва, 2-й Боткинский проезд, д. 3</p></bio><bio xml:lang="en"><p>Aisha G. Isaeva - clinical resident  of the Department  of Abdominal Oncology.</p><p>3, 2nd Botkinskiy proezd, Moscow, 125284</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский научно-исследовательский  онкологический институт  им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии»  Министерства здравоохранения  Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>P. Hertsen Moscow Oncology Research  Institute – Branch of the National Medical Radiology Research  Centre of the Ministry of Health of the Russian</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>13</day><month>12</month><year>2017</year></pub-date><volume>4</volume><issue>4</issue><fpage>125</fpage><lpage>132</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сидоров Д.В., Степанов С.О., Ложкин М.В., Петров Л.О., Митина Л.А., Гуц О.В., Исаева А.Г., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Сидоров Д.В., Степанов С.О., Ложкин М.В., Петров Л.О., Митина Л.А., Гуц О.В., Исаева А.Г.</copyright-holder><copyright-holder xml:lang="en">Sidorov D.V., Stepanov S.O., Lozhkin M.V., Petrov L.O., Mitina L.A., Guts O.V., Isaeva A.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpmj.ru/rpmj/article/view/227">https://www.rpmj.ru/rpmj/article/view/227</self-uri><abstract><p>На сегодняшний день сложно представить медицинскую практику без современных визуализационных методов инструментальной диагностики. В это же время, по оценкам Всемирной организации здравоохранения, две трети мировой популяции лишены таких возможностей. Ультразвуковая диагностика с внутривенным контрастированием (CEUS), требующая минимальных финансовых затрат и технического оснащения, обладает большим потенциалом исправить эту ситуацию. В настоящее время растет интерес к использованию эхографии с контрастным усилением с целью улучшения эффективности выявления очаговой патологии и точности дифференциальной диагностики, в том числе в хирургической гепатологии.</p><p>Хорошо известны трудности при планировании хирургической тактики у пациентов при метастатическом колоректальным раке печени (расхождение данных предоперационных методов лучевой диагностики о количестве и посегментной локализации очагов в печени, вероятность наличия дополнительных очагов). Золотой стандарт диагностической оценки, сочетающий пальпацию печени и выполнение интраоперационного ультразвукового исследования (ИОУЗИ), в настоящее время дополнен возможностью контрастного усиления в процессе интраоперационной эхографии.</p><p>В данной статье мы приводим описание метода ультразвуковой диагностики с внутривенным (в/в) контрастированием, проиллюстрировав возможности исследования клиническими случаями применения интраоперационной ультразвуковой диагностики с контрастным усилением у пациентов с метастатическим раком печени.</p><p>Наши впечатления о возможностях УЗИ с в/в контрастированием в интраоперационной диагностике опухолевых очагов у пациентов с метастатическими раком печени мы строим на этом небольшом опыте.</p></abstract><trans-abstract xml:lang="en"><p>For today it is difficult to imagine medical practice without modern visualization methods of instrumental diagnostics. At the same time, according to the estimates of the World Health Organization, two-thirds of the world population is deprived of such opportunities. Ultrasound diagnostics with intravenous contrasting (CEUS), which requires minimal financial costs and technical equipment, has a great potential to remedy this situation. At present, there is a growing interest in the use of echography with contrast enhancement in order to improve the efficiency of detecting focal pathology and the accuracy of differential diagnosis, incl. in surgical hepatology.</p><p>Difficulties in planning the surgical tactics in patients with metastatic colorectal liver cancer are well known (discrepancy in the data of preoperative methods of radiation diagnosis about the number and segmental location of foci in the liver, the probability of additional foci). The “gold standard” of the diagnostic evaluation, which combines palpation of the liver and the performance of intraoperative ultrasound (IOUS), is now supplemented by the possibility of contrast enhancement during intraoperative echography.</p><p>In this article, we present a description of the method of ultrasound diagnostics with intravenous (IV) contrasting, illustrating the possibilities of investigation by clinical cases of intraoperative ultrasound diagnostics with contrast enhancement in patients with metastatic liver cancer.</p><p>Our impressions about the possibilities of ultrasound with intravenous contrast in the intraoperative diagnosis of tumor foci in patients with metastatic liver cancer we build on this little experience.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>CEUS</kwd><kwd>метастатический рак печени</kwd><kwd>интраоперационная диагностика</kwd><kwd>внутривенный контраст</kwd><kwd>Соновью</kwd></kwd-group><kwd-group xml:lang="en"><kwd>CEUS</kwd><kwd>metastatic liver cancer</kwd><kwd>intraoperative diagnosis</kwd><kwd>intravenous contrast</kwd><kwd>Sonoview</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Greis C. 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