rpmjResearch'n Practical Medicine JournalResearch and Practical Medicine Journal2410-1893"QUASAR", LLC10.17709/2409-2231-2019-6-2-7rpmj-401Research ArticleОбзорReviewФАКТОРЫ ПРОГНОЗА РЕЗЕКТАБЕЛЬНОГО РАКА ОБЩЕГО ЖЕЛЧНОГО ПРОТОКАPROGNOSTIC FACTORS FOR RESECTABLE COMMON BILE DUCT CANCERhttps://orcid.org/0000-0001-7163-2089СысковаА. Ю.SyskovaA. Yu.

аспирант кафедры онкологии и лучевой терапии лечебного факультета;   аспирант отделения опухолей печени и поджелудочной железы

117997,  г. Москва, ул. Островитянова, д. 1;   115478, Москва, Каширское шоссе, д. 23

PhD student, department of oncology and radiation therapy, faculty of therapy; , graduate student in the department of liver and pancreas tumors

1 Ostrovityanova str., Moscow 1 17997; 23 Kashirskoe sh., 1 15478

СтилидиИ. С.StilidiI. S.

член-корреспондент РАН, д. м.н., профессор, заведующий кафедрой онкологии и лучевой терапии лечебного факультета ;  директор 

117997,  г. Москва, ул. Островитянова, д. 1;   115478, Москва, Каширское шоссе, д. 23

corr. member of RAS, MD, PhD, DSc, professor, head of the department of oncology and radiotherapy of the medical faculty ; Director

1 Ostrovityanova str., Moscow 1 17997; 23 Kashirskoe sh., 1 15478

https://orcid.org/0000-0001-5348-5011ПоляковА. Н.PolyakovA. N.

 к. м.н., старший научный сотрудник отделения опухолей печени и поджелудочной железы 

115478, Москва, Каширское шоссе, д. 23

MD, PhD, senior researcher, department of liver and pancreas tumors

23 Kashirskoe sh., 1 15478

ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Министерства здравоохранения Российской Федерации; ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н.Блохина» Министерства здравоохранения Российской ФедерацииРоссияPirogov Russian National Research Medical University (RNRMU) of the Health Ministry of Russia; N.N.BLokhin National Medical Research Centre of Oncology of the Health Ministry of RussiaRussian FederationФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н.Блохина» Министерства здравоохранения Российской ФедерацииРоссияN.N.BLokhin National Medical Research Centre of Oncology of the Health Ministry of RussiaRussian Federation201927062019626974Copyright © Сыскова А.Ю., Стилиди И.С., Поляков А.Н., 20192019Сыскова А.Ю., Стилиди И.С., Поляков А.Н.Syskova A.Y., Stilidi I.S., Polyakov A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpmj.ru/rpmj/article/view/401

Рак общего желчного протока – редкое злокачественное заболевание с неблагоприятным прогнозом. Пятилетняя общая выживаемость составляет 18–48%, и более половины пациентов подвержены рецидиву в течение пяти лет.

Метастазы в регионарных лимфоузлах и наличие опухолевых клеток в крае резекции – независимые факторы негативного прогноза, ассоциирующиеся с высоким риском возникновения рецидива. Клиническая значимость других факторов прогноза, таких как периневральная инвазия, низкая степень дифференцировки, размер опухоли, инвазия в поджелудочную железу и необходимость выполнения резекции смежных органов, требует дальнейшего изучения.

Common bile duct cancer is a rare malignant disease with a poor prognosis. Five-year overall survival is 18-48%, and more than half of the patients relapse within five years.

Metastases in the regional lymph nodes and the presence of tumor cells in the margin of the resection are independent factors of a negative prognosis and are associated with a high risk of recurrence.

The clinical significance of other prognostic factors, such as renal invasion, low degree of differentiation, tumor size, pancreatic invasion and the need for resection of adjacent organs, require further study.

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The authors declare that there are no conflicts of interest present.