rpmjResearch'n Practical Medicine JournalResearch and Practical Medicine Journal2410-1893"QUASAR", LLC10.17709/2409-2231-2019-6-3-7rpmj-423Research ArticleОбзорыReviewАУТОПЛАЗМА, ОБОГАЩЕННАЯ ТРОМБОЦИТАРНЫМИ ФАКТОРАМИ РОСТА, В ЛЕЧЕНИИ ЭРЕКТИЛЬНОЙ ДИСФУНКЦИИ: ОБЗОР ДОКЛИНИЧЕСКИХ И КЛИНИЧЕСКИХ ИССЛЕДОВАНИЙPLATELET-RICH PLASMA THERAPY FOR ERECTILE DYSFUNCTION: A REVIEW OF PRECLINICAL AND CLINICAL STUDIEShttps://orcid.org/0000-0001-8784-8415КапринА. Д.KaprinA. D.

академик РАН, д.м. н., профессор, заведующий кафедрой урологии и оперативной нефрологии с курсом онкоурологии Медицинского института РУДН, генеральный директор ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации

academician of RAS, MD, PhD, professor, head of the department of urology and operative nephrology with oncourology course of the Medical Institute of Peoples’ Friendship University (RUDN University), General Director of National Medical Radiology Research Centre of the Ministry of Health of the Russian Federation

https://orcid.org/0000-0002-0792-6012КостинА. А.KostinA. A.

д.м .н., профессор, заведующий кафедры урологии с курсами онкоурологии, радиологии и андрологии факультета непрерывного медицинского образования ФГАОУ ВО «Российский университет дружбы народов», первый заместитель генерального директора ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации

MD, PhD, DSc, professor, head of the department of urology with oncology, radiology and andrology courses of the Continuing Medical Education of Peoples’ Friendship University (RUDN University), Deputy Director of National Medical Radiology Research Centre of the Ministry of Health of the Russian Federation

https://orcid.org/0000-0002-8398-7255ЕпифановаМ. В.EpifanovaM. V.

к. м.н., доцент кафедры урологии и оперативной нефрологии с курсом онкоурологии Медицинского института ФГАОУ ВО «Российский университет дружбы народов», доцент кафедры урологии с курсами онкоурологии, радиологии и андрологии факультета непрерывного медицинского образования ФГАОУ ВО «Российский университет дружбы народов»

MD, PhD, associate professor at the department of urology and operative nephrology with oncourology course of the Medical Institute of Peoples’ Friendship University of Russia (RUDN University), associate professor at the department of urology with oncology, radiology and andrology courses of the Continuing Medical Education of Peoples’ Friendship University (RUDN University)

epifanova_maya@mail.ruЧалыйМ. Е.ChalyyM. E.

д .м.н., профессор, ведущий научный сотрудник Медицинского научно-образовательного центра

MD, PhD, DSc, professor, leading researcher

ГамееваЕ. В.GameevaE. V.

к.м.н., заместитель директора по лечебной работе

MD, PhD, deputy director for medical work

https://orcid.org/0000-0002-3630-9427АртеменкоС. А.ArtemenkoS. A.

студент 6‑го курса Международной школы «Медицина Будущего» Научно-технологического парка биомедицины

sixth year student, International School «Medicine of the Future»

ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации; Медицинский институт ФГАОУ ВО «Российский университет дружбы народов»РоссияNational Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; Medical Institute of Peoples' Friendship University of Russia (RUDN University)Russian FederationФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации; ФГАОУ ВО «Российский университет дружбы народов»РоссияNational Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; Peoples' Friendship University of Russia (RUDN University)Russian FederationМедицинский институт ФГАОУ ВО «Российский университет дружбы народов; ФГАОУ ВО «Российский университет дружбы народов»РоссияMedical Institute of Peoples' Friendship University of Russia (RUDN University) Peoples' Friendship University of Russia (RUDN University)Russian FederationМедицинский научно-образовательный центр ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»РоссияMedical Research and Education Center of Lomonosov Moscow State UniversityRussian FederationМосковский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской ФедерацииРоссияP. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский университет)РоссияI.M.Sechenov First Moscow State Medical University (Sechenov University)Russian Federation201904092019637486Copyright © Каприн А.Д., Костин А.А., Епифанова М.В., Чалый М.Е., Гамеева Е.В., Артеменко С.А., 20192019Каприн А.Д., Костин А.А., Епифанова М.В., Чалый М.Е., Гамеева Е.В., Артеменко С.А.Kaprin A.D., Kostin A.A., Epifanova M.V., Chalyy M.E., Gameeva E.V., Artemenko S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpmj.ru/rpmj/article/view/423

Эректильная дисфункция (ЭД) давно перестала быть только психосоциальной проблемой. Сегодня это маркер сердечно-сосудистых заболеваний. Применение аутоплазмы, обогащенной тромбоцитарными факторами роста (АОТ), является новым и многообещающим методом, заслуживающим внимания специалистов. В обзоре представлены существующие на данный момент доклинические и клинические исследования, опубликованные в базах данных PubMed, Cochrane Library, Clinicaltrials.gov, по применению АОТ в лечении ЭД. Имеющиеся данные доклинических и клинических исследований говорят об эффективности использования данной методики для лечения ЭД и отсутствии побочных эффектов. АОТ является патогенетически обоснованным методом лечения ЭД, который направлен на репарацию и регенерацию эндотелия, гладкомышечных клеток и соединительной ткани. Однако для формирования систематического обзора и метаанализа необходимо проведение большего числа крупных плацебо-контролируемых многоцентровых исследований.

Erectile dysfunction is no longer a psychosocial problem. Nowadays, it is a marker specific for the initial stages of cardiovascular diseases. Рlatelet-rich plasma (PRP) is a new and promising method, which totally deserves to be noted by specialists. To review currently existing pre-clinical and clinical studies concerning application of PRP in erectile dysfunction published in international sources such as PubMed, Cochrane Library, Clinicaltrials.gov. The current data of preclinical and clinical studies determine the absence of PRP side effects and the effectiveness for ED treatment. PRP-therapy is a pathogenetically substantiated method of treating erectile dysfunction. The therapy is designed for repair and regeneration of endothelium, smooth muscle cells, and connective tissue. However, large, placebo-controlled, multicenter studies are needed to creation a systematic review and meta-analysis.

аутоплазмаобогащенная тромбоцитарными факторами роста (АОТ)эректильная дисфункция (ЭД)сексуальная дисфункцияэректильная функция (ЭФ)факторы ростаклеточная терапияplatelet-rich plasma (PRP)erectile dysfunction (ED)sexual dysfunctionerectile functionregenerative medicinegrowth factorscell therapyФинансирование данной работы не проводилось.No funding of this work has been held.ReferencesColson MH, Cuzin B, Faix A, Grellet L, Huyghes E. Erectile dysfunction : up-date data and clinical guidelines. Rev Med Suisse. 2019 Mar 13;15 (642):583–589. [Article in French].Colson MH, Cuzin B, Faix A, Grellet L, Huyghes E. Erectile dysfunction : up-date data and clinical guidelines. Rev Med Suisse. 2019 Mar 13;15 (642):583–589. [Article in French].Shaeer O, Shaeer K. The Global Online Sexuality Survey (GOSS): the United States of America in 2011. Chapter I: erectile dysfunction among English-speakers. J Sex Med. 2012 Dec;9 (12):3018–27. DOI: 10.1111/j.1743–6109.2012.02976.xShaeer O, Shaeer K. 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The authors declare that there are no conflicts of interest present.