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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rpmj</journal-id><journal-title-group><journal-title xml:lang="ru">Research'n Practical Medicine Journal</journal-title><trans-title-group xml:lang="en"><trans-title>Research and Practical Medicine Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2410-1893</issn><publisher><publisher-name>"QUASAR", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17709/2409-2231-2019-6-3-8</article-id><article-id custom-type="elpub" pub-id-type="custom">rpmj-424</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Review</subject></subj-group></article-categories><title-group><article-title>ФИТОТЕРАПИЯ ПРИ ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЯХ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ</article-title><trans-title-group xml:lang="en"><trans-title>PHYTOTHERAPY FOR INFLAMMATORY DISEASES OF THE PROSTATE</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4468-3670</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кульченко</surname><given-names>Н. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulchenko</surname><given-names>N. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м. н., врач-уролог, врач ультразвуковой диагностики, старший преподаватель кафедры гистологии, цитологии и эмбриологии</p></bio><bio xml:lang="en"><p>MD, PhD, urologist, ultrasound medical specialist, senior lectures of the departments of histology, cytology and embryology</p></bio><email xlink:type="simple">kle-kni@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7255-6679</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яценко</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Yatsenko</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м .н., врач-уролог, врач ультразвуковой диагностики, заместитель главного врача по медицинской части</p></bio><bio xml:lang="en"><p>MD, PhD, urologist, ultrasound medical specialist, deputy chief physician</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Медицинский институт ФГАОУ ВО «Российский университет дружбы народов»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Medical Institute of Peoples' Friendship University of Russia (RUDN University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Медицинский центр «МедиКос» ООО ПКФ «ДОММ»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Medical Clinic “MediCos”</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>04</day><month>09</month><year>2019</year></pub-date><volume>6</volume><issue>3</issue><fpage>87</fpage><lpage>97</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кульченко Н.Г., Яценко Е.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Кульченко Н.Г., Яценко Е.В.</copyright-holder><copyright-holder xml:lang="en">Kulchenko N.G., Yatsenko E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpmj.ru/rpmj/article/view/424">https://www.rpmj.ru/rpmj/article/view/424</self-uri><abstract><p>В статье обсуждается эффективность фитотерапии при воспалительных заболеваниях предстательной железы. В данном обзоре литературы приведены клинические исследования успешного использования растительных компонентов в лечении и профилактике хронического простатита и купировании симптомов нижних мочевыводящих путей (СНМП). Биологические активные вещества корня крапивы, семян тыквы, пальмы сабаль и цинка весьма эффективны в терапии хронического простатита за счет противовоспалительного, антипролиферативного, антиандрогенного и антиоксидантного действий. Фитопрепараты, содержащие эти вещества, могут быть рекомендованы в качестве первой линии коррекции СНМП при хроническом простите категорий III и IV; в качестве общеукрепляющего средства для мужчин, ведущих малоподвижный образ жизни в возрасте старше 35 лет.</p></abstract><trans-abstract xml:lang="en"><p>The article discusses the effectiveness of herbal medicine in inflammatory diseases of the prostate. This literature review presents clinical studies of the successful use of herbal ingredients in the treatment of chronic prostatitis and relief of lower urinary tract symptoms (LUTS). Biological active substances of Urtica dioica, Cucurbita moschata, Saw palmetto (Serenoa repens), and zinc are effective in the treatment of chronic prostatitis due to anti-inflammatory, antiproliferative, antiandrogenic and antioxidant action. Phytopreparations containing these substances can be recommended as the first line of correction of LUTS in chronic forgive categories III and IV; as a general tonic for men leading a sedentary lifestyle over the age of 35 years.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фитотерапия</kwd><kwd>хронический бактериальный простатит</kwd><kwd>экстракт корней крапивы</kwd><kwd>экстракт пальмы сабаль</kwd><kwd>экстракт семян тыквы</kwd><kwd>цинк</kwd><kwd>Serenoa repens</kwd><kwd>Saw palmetto</kwd><kwd>Urtica dioica</kwd><kwd>Cucurbita moschata</kwd><kwd>симптомы нижних мочевыводящих путей</kwd></kwd-group><kwd-group xml:lang="en"><kwd>phytotherapy</kwd><kwd>chronic bacterial prostatitis</kwd><kwd>Saw palmetto</kwd><kwd>Serenoa repens</kwd><kwd>Cucurbita moschata</kwd><kwd>Urtica dioica</kwd><kwd>zinc</kwd><kwd>lower urinary tract symptoms (LUTS)</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование проведено при поддержке компании «Си Эс Си Лтд». Спонсоры исследования и третьи лица не принимали участие в обработке и анализе данных и написании настоящей статьи.</funding-statement><funding-statement xml:lang="en">The research was carried out with the support of the “CSC Ltd” company. The study sponsors and the third parties have not been involved in the processing and analysis of the data and the writing of this article.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Pirola GM, Verdacchi T, Rosadi S, Annino F, De Angelis M. Chronic prostatitis: current treatment options. Res Rep Urol. 2019 Jun 4;11:165–174. DOI: 10.2147/RRU.S194679</mixed-citation><mixed-citation xml:lang="en">Pirola GM, Verdacchi T, Rosadi S, Annino F, De Angelis M. Chronic prostatitis: current treatment options. Res Rep Urol. 2019 Jun 4;11:165–174. DOI: 10.2147/RRU.S194679</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Clemens JQ, Meenan RT, O’Keeﬀe Rosetti MC, Kimes T, Calhoun EA. Prevalence of and risk factors for prostatitis: population based assessment using physician assigned diagnoses. J Urol. 2007 Oct;178 (4 Pt 1):1333–7. DOI: 10.1016/j.juro.2007.05.140</mixed-citation><mixed-citation xml:lang="en">Clemens JQ, Meenan RT, O’Keeﬀe Rosetti MC, Kimes T, Calhoun EA. Prevalence of and risk factors for prostatitis: population based assessment using physician assigned diagnoses. J Urol. 2007 Oct;178 (4 Pt 1):1333–7. DOI: 10.1016/j.juro.2007.05.140</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Nickel JC. Prostatitis. Canadian Urological Association Journal. 2011;5 (5):306–5. DOI: 10.5489/cuaj.11211</mixed-citation><mixed-citation xml:lang="en">Nickel JC. Prostatitis. Canadian Urological Association Journal. 2011;5 (5):306–5. DOI: 10.5489/cuaj.11211</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Pontari MA, Joyce GF, Wise M, McNaughton-Collins M. Urologic Diseases in America Project. Prostatitis. J Urol. 2007 Jun;177 (6):2050–7. DOI: 10.1016/j.juro.2007.01.128</mixed-citation><mixed-citation xml:lang="en">Pontari MA, Joyce GF, Wise M, McNaughton-Collins M. Urologic Diseases in America Project. Prostatitis. J Urol. 2007 Jun;177 (6):2050–7. DOI: 10.1016/j.juro.2007.01.128</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Аполихин О. И., Комарова В. А., Никушина А .А., Сивков А. В. Болезни предстательной железы в Российской Федерации: статистические данные 2008–2017 гг. Экспериментальная и клиническая урология. 2019;2:4–13. DOI: 10.29188/2222–8543–2019–11–2-4–12</mixed-citation><mixed-citation xml:lang="en">Apolihin OI, Komarova VA, Nikushina AA, Sivkov AV. Prostate diseases in the Russian Federation: statistical data for 2008– 2017. Experimental and Clinical Urology. 2019;2:4–13. DOI: 10.29188/2222–8543–2019–11–2-4–12 (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Krieger JN, Nyberg L Jr, Nickel JC. NIH consensus deﬁnition and classiﬁcation of prostatitis. JAMA. 1999 Jul 21;282 (3):236–7. DOI: 10.1001/jama.282.3.236</mixed-citation><mixed-citation xml:lang="en">Krieger JN, Nyberg L Jr, Nickel JC. NIH consensus deﬁnition and classiﬁcation of prostatitis. JAMA. 1999 Jul 21;282 (3):236–7. DOI: 10.1001/jama.282.3.236</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Виноградов И.В., Живулько А.Р., Короле в С.В. Хронический простатит, патогенетические механизмы влияния на мужскую фертильность. Вестник последипломного медицинского образования. 2018;4:48–54</mixed-citation><mixed-citation xml:lang="en">Vinogradov IV, Zhivulko AR, Korolev SV. Chronic prostatitis, pathogenetic mechanisms of inﬂuence on male fertility. Journal of Postgraduate Medical Education. 2018;4:48–54. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Stamatiou K, Pierris N. Serenoa repens extract additionally to quinolones in the treatment of chronic bacterial prostatitis. The preliminary results of a long term observational study. Arch Ital Urol Androl. 2013 Dec 31;85 (4):190–6. DOI: 10.4081/aiua.2013.4.190</mixed-citation><mixed-citation xml:lang="en">Stamatiou K, Pierris N. Serenoa repens extract additionally to quinolones in the treatment of chronic bacterial prostatitis. The preliminary results of a long term observational study. Arch Ital Urol Androl. 2013 Dec 31;85 (4):190–6. DOI: 10.4081/aiua.2013.4.190</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Wagenlehner FM, van Till JW, Magri V, Perletti G, Houbiers JG, Weidner W, Nickel JC. National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) symptom evaluation in multinational cohorts of patients with chronic prostatitis/chronic pelvic pain syndrome. Eur Urol. 2013 May;63 (5):953–9. DOI: 10.1016/j.eururo.2012.10.042</mixed-citation><mixed-citation xml:lang="en">Wagenlehner FM, van Till JW, Magri V, Perletti G, Houbiers JG, Weidner W, Nickel JC. National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) symptom evaluation in multinational cohorts of patients with chronic prostatitis/chronic pelvic pain syndrome. Eur Urol. 2013 May;63 (5):953–9. DOI: 10.1016/j.eururo.2012.10.042</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Капр ин А.Д., Кос тин А.А., П опов С.В. Медикаментозная терапия хронического простатита. Русский медицинский журнал. Медицинское обозрение. 2015;23 (17):1010–2</mixed-citation><mixed-citation xml:lang="en">Kaprin AD, Kostin AA, Popov SV. Medikamentoznaya terapiya khronicheskogo prostatita. RMJ (Russian Medical Journal). 2015;23 (17):1010–2. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Weidner W. Treating chronic prostatitis: antibiotics no, alpha-blockers maybe. Ann Intern Med. 2004 Oct 19;141 (8):639–40. DOI: 10.7326/0003–4819–141-8–200410190–00012</mixed-citation><mixed-citation xml:lang="en">Weidner W. Treating chronic prostatitis: antibiotics no, alpha-blockers maybe. Ann Intern Med. 2004 Oct 19;141 (8):639–40. DOI: 10.7326/0003–4819–141-8–200410190–00012</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Попов С.В. , Мазо Е.Б. Этиотропная терапия хронического бактериального простатита. Урология. 2008;3:36–41</mixed-citation><mixed-citation xml:lang="en">Popov SV, Mazo EВ. Etiotropic therapy of chronic bacterial prostatitis. Urology. 2008;3:36–41. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Cunha BA, Gran A, Raza M. Persistent extended-spectrum β-lactamase-positive Escherichia coli chronic prostatitis successfully treated with a combination of fosfomycin and doxycycline. Int J Antimicrob Agents. 2015 Apr;45 (4):427–9. DOI: 10.1016/j. ijantimicag.2014.12.019</mixed-citation><mixed-citation xml:lang="en">Cunha BA, Gran A, Raza M. Persistent extended-spectrum β-lactamase-positive Escherichia coli chronic prostatitis successfully treated with a combination of fosfomycin and doxycycline. Int J Antimicrob Agents. 2015 Apr;45 (4):427–9. DOI: 10.1016/j. ijantimicag.2014.12.019</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Magri V, Boltri M, Cai T, Colombo R, Cuzzocrea S, De Visschere P, et al. Multidisciplinary approach to prostatitis. Arch Ital Urol Androl. 2019 Jan 18;90 (4):227–248. DOI: 10.4081/aiua.2018.4.227</mixed-citation><mixed-citation xml:lang="en">Magri V, Boltri M, Cai T, Colombo R, Cuzzocrea S, De Visschere P, et al. Multidisciplinary approach to prostatitis. Arch Ital Urol Androl. 2019 Jan 18;90 (4):227–248. DOI: 10.4081/aiua.2018.4.227</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Engelmann U, Walther C, Bondarenko B, Funk P, Schlafke S. Efﬁcacy and safety of a combination of sabal and urtica extract in lower urinary tract symptoms. A randomized, double-blind study versus tamsulosin. Arzneimittelforschung. 2006;56 (3):222–9. DOI: 10.1055/s-0031–1296714</mixed-citation><mixed-citation xml:lang="en">Engelmann U, Walther C, Bondarenko B, Funk P, Schlafke S. Efﬁcacy and safety of a combination of sabal and urtica extract in lower urinary tract symptoms. A randomized, double-blind study versus tamsulosin. Arzneimittelforschung. 2006;56 (3):222–9. DOI: 10.1055/s-0031–1296714</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Hu M, Wazir J, Ullah R, Wang W, Cui X, Tang M, Zhou X. Phytotherapy and physical therapy in the management of chronic prostatitis-chronic pelvic pain syndrome. Int Urol Nephrol. 2019 Jul;51 (7):1081–1088. doi: 10.1007/s11255–019–02161-x</mixed-citation><mixed-citation xml:lang="en">Hu M, Wazir J, Ullah R, Wang W, Cui X, Tang M, Zhou X. Phytotherapy and physical therapy in the management of chronic prostatitis-chronic pelvic pain syndrome. Int Urol Nephrol. 2019 Jul;51 (7):1081–1088. doi: 10.1007/s11255–019–02161-x</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Saavedra MJ, Aires A, Dias C, Almeida JA, De Vasconcelos MC, Santos P, Rosa EA. Evaluation of the potential of squash pumpkin by-products (seeds and shell) as sources of antioxidant and bioactive compounds. J Food Sci Technol. 2015 Feb;52 (2):1008–15. DOI: 10.1007/s13197–013–1089–5</mixed-citation><mixed-citation xml:lang="en">Saavedra MJ, Aires A, Dias C, Almeida JA, De Vasconcelos MC, Santos P, Rosa EA. Evaluation of the potential of squash pumpkin by-products (seeds and shell) as sources of antioxidant and bioactive compounds. J Food Sci Technol. 2015 Feb;52 (2):1008–15. DOI: 10.1007/s13197–013–1089–5</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Safarinejad MR. Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. J Herb Pharmacother. 2005;5 (4):1–11</mixed-citation><mixed-citation xml:lang="en">Safarinejad MR. Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. J Herb Pharmacother. 2005;5 (4):1–11</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">De Monte C, Carradori S, Granese A, Di Pierro GB, Leonardo C, De Nunzio C. Modern extraction techniques and their impact on the pharmacological proﬁle of Serenoa repens extracts for the treatment of lower urinary tract symptoms. BMC Urol. 2014 Aug 11;14:63. DOI: 10.1186/1471–2490–14–63</mixed-citation><mixed-citation xml:lang="en">De Monte C, Carradori S, Granese A, Di Pierro GB, Leonardo C, De Nunzio C. Modern extraction techniques and their impact on the pharmacological proﬁle of Serenoa repens extracts for the treatment of lower urinary tract symptoms. BMC Urol. 2014 Aug 11;14:63. DOI: 10.1186/1471–2490–14–63</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Damiano R, Cai T, Fornara P, Franzese CA, Leonardi R, Mirone V. The role of Cucurbita pepo in the management of patients aﬀected by lower urinary tract symptoms due to benign prostatic hyperplasia: A narrative review. Arch Ital Urol Androl. 2016 Jul 4;88 (2):136–43. DOI: 10.4081/aiua.2016.2.136</mixed-citation><mixed-citation xml:lang="en">Damiano R, Cai T, Fornara P, Franzese CA, Leonardi R, Mirone V. The role of Cucurbita pepo in the management of patients aﬀected by lower urinary tract symptoms due to benign prostatic hyperplasia: A narrative review. Arch Ital Urol Androl. 2016 Jul 4;88 (2):136–43. DOI: 10.4081/aiua.2016.2.136</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Chrubasik JE, Roufogalis BD, Wagner H. A comprehensive review on the stinging nettle eﬀect and eﬃcacy proﬁles Part II: Urtica radix. Phytomedicine. 2007 Aug;14 (7–8):568–79. DOI:10.1016/j.phymed.2007.03.014</mixed-citation><mixed-citation xml:lang="en">Chrubasik JE, Roufogalis BD, Wagner H. A comprehensive review on the stinging nettle eﬀect and eﬃcacy proﬁles Part II: Urtica radix. Phytomedicine. 2007 Aug;14 (7–8):568–79. DOI: 10.1016/j.phymed.2007.03.014</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Кульченко Н.Г. Оптимизация подходов консервативной терапии доброкачественной гиперплазии предстательной железы ингибиторами 5-альфаредуктазы. Клинико-морфологическое исследование. Курский научно-практический вестник «Человек и его здоровье». 2012;1:101–6</mixed-citation><mixed-citation xml:lang="en">Kulchenko NG. Optimizing the conservative therapy of benign prostatic hyperplasia by inhibitors of 5–alfareductase. Clinical and morphological study. Kursk scientiﬁc and practical bulletin «Man and his health». 2012;1:101–6. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Yang J, Te AE. Saw palmetto and ﬁnasteride in the treatment of category-III prostatitis/chronic pelvic pain syndrome. Curr Urol Rep. 2005 Jul;6 (4):290–5</mixed-citation><mixed-citation xml:lang="en">Yang J, Te AE. Saw palmetto and ﬁnasteride in the treatment of category-III prostatitis/chronic pelvic pain syndrome. Curr Urol Rep. 2005 Jul;6 (4):290–5</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Gordon AE, Shaughnessy AF. Saw palmetto for prostate disorders. Am Fam Physician. 2003 Mar 15;67 (6):1281–3</mixed-citation><mixed-citation xml:lang="en">Gordon AE, Shaughnessy AF. Saw palmetto for prostate disorders. Am Fam Physician. 2003 Mar 15;67 (6):1281–3</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Colado-Velázquez J, Mailloux-Salinas P, Medina-Contreras JML, Cruz-Robles D, Bravo G. Eﬀect of Serenoa repens on oxidative stress, inﬂammatory and growth factors in obese wistar rats with benign prostatic hyperplasia. Phytother Res. 2015 Oct;29 (10):1525–31. DOI: 10.1002/ptr.5406</mixed-citation><mixed-citation xml:lang="en">Colado-Velázquez J, Mailloux-Salinas P, Medina-Contreras JML, Cruz-Robles D, Bravo G. Eﬀect of Serenoa repens on oxidative stress, inﬂammatory and growth factors in obese wistar rats with benign prostatic hyperplasia. Phytother Res. 2015 Oct;29 (10):1525–31. DOI: 10.1002/ptr.5406</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Penugonda K, Lindshield B. Fatty acid and phytosterol content of commercial saw palmetto supplements. Nutrients. 2013 Sep 13;5 (9):3617–33. DOI: 10.3390/nu5093617</mixed-citation><mixed-citation xml:lang="en">Penugonda K, Lindshield B. Fatty acid and phytosterol content of commercial saw palmetto supplements. Nutrients. 2013 Sep 13;5 (9):3617–33. DOI: 10.3390/nu5093617</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Procida G, Stancher B, Cateni F, Zacchigna M. Chemical composition and functional characterisation of commercial pumpkin seed oil. J Sci Food Agric. 2013 Mar 30;93 (5):1035–41. DOI: 10.1002/jsfa.5843</mixed-citation><mixed-citation xml:lang="en">Procida G, Stancher B, Cateni F, Zacchigna M. Chemical composition and functional characterisation of commercial pumpkin seed oil. J Sci Food Agric. 2013 Mar 30;93 (5):1035–41. DOI: 10.1002/jsfa.5843</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Tantawy SA, Elgohary HM, Kamel DM. Trans-perineal pumpkin seed oil phonophoresis as an adjunctive treatment for chronic nonbacterial prostatitis. Res Rep Urol. 2018 Sep 18;10:95–101. DOI: 10.2147/RRU.S167896</mixed-citation><mixed-citation xml:lang="en">Tantawy SA, Elgohary HM, Kamel DM. Trans-perineal pumpkin seed oil phonophoresis as an adjunctive treatment for chronic nonbacterial prostatitis. Res Rep Urol. 2018 Sep 18;10:95–101. DOI: 10.2147/RRU.S167896</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Hong H, Kim CS, Maeng S. Eﬀects of pumpkin seed oil and saw palmetto oil in Korean men with symptomatic benign prostatic hyperplasia. Nutr Res Pract. 2009 Winter;3 (4):323–7. DOI: 10.4162/nrp.2009.3.4.323</mixed-citation><mixed-citation xml:lang="en">Hong H, Kim CS, Maeng S. Eﬀects of pumpkin seed oil and saw palmetto oil in Korean men with symptomatic benign prostatic hyperplasia. Nutr Res Pract. 2009 Winter;3 (4):323–7. DOI: 10.4162/nrp.2009.3.4.323</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Guan Q, Zheng Y, Wei X, Wang S, Su B, Yu S. The Eﬀect of Flavonoids on Chronic Prostatitis: A Meta-analysis of Published Randomized Controlled Trials. J Natl Med Assoc. 2019 May 23. pii: S0027–9684 (19)30011–2. DOI: 10.1016/j.jnma.2019.04.007</mixed-citation><mixed-citation xml:lang="en">Guan Q, Zheng Y, Wei X, Wang S, Su B, Yu S. The Eﬀect of Flavonoids on Chronic Prostatitis: A Meta-analysis of Published Randomized Controlled Trials. J Natl Med Assoc. 2019 May 23. pii: S0027–9684 (19)30011–2. DOI: 10.1016/j.jnma.2019.04.007</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Schilcher H, Dunzendorfer U, Ascali F. D7-Sterols: the prostatotropic principle of pumpkin seeds. Urologe B. 1987;27:316–319</mixed-citation><mixed-citation xml:lang="en">Schilcher H, Dunzendorfer U, Ascali F. D7-Sterols: the prostatotropic principle of pumpkin seeds. Urologe B. 1987;27:316–319</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Abdel-Rahman MK. Eﬀect of pumpkin seed (Cucurbita pepo L) diets on benign prostatic hyperplasia (BPH): chemical and morphometric evaluation in rats. World J Chem. 2006;1 (1):33–40</mixed-citation><mixed-citation xml:lang="en">Abdel-Rahman MK. Eﬀect of pumpkin seed (Cucurbita pepo L) diets on benign prostatic hyperplasia (BPH): chemical and morphometric evaluation in rats. World J Chem. 2006;1 (1):33–40</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Moradi HR, Erfani Majd N, Esmaeilzadeh S, Fatemi Tabatabaei SR. The histological and histometrical eﬀects of Urtica dioica extract on rat’s prostate hyperplasia. Vet Res Forum. 2015 Winter;6 (1):23–9</mixed-citation><mixed-citation xml:lang="en">Moradi HR, Erfani Majd N, Esmaeilzadeh S, Fatemi Tabatabaei SR. The histological and histometrical eﬀects of Urtica dioica extract on rat’s prostate hyperplasia. Vet Res Forum. 2015 Winter;6 (1):23–9</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Pigat N, Reyes-Gomez E, Boutillon F, Palea S, Barry Delongchamps N, Koch E, Goﬃn V. Combined Sabal and Urtica Extracts (WS® 1541) Exert Anti-proliferative and Anti-inﬂammatory Effects in a Mouse Model of Benign Prostate Hyperplasia. Front Pharmacol. 2019 Mar 29;10:311. DOI: 10.3389/fphar.2019.00311</mixed-citation><mixed-citation xml:lang="en">Pigat N, Reyes-Gomez E, Boutillon F, Palea S, Barry Delongchamps N, Koch E, Goﬃn V. Combined Sabal and Urtica Extracts (WS® 1541) Exert Anti-proliferative and Anti-inﬂammatory Effects in a Mouse Model of Benign Prostate Hyperplasia. Front Pharmacol. 2019 Mar 29;10:311. DOI: 10.3389/fphar.2019.00311</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Dhouibi R, Aﬀes H, Ben Salem M, Hammami S, Sahnoun Z, Zeghal KM, Ksouda K. Screening of pharmacological uses of Urtica dioica and others beneﬁts. Prog Biophys Mol Biol. 2019 Jun 1. pii: S0079–6107 (19)30098–7. DOI: 10.1016/j.pbiomolbio.2019.05.008</mixed-citation><mixed-citation xml:lang="en">Dhouibi R, Aﬀes H, Ben Salem M, Hammami S, Sahnoun Z, Zeghal KM, Ksouda K. Screening of pharmacological uses of Urtica dioica and others beneﬁts. Prog Biophys Mol Biol. 2019 Jun 1. pii: S0079–6107 (19)30098–7. DOI: 10.1016/j.pbiomolbio.2019.05.008</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Cheetham PJ. Role of complimentary therapy for male LUTS. Curr Urol Rep. 2013 Dec;14 (6):606–13. DOI: 10.1007/s11934–013–0372–3</mixed-citation><mixed-citation xml:lang="en">Cheetham PJ. Role of complimentary therapy for male LUTS. Curr Urol Rep. 2013 Dec;14 (6):606–13. DOI: 10.1007/s11934–013–0372–3</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Powell SR. The antioxidant properties of zinc. J Nutr. 2000May;130(5S Suppl):1447S-54S. DOI: 10.1093/jn/130.5.1447S</mixed-citation><mixed-citation xml:lang="en">Powell SR. The antioxidant properties of zinc. J Nutr. 2000May;130(5S Suppl):1447S-54S. DOI: 10.1093/jn/130.5.1447S</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Costello LC, Franklin RB. A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancer. Arch Biochem Biophys. 2016 Dec 1;611:100–112. DOI: 10.1016/j.abb.2016.04.014</mixed-citation><mixed-citation xml:lang="en">Costello LC, Franklin RB. A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancer. Arch Biochem Biophys. 2016 Dec 1;611:100–112. DOI: 10.1016/j.abb.2016.04.014</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Flynn A, Hirvonen T, Mensink GB, Ocké MC, Serra-Majem L, Stos K, et al. Intake of selected nutrients from foods, from fortiﬁ-cation and from supplements in various European countries. Food Nutr Res. 2009 Nov 12;53. DOI: 10.3402/fnr.v53i0.2038</mixed-citation><mixed-citation xml:lang="en">Flynn A, Hirvonen T, Mensink GB, Ocké MC, Serra-Majem L, Stos K, et al. Intake of selected nutrients from foods, from fortiﬁ-cation and from supplements in various European countries. Food Nutr Res. 2009 Nov 12;53. DOI: 10.3402/fnr.v53i0.2038</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Cui D, Han G, Shang Y, Mu L, Long Q, Du Y. The eﬀect of chronic prostatitis on zinc concentration of prostatic ﬂuid and seminal plasma: a systematic review and meta-analysis. Curr Med Res Opin. 2015;31 (9):1763–9. DOI: 10.1185/03007995.2015.1072707</mixed-citation><mixed-citation xml:lang="en">Cui D, Han G, Shang Y, Mu L, Long Q, Du Y. The eﬀect of chronic prostatitis on zinc concentration of prostatic ﬂuid and seminal plasma: a systematic review and meta-analysis. Curr Med Res Opin. 2015;31 (9):1763–9. DOI: 10.1185/03007995.2015.1072707</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Goodarzi D, Cyrus A, Baghinia MR, Kazemifar AM, Shirincar M. The eﬃcacy of zinc for treatment of chronic prostatitis. Acta Med Indones. 2013 Oct;45 (4):259–64</mixed-citation><mixed-citation xml:lang="en">Goodarzi D, Cyrus A, Baghinia MR, Kazemifar AM, Shirincar M. The eﬃcacy of zinc for treatment of chronic prostatitis. Acta Med Indones. 2013 Oct;45 (4):259–64</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
