rpmjResearch'n Practical Medicine JournalResearch and Practical Medicine Journal2410-1893"QUASAR", LLC10.17709/2409-2231-2019-6-3-11rpmj-428Research ArticleКлиническое наблюдениеClinical Case ReportsОПТИМАЛЬНАЯ ЛЕЧЕБНАЯ СТРАТЕГИЯ ТЕРАПИИ БОЛЬНЫХ С ПРОГРЕССИРУЮЩИМ ПЛОСКОКЛЕТОЧНЫМ РАКОМ ОРГАНОВ ГОЛОВЫ И ШЕИOPTIMAL TREATMENT STRATEGY FOR PATIENTS WITH PROGRESSIVE SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECKhttps://orcid.org/0000-0003-4879-2687БолотинаЛ. В.BolotinaL. V.

д. м.н., руководитель отделения химиотерапии

MD, PhD, DSc, head of chemotherapy department

lbolotina@yandex.ruКравцовС. А.KravtsovC. A.

д. м.н., заведующий отделением хирургии опухолей головы и шеи

MD, PhD, DSc, head of the head and neck tumor surgery department

https://orcid.org/0000-0002-2061-0522УстиноваТ. В.UstinovaT. V.

врач-онколог отделения химиотерапии

oncologist, chemotherapy department

КарпенкоЕ. Ю.KarpenkoE. Yu.

младший научный сотрудник отделения химиотерапии

junior researcher, chemotherapy department

https://orcid.org/0000-0003-0092-0459КорниецкаяА. Л.KornietskayaA. L.

к. м.н., старший научный сотрудник отделения химиотерапии

MD, PhD, senior researcher, department of chemotherapy

ПайчадзеА. А.PaichadzeA. A.

к. м.н., научный сотрудник отделения химиотерапии

MD, PhD, researcher, department of chemotherapy

ГалкинВ. Н.GalkinV. N.

д. м.н., профессор, главный врач

MD, PhD, DSc, professor, head physician

https://orcid.org/0000-0001-8784-8415КапринА. Д.KaprinA. D.

академик РАН, д. м.н., профессор, заведующий кафедрой урологии и оперативной нефрологии с курсом онкоурологии Медицинского института РУДН, генеральный директор

Academician of RAS, PhD, MD, Prof.; Corr. member of the Russian Academy of Education; Honored Physician of the Russian Federation; General Director of National Medical Research Radiological Centre, Head of Department of Urology with Course of Urological Oncology, Faculty for Postgraduate Training, Peoples’ Friendship University of Russia

ФеденкоА. А.FedenkoA. A.

д. м.н., руководитель отдела лекарственного лечения опухолей

MD, PhD, DSc, head of tumor drug treatment department

Московский научно-исследовательский онкологический институт им. П.А.Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской ФедерацииРоссияP. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationRussian FederationГБУЗ «Городская клиническая онкологическая больница №1» Департамента здравоохранения г. МосквыРоссияCity Clinical Oncology Hospital No. 1, Moscow Department of HealthRussian Federation20190509201963115128Copyright © Болотина Л.В., Кравцов С.А., Устинова Т.В., Карпенко Е.Ю., Корниецкая А.Л., Пайчадзе А.А., Галкин В.Н., Каприн А.Д., Феденко А.А., 20192019Болотина Л.В., Кравцов С.А., Устинова Т.В., Карпенко Е.Ю., Корниецкая А.Л., Пайчадзе А.А., Галкин В.Н., Каприн А.Д., Феденко А.А.Bolotina L.V., Kravtsov C.A., Ustinova T.V., Karpenko E.Y., Kornietskaya A.L., Paichadze A.A., Galkin V.N., Kaprin A.D., Fedenko A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpmj.ru/rpmj/article/view/428

Лечение распространенных форм плоскоклеточного рака органов, локализующихся на голове и шее, не подлежащих хирургическому лечению, ограничено использованием химиолучевой терапии с платиновыми производными или лекарственной терапии платиносодержащими режимами. При прогрессии заболевания назначались малоэффективные цитостатики 2‑й линии, принципиально не меняющие течение опухолевого процесса. Внедрение в клиническую практику препаратов оригинального механизма действия позволило существенно увеличить эффективность лекарственной терапии при прогрессировании после платиносодержащей химиотерапии. В статье представлены два клинических наблюдения, демонстрирующих актуальность стратегии использования ингибиторов контрольных точек иммунного ответа после препаратов платины.

The treatment of common forms of squamous cell carcinoma of the organs located on the head and neck that are not subject to surgical treatment is limited to the use of chemoradiotherapy with platinum derivatives or drug therapy with platinum-containing regimens. With the progression of the disease, ineffective 2‑line cytostatics were prescribed that did not fundamentally change the course of the tumor process. The introduction into clinical practice of drugs of the original mechanism of action has significantly increased the effectiveness of drug therapy during progression after platinum-containing chemotherapy. The article presents two clinical observations that demonstrate the relevance of the strategy of using inhibitors of immune response control points after platinum preparations.

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The authors declare that there are no conflicts of interest present.