rpmjResearch'n Practical Medicine JournalResearch and Practical Medicine Journal2410-1893"QUASAR", LLC10.17709/2409-2231-2019-6-4-3rpmj-453Research ArticleОригинальные статьи. Онкология, лучевая терапияOriginal Articles. ОncologyВлияние некоторых клинико-морфологических факторов прогноза на 5-летнюю выживаемость пациенток с I стадией рака шейки маткиThe influence of some clinical and morphological prognosis factors on the 5-year survival of patients with stage I cervical cancerhttps://orcid.org/0000-0002-5796-3719МакароваЕ. В.MakarovaE. V.

Макарова Елена Викторовна - аспирант кафедры лучевой диагностики, лучевой терапии, онкологии ОрГМУ; врач отделения ультразвуковой диагностики ООКОД.

460000, Оренбург, ул. Советская, д. 6; 460021, Оренбург, пр-т Гагарина, д. 11.

Elena V. Makarova - graduate student of department of radiation diagnosis, radiotherapy, oncology Orenburg State Medical University of Ministry of Health of Russia; doctor in the department of ultrasound diagnostics Orenburg Regional Clinical Oncology Dispensary.

6 Sovetskaya str., Orenburg 460000; 11 Gagarin ave., Orenburg 460021.

malena2419@yandex.ruhttps://orcid.org/0000-0001-8371-740XСеньчуковаМ. А.SenchukovaM. A.

Сеньчукова Марина Алексеевна - доктор медицинских наук, профессор кафедры лучевой диагностики, лучевой терапии, онкологии ОрГМУ; врач отделения торакальной хирургии ООКОД.

460000, Оренбург, ул. Советская, д. 6; 460021, Оренбург, пр-т Гагарина, д. 11.

Marina A. Senchukova - MD, PhD, DSc, professor of the department of radiation diagnostics, radiation therapy, oncology Orenburg State medical university; doctor of the department of thoracic surgery Orenburg Regional Clinical Oncology Center.

6 Sovetskaya str., Orenburg 460000; 11 Gagarin ave., Orenburg 460021.

Оренбургский государственный медицинский университет Министерства здравоохранения Российской Федерации; Оренбургский областной клинический онкологический диспансерРоссияOrenburg State Medical University; Orenburg Regional Clinical Oncology CenterRussian Federation201925122019643444Copyright © Макарова Е.В., Сеньчукова М.А., 20192019Макарова Е.В., Сеньчукова М.А.Makarova E.V., Senchukova M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpmj.ru/rpmj/article/view/453Цель исследования

Цель исследования. Проанализировать отдаленные результатов лечения пациенток с I стадией рака шейки матки (РШМ) в зависимости от клинико-морфологических особенностей заболевания.

Пациенты и методы

Пациенты и методы. Проведен ретроспективный анализ отдаленных результатов лечения 75 пациенток c I стадией РШМ в возрасте от 21 до 76 лет, получивших на первом этапе хирургическое лечение в ГБУЗ «Оренбургский областной клинический онкологический диспансер» в период с 2008 по 2013 гг. Данные о пациентах получали из амбулаторных карт и канцер-регистра. Статистическую обработку полученных результатов выполняли с использованием программы Statistica 6.0.

Результаты

Результаты. Рецидив заболевания выявлен у 7 пациенток, и 7 пациенток умерли в различные сроки после окончания лечения. 5-летняя безрецидивная (БВ) и общая выживаемость (ОВ) составили 90,3%. При этом 5-летняя БВ составила: 95,2% и 66,0% при глубине инвазии до 10 мм и больше 10 мм (р=0,0004); 94,4% и 89,5% при IA и IB стадиях (р>0,4); 80,6% и 97,6% при наличии и отсутствии адъювантной лучевой терапии (p=0,002) соответственно. 5-летняя ОВ составила: 96,7% и 47,0% при глубине инвазии до 10 мм и больше 10 мм (p=0,00001); 97,0% и 84,2% при IA и 1В стадиях (p=0,07); 80,6% и 97,6% при наличии и отсутствии адъювантной лучевой терапии (p=0,02) соответственно. Отмечено, что у 11 пациенток с IB стадией, не получавших адъювантную лучевую терапию, не было рецидива, а у 6 пациенток с 1А-1В стадией, несмотря на проведенную лучевую терапию, отмечен рецидив РШМ.

Заключение

Заключение. Полученные результаты свидетельствуют о том, что использования только клинико-морфологических факторов недостаточно для точной оценки прогноза РШМ, и поиск новых маркеров оценки риска рецидива РШМ не утратил своей актуальности.

Purpose of the study

Purpose of the study. To analyze the treatment long-term results of patients with cervical cancer (CC) depending on the clinical and morphological characteristics of the disease.

Patients and methods

Patients and methods. 75 patients with stage I cervical cancer at the age of 21 to 76 years, were included in this retrospective study. All patients have been operated at the first stage of treatment in the Orenburg Regional Clinical Oncology Center from 2008 to 2013. Patient data was obtained from patient card and the "cancer-register". The statistical analis of the results was performed using the Statistica 6 software.

Results

Results. Recurrence of disease was detected in 7 patients and 7 patients died after treatment. 5-year relapse-free survival (RFS) and overall survival (OS) were 90,3%. 5-year RFS was: 95.2% and 66.0% — in depth of invasion of 10 mm or less and more than 10 mm (p=0.0004); 94.4% and 89.5% — in stages IA and IB (p>0.4) and 80.6% and 97.6% — in the presence and absence of adjuvant radiation therapy (p=0.002), respectively. 5-year OS was: 96.7% and 47.0% — in depth of invasion of 10 mm or less and more than 10 mm (p=0.00001); 97.0% and 84.2% — in stages IA and IB (p=0.07); 80.6% and 97.6% — in the presence and absence of adjuvant radiation therapy (p=0.02), respectively. There were no recurrence in 11 patients with IB stage, who did not receive adjuvant RT and, but ones were observed in 6 patients with stage IA — IB, who received the adjuvant RT.

Conclusion

Conclusion. These results indicate that the use of only clinical and morphological factors is not sufficient to accurately assess of the CC prognosis and the search for new markers of the CC recurrence risk has not lost its relevance.

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The authors declare that there are no conflicts of interest present.