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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rpmj</journal-id><journal-title-group><journal-title xml:lang="ru">Research'n Practical Medicine Journal</journal-title><trans-title-group xml:lang="en"><trans-title>Research and Practical Medicine Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="epub">2410-1893</issn><publisher><publisher-name>"QUASAR", LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17709/2409-2231-2020-7-3-9</article-id><article-id custom-type="elpub" pub-id-type="custom">rpmj-592</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клинические наблюдения</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Clinical Case Reports</subject></subj-group></article-categories><title-group><article-title>Хирургическое лечение пациента с почечно-клеточным раком, осложненным специфическим (опухолевым) и неспецифическим тромбозом нижней полой вены</article-title><trans-title-group xml:lang="en"><trans-title>Surgical treatment of patients with renal cell cancer complicated by specific (tumor) and non-specific thrombosis of the inferior Vena cava</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5597-9533</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воробьев</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vorobev</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Воробьев Николай Владимирович – к.м.н., заведующий отделением онкоурологии; врач-уролог, доцент кафедры онкологии, радиотерапии и пластической хирургии  </p><p>125284, г. Москва, 2-й Боткинский проезд, д. 3</p><p>119991, г. Москва, ул. Трубецкая, д. 8, стр. 2</p><p>SPIN: 3426-9843</p><p>AuthorID: 195018</p></bio><bio xml:lang="en"><p>Nikolay V. Vorobyev – Cand. Sci. (Med.), head of the department of oncourology; Urologist, associate professor of the department of Oncology, radiotherapy and plastic surgery </p><p>3 2nd Botkinskiy travel, Moscow 125284</p><p>8/2 Trubetskaya str., Moscow 119991</p><p>SPIN: 3426-9843</p><p>AuthorID: 195018 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1152-0058</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ашырова</surname><given-names>Ф. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Ashyrova</surname><given-names>F. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ашырова Фидан Самировна – врач-онколог отделения онкоурологии</p><p>125284, г. Москва, 2-й Боткинский проезд, д. 3</p><p>SPIN: 5601-7310</p><p>AuthorID: 1070852</p></bio><bio xml:lang="en"><p>Fidan S. Ashyrova – the doctor-oncologist of the department of oncourology </p><p>3 2nd Botkinskiy travel, Moscow 125284</p><p>SPIN: 5601-7310</p><p>AuthorID: 1070852 </p></bio><email xlink:type="simple">fidan_samirovna@bk.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7719-9976</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Головащенко</surname><given-names>М. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Golovashchenko</surname><given-names>M. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Головащенко Максим Петрович – к.м.н., врач-онколог, научный сотрудник отделения онкоурологии</p><p>125284, г. Москва, 2-й Боткинский проезд, д. 3</p><p>SPIN: 8082-1075</p><p>AuthorID: 714890</p></bio><bio xml:lang="en"><p>Maksim P. Golovashchenko – Cand. Sci. (Med.), oncologist, researcher at the department of oncourology </p><p>3 2nd Botkinskiy travel, Moscow 125284</p><p>SPIN: 8082-1075</p><p>AuthorID: 714890 </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петров</surname><given-names>Л. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrov</surname><given-names>L. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петров Леонид Олегович – к.м.н., заведующий отделением лучевого и хирургического лечения заболеваний абдоминальной области </p><p>125284, г. Москва, 2-й Боткинский проезд, д. 3</p><p>249035, г. Обнинск, ул. Королева, д. 4</p><p>SPIN: 4559-3613</p><p>AuthorID: 665865</p></bio><bio xml:lang="en"><p>Leonid O. Petrov – Cand. Sci. (Med.), head of the department of radiation and surgical treatment of abdominal diseases </p><p>3 2nd Botkinskiy travel, Moscow 125284</p><p>4 Korolev str., Obninsk 249036</p><p>SPIN: 4559-3613</p><p>AuthorID: 665865 </p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8784-8415</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каприн</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Kaprin</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каприн Андрей Дмитриевич – академик РАН, д.м.н., генеральный директор; заведующий кафедрой урологии с курсом онкоурологии </p><p>125284, г. Москва, 2-й Боткинский проезд, д. 3</p><p>117198, г. Москва, ул. Миклухо-Маклая, д. 6</p><p>SPIN: 1759-8101</p><p>AuthorID: 96775</p><p>ResearcherID: K-1445-2014</p><p>Scopus Author ID: 6602709853</p></bio><bio xml:lang="en"><p>Andrey D. Kaprin – academician of the Russian Academy of Sciences, Dr. Sci. (Med.), general Director; Head of the department of urology with the course of oncourology </p><p>3 2nd Botkinskiy travel, Moscow 125284</p><p>6 Miklukho-Maklaya str., Moscow 117198</p><p>SPIN: 1759-8101</p><p>AuthorID: 96775</p><p>ResearcherID: K-1445-2014</p><p>Scopus Author ID: 6602709853 </p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>МНИОИ им. П.А.Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М.Сеченова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>P.A.Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre; I.M.Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>МНИОИ им. П.А.Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>P.A.Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>МНИОИ им. П.А.Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации; МРНЦ им. А.Ф.Цыба – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>P.A.Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre; A.F.Tsyb Medical Radiological Research Center – Branch of the National Medical Research Radiological Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>МНИОИ им. П.А.Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации; ФГАОУ ВО «Российский университет дружбы народов»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>P.A.Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre; Peoples Friendship University of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>12</day><month>09</month><year>2020</year></pub-date><volume>7</volume><issue>3</issue><fpage>91</fpage><lpage>98</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Воробьев Н.В., Ашырова Ф.С., Головащенко М.П., Петров Л.О., Каприн А.Д., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Воробьев Н.В., Ашырова Ф.С., Головащенко М.П., Петров Л.О., Каприн А.Д.</copyright-holder><copyright-holder xml:lang="en">Vorobev N.V., Ashyrova F.S., Golovashchenko M.P., Petrov L.O., Kaprin A.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpmj.ru/rpmj/article/view/592">https://www.rpmj.ru/rpmj/article/view/592</self-uri><abstract><p>Среди злокачественных новообразований рак почки занимает одно из первых мест по темпам роста заболеваемости в России. Несмотря на возможности современных диагностических методов исследования, число пациентов с распространенными формами заболевания не снижается. В 5–10% случаев почечно-клеточный рак осложняется формированием опухолевого тромба в нижней полой вене (НПВ), что требует проведения хирургического вмешательства в объеме нефрэктомии с тромбэктомией, являющейся единственным эффективным вариантом лечения данной группы пациентов. Ранее результаты лечения местно-распространенного рака почки были неудовлетворительными в связи с высокой частотой развития осложнений и летальности после расширенных хирургических вмешательств. Тем не менее, совершенствование техники операции требует переоценки предыдущих представлений. Выполнение нефрэктомии с тромбэктомией из НПВ представляет собой непростую задачу и зачастую сопряжено не только с техническими трудностями, ввиду необходимости мобилизации, контроля и резекции нижней полой вены, но и с риском развития интра- и послеоперационных осложнений. Наиболее сложной задачей является выбор хирургической тактики при нисходящем неопухолевом геморрагическом тромбозе. В результате длительной опухолевой обструкции организовавшиеся кровяные сгустки, спаянные с интимой сосуда, нередко распространяются в общие подвздошные вены и, как правило, являются технически неудалимыми. При сохранении НПВ остаточный геморрагический тромб в области ее конфлюенса является потенциальным источником тромбоэмболии легочной артерии (ТЭЛА), для профилактики которой применяют механическую пликацию. Данный маневр не приводит к развитию клинически значимой хронической венозной недостаточности нижних конечностей (ХВН НК), послеоперационному тромбозу НПВ или ТЭЛА. Несмотря на техническую сложность операции и тяжелое течение послеоперационного периода, хирургическое лечение почечно-клеточного рака, осложненного опухолевым тромбозом, безусловно, оправдано. В данной статье представлен клинический случай хирургического лечения пациента с почечно-клеточным раком, осложненным массивным специфическим (опухолевым) и неспецифическим тромбозом при наличии сниженной паренхиматозно-выделительной функции контралатеральной почки и выраженной кардиальной патологии. Цель: поделиться опытом и продемонстрировать результаты успешного хирургического лечения почечноклеточного рака.</p></abstract><trans-abstract xml:lang="en"><p>Among malignant neoplasms, kidney cancer occupies one of the first places in terms of the growth rate of incidence in Russia. Despite the possibilities of modern diagnostic research methods, the number of patients with common forms of the disease does not decrease. In 5–10% of cases, renal cell carcinoma is complicated by the formation of a tumor clot in the inferior Vena cava (VCI), which requires volume surgery — nephrectomy with thrombectomy, which is the only effective treatment option for this group of patients. Previously, the results of treatment of locally advanced kidney cancer were unsatisfactory due to the high incidence of complications and mortality after extended surgical interventions. However, improving the operation technique requires a re-evaluation of previous representations. Performing a nephrectomy with a VCI thrombectomy is not an easy task and is often associated not only with technical difficulties due to the need for mobilization, control and resection of the inferior Vena cava, but also with the risk of intra — and postoperative complications. The most difficult task is the choice of surgical tactics for descending non-tumor hemorrhagic thrombosis. As a result of long-term tumor obstruction, organized blood clots that are soldered to the intima of the vessel often spread to the common iliac veins and, as a rule, are technically impossible to remove. If the VCI is preserved, a residual hemorrhagic blood clot in the area of its confluence is a potential source of pulmonary embolism (PE), for the prevention of which mechanical plication is used. This maneuver does not lead to the development of clinically significant chronic venous insufficiency of the lower extremities (CVI NC), postoperative VCI or PE thrombosis. Despite the technical complexity of the operation and the difficult course of the postoperative period, surgical treatment of renal cell cancer complicated by tumor thrombosis is certainly justified. This article presents a clinical case of surgical treatment of a patient with renal cell cancer complicated by massive specific (tumor) and non-specific thrombosis in the presence of reduced parenchymalexcretory function of the contralateral kidney and severe cardiac pathology. Goal: to share experience and demonstrate the results of successful surgical treatment of renal cell carcinoma.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>почечно-клеточный рак</kwd><kwd>радикальная нефрэктомия</kwd><kwd>тромбэктомия</kwd><kwd>нижняя полая вена</kwd><kwd>подвздошная вена</kwd><kwd>тромбоз</kwd><kwd>клинический случай</kwd></kwd-group><kwd-group xml:lang="en"><kwd>kidney cell cancer</kwd><kwd>radical nephrectomy</kwd><kwd>thrombectomy</kwd><kwd>inferior vena cava</kwd><kwd>iliac vein</kwd><kwd>thrombosis</kwd><kwd>clinical case</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Давыдов М.И., Матвеев В.Б., Матвеев Б.П., Фигурин К.М., Буйденок П.И. Феоктистов Ю.М. Операции на нижней полой вене у больных раком почки. VI Российская онкологическая конференция. Материалы конгрессов и конференций, М., 2002:108–109. 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