References

rpmj

Research'n Practical Medicine Journal

Research and Practical Medicine Journal

2410-1893

"QUASAR", LLC

10.17709/2409-2231-2020-7-4-10

rpmj-637

Research Article

Обзоры

Review

Возможности химиотерапии у больных местно-распространенным и метастатическим аденогенным раком поджелудочной железы

Possibilities of palliative chemotherapy in patients with locally advanced and metastatic pancreatic cancer

https://orcid.org/0000-0002-5750-8492

Москвичева

Л. И.

Moskvicheva

L. I.

Москвичева Людмила Ивановна – врач-онколог кабинета ультразвуковой диагностики и терапии

125284, г. Москва, 2-й Боткинский проезд, д. 3

SPIN: 8321-3464

AuthorID: 861695

Liudmila I. Moskvicheva – oncologist of the ultrasound department

3 2nd Botkinskiy travel, Moscow 125284

SPIN: 8321-3464

AuthorID: 861695

ludamed16@mail.ru

https://orcid.org/0000-0003-4879-2687

Болотина

Л. В.

Bolotina

L. V.

Болотина Лариса Владимировна - д.м.н., заведующая отделением химиотерапии

125284, г. Москва, 2-й Боткинский проезд, д. 3

SPIN: 2787-5414

AuthorID: 594953

Larisa V. Bolotina – Dr. Sci. (Med.), head of chemotherapy department

3 2nd Botkinskiy travel, Moscow 125284

SPIN: 2787-5414

AuthorID: 594953

МНИОИ им. П.А.Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской ФедерацииРоссияP.A.Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological CentreRussian Federation

2020

22122020

74118134

2020

Москвичева Л.И., Болотина Л.В.

Moskvicheva L.I., Bolotina L.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.rpmj.ru/rpmj/article/view/637

В настоящее время рак поджелудочной железы остается одной из наиболее неблагоприятных опухолевых патологий, характеризующейся выраженными сложностями диагностики и лечения, значительным влиянием на трудоспособность и качество жизни больных, низкими показателями продолжительности жизни пациентов. Особенности развития злокачественных новообразований данной локализации способствуют ограничению возможности выполнения радикального оперативного вмешательства, в связи с чем особая роль в лечении больных раком поджелудочной железы отводится химиотерапии. Специфическая системная лекарственная терапия при данной патологии является важнейшим и, в преобладающем числе случаев, обязательным элементом лечения. Она может осуществляться в неоадъювантном, адъювантном и самостоятельном режиме, включать моно- или поликомпонентные схемы, а также сочетаться с другими видами системного или локального противоопухолевого воздействия. Выбор режима химиотерапии зависит в первую очередь от общего соматического статуса пациента и определяется потенциальной токсичностью той или иной комбинации цитостатиков. В данном обзоре литературы продемонстрирована эффективность применения различных схем химиотерапии у больных раком поджелудочной железы III–IV стадии в рамках первой и второй линии, описаны частота возникновения нежелательных реакций на лечение и их характер, упомянуты пути снижения степени токсичности поликомпонентных режимов лекарственной терапии. Данный обзор выполнен на основании анализа научных источников интернет-ресурса «National Center for Biotechnological Information».

Currently, pancreatic cancer remains one of the most unfavorable tumor pathologies, characterized by pronounced difficulties in diagnostics and treatment, a significant impact on the ability to work and quality of life of patients, and low indicators of patient life expectancy. Features of the development of malignant neoplasms of this localization contribute to limiting the possibility of performing radical surgery, and therefore a special role in the treatment of patients with pancreatic cancer is assigned to chemotherapy. Specific systemic drug therapy for this pathology is the most important and, in the majority of cases, mandatory element of treatment. It can be carried out in a neoadjuvant, adjuvant and independent mode, include mono- or multi- component schemes, and be combined with other types of systemic or local antitumor effects. The choice of chemotherapy regimen depends primarily on the General somatic status of the patient and is determined by the potential toxicity of a particular combination of cytostatics. This review of the literature demonstrates the effectiveness of various chemotherapy regimens in patients with stage III–IV pancreatic cancer in the first and second lines, describes the frequency of adverse reactions to treatment and their nature, and mentions ways to reduce the toxicity of multicomponent drug therapy regimens. This review is based on the analysis of scientific sources of the Internet resource "National Center for Biotechnological Information".

местно-распространенный и метастатический рак поджелудочной железыпротоковая аденокарциномапаллиативная онкологическая помощьхимиотерапиялекарственная терапияонкология

locally advanced and metastatic pancreatic canceradenocarcinomapalliative cancer carechemotherapydrug therapyoncology

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The authors declare that there are no conflicts of interest present.