rpmjResearch'n Practical Medicine JournalResearch and Practical Medicine Journal2410-1893"QUASAR", LLC10.17709/2410-1893-2021-8-3-11rpmj-683Research ArticleОбзорыReviewО механизмах противоопухолевого действия соединений трополонового рядаOn mechanisms of antitumor action of tropolon series compoundshttps://orcid.org/0000-0001-8832-8219ЖуковаГ. В.ZhukovaG. V.

Жукова Галина Витальевна – д.б.н., старший научный сотрудник испытательного лабораторного центра, SPIN: 1887-7415, AuthorID: 564827, Researcher ID: Y-4243-2016,Scopus Author ID: 7005456284

344037, г. Ростов-на-Дону, ул. 14-я линия, д. 63

Galina V. Zhukova – Dr. Sci. (Biol.), senior researcher at the testing laboratory center, SPIN: 1887-7415, AuthorID: 564827, Researcher ID: Y-4243-2016, Scopus Author ID: 7005456284

63 14 line str., Rostov-on-Don 344037

galya_57@mail.ruhttps://orcid.org/0000-0002-3036-6199ЛукбановаЕ. А.LukbanovaE. A.

Лукбанова Екатерина Алексеевна – научный сотрудник испытательного лабораторного центра, SPIN: 4078-4200, AuthorID: 837861, Scopus Author ID: 57215860146

344037, г. Ростов-на-Дону, ул. 14-я линия, д. 63

Ekaterina A. Lukbanova – researcher at the testing laboratory center, SPIN: 4078-4200, AuthorID: 837861, Scopus Author ID: 57215860146

63 14 line str., Rostov-on-Don 344037

katya.samarskaja@yandex.ruhttps://orcid.org/0000-0001-6364-1794ПротасоваТ. П.ProtasovaT. P.

Протасова Татьяна Пантелеевна – к.б.н., научный сотрудник испытательного лабораторного центра, SPIN: 4542-3588, AuthorID: 760427

344037, г. Ростов-на-Дону, ул. 14-я линия, д. 63

Tatyana P. Protasova – Cand. Sci. (Biol.), researcher at the testing laboratory center, SPIN: 4542-3588, AuthorID: 760427

63 14 line str., Rostov-on-Don 344037

protasovatp@yandex.ruhttps://orcid.org/0000-0003-0088-2990ЗаикинаЕ. В.ZaikinaE. V.

Заикина Екатерина Владиславовна – младший научный сотрудник испытательного лабораторного центра, SPIN: 4000-4369, AuthorID: 1045258

344037, г. Ростов-на-Дону, ул. 14-я линия, д. 63

Ekaterina V. Zaikina – junior researcher at the testing laboratory center, SPIN: 4000-4369, AuthorID: 1045258

63 14 line str., Rostov-on-Don 344037

katherine_bio@mail.ruhttps://orcid.org/0000-0002-9337-5535КиблицкаяА. А.KiblitskayaA. A.

Киблицкая Александра Андреевна – научный сотрудник испытательного лабораторного центра 

344037, г. Ростов-на-Дону, ул. 14-я линия, д. 63

Aleksandra A. Kiblitskaya – researcher at the testing laboratory center 

63 14 line str., Rostov-on-Don 344037

kibaleand@gmail.comФГБУ «НМИЦ онкологии» Минздрава РоссииРоссияNational Medical Research Centre for Oncology of the Ministry of Health of RussiaRussian Federation20212309202183118132Copyright © Жукова Г.В., Лукбанова Е.А., Протасова Т.П., Заикина Е.В., Киблицкая А.А., 20212021Жукова Г.В., Лукбанова Е.А., Протасова Т.П., Заикина Е.В., Киблицкая А.А.Zhukova G.V., Lukbanova E.A., Protasova T.P., Zaikina E.V., Kiblitskaya A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpmj.ru/rpmj/article/view/683

В обзоре приведены сведения о механизмах противоопухолевого действия природных и синтетических соединений трополонового ряда, полученные в течение последних 30 лет в исследованиях на культурах клеток и, в меньшей степени, в экспериментах in vivo. Интерес к данной группе веществ обусловлен острой потребностью клинической онкологии в средствах, эффективно повреждающих злокачественные клетки и, одновременно, безопасных для здоровых тканей. Наиболее полно изучены процессы, реализующие эффекты колхицина, хинокитиола (ß-туйяплицина) и некоторых их дериватов (производные бистрополона, α-замещенные трополоны и др). При этом были выявлены более многочисленные механизмы реализации противоопухолевого действия хинокитиола и его производных по сравнению с колхицином. Помимо нарушения формирования веретена деления, показанного для колхицина и колхамина, описаны такие явления, как каспазо-зависимый апоптоз и некоторые другие виды апоптоза, аутофагия, ограничение митохондриального метаболизма, повреждение и деметилирование ДНК, ускоренное старение малигнизированных клеток и проч. Показана перспективность использовавния производных 2‑хинолил 1,3‑трополона и связь их противоопухолевого действия с индукцией апоптоза и изменением активности сигнального пути ERK в некоторых типах малигнизированных клеток. Полученные результаты свидетельствуют о многообразии возможных путей влияния трополонов на состояние злокачественных клеток, условия реализации каждого из которых нуждаются в уточнении, особенно при дефиците сведений о процессах in vivo.

В обзоре использованы сведения литературы, представленной в базах данных Scopus, WoS, Pubmed. 35 % работ опубликовано за последние 5 лет.

The review provides information on the mechanisms of the antitumor action of natural and synthetic compounds of the tropolone series, obtained over the past 30 years in studies on cell cultures and, to a lesser extent, in in vivo experiments. Interest in this group of substances is due to the urgent need of clinical oncology for drugs that effectively damage malignant cells and, at the same time, are safe for healthy tissues. The processes that realize the effects of colchicine, hinokithiol (ß-tuyaplicin) and some of their derivatives (derivatives of bistropolone, α-substituted tropolones, etc.) have been studied most fully. Herewith, more numerous mechanisms of realization of the antitumor effect of hinokithiol and its derivatives were revealed in comparison with colchicine. In addition to the disruption in the formation of the cell division spindle, shown for colchicine and colchamine, such phenomena as caspase-dependent apoptosis and some other types of apoptosis, autophagy, limitation of mitochondrial metabolism, DNA damage and demethylation, and accelerated aging of malignant cells etc. have been described. The promising properties of 2‑quinolyl 1,3‑tropolone derivatives have been shown, and the relationship of their antitumor effect with the induction of apoptosis and changes in the activity of the ERK signaling pathway in some types of malignant cells have been revealed. The results indicate a multiplicity of possible ways of the influence of tropolones on the state of malignant cells, the conditions for the implementation of ones need to be clarified, especially with a lack of information about in vivo processes.

The review includes information from the literature presented in the Scopus, WoS, Pubmed databases. 35 % of articles have been published in the last 5 years.

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The authors declare that there are no conflicts of interest present.