rpmjResearch'n Practical Medicine JournalResearch and Practical Medicine Journal2410-1893"QUASAR", LLC10.17709/2410-1893-2022-9-3-9rpmj-774Research ArticleОбзорReviewЭволюция персонализированной медицины: обзор литературыThe evolution of personalized medicine: literature reviewhttps://orcid.org/0000-0001-9777-1220ДолгополовИ. С.DolgopolovI. S.

д.м.н., заведующий кафедрой педиатрии, 

170100, г. Тверь, ул. Советская, д. 4

Dr. Sci. (Med.), head of the department of pediatrics, pediatric faculty, head of the pediatric medical center,

12/1 Vorontsovo Pole str., Moscow 105064

irdolg@rambler.ruhttps://orcid.org/0000-0002-8398-7001РыковМ. Ю.RykovM. Yu.

д.м.н., доцент, заведующий кафедрой онкологии факультета дополнительного профессионального образования, советник при ректорате по научной работе, 170100, г. Тверь, ул. Советская, д. 4;

105064, г. Москва, ул. Воронцово Поле, д. 12, стр. 1

Dr. Sci. (Med.), associate professor, head of the department of Oncology of the Faculty of Additional Professional Education, Advisor to the Rector for Scientific Work, 12/1 Vorontsovo Pole str., Moscow 105064;

researcher, Moscow

wordex2006@rambler.ruТверской ГМУ Минздрава РоссииРоссияTver State Medical UniversityRussian FederationТверской ГМУ Минздрава России; Национальный НИИ общественного здоровья им. Н. А. СемашкоРоссияTver State Medical University; N. A. Semashko National Research Institute of Public HealthRussian Federation20221708202293117128Copyright © Долгополов И.С., Рыков М.Ю., 20222022Долгополов И.С., Рыков М.Ю.Dolgopolov I.S., Rykov M.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpmj.ru/rpmj/article/view/774

«Персонализированная» медицина основана на утверждении, что каждый человек обладает уникальными характеристиками на молекулярном, физиологическом, экологическом и поведенческом уровнях, и, в случае развития болезни, ее лечение следует проводить с учетом этих уникальных характеристик. Это убеждение было в некоторой степени подтверждено применением новейших технологий, таких как секвенирование ДНК, протеомика, протоколы визуализации и использования беспроводных устройств для мониторинга состояния здоровья, которые выявили межиндивидуальные различия в уровнях экспрессии и пенетрантности генов. Проведен поиск литературных источников (научных статей), включая опубликованные в рецензируемых журналах, индексируемых в pubmed, Wos, scopus и РИНЦ с 2010 по 2021 гг. В обзор включено 49 статей, посвященных персонализированной медицине. Рассматриваются технологии, которые делают возможной персонализированную медицину, новый опыт, способы проверки и перспективы применения индивидуально подобранных лекарственных препаратов, а также потенциальные подходы к лечению людей с проблемами фертильности и бесплодием. Можно предположить, что индивидуализация медицинской практики будет развиваться, особенно в случае редких генетических заболеваний. Тем более, что индивидуальный подход к пациенту является более эффективным и рентабельным.

"Personalized" medicine is based on the belief that each person has unique molecular, physiological, environmental and behavioral characteristics and in case of disease development each patient should be treated taking into account these unique characteristics. This belief was to somehow confirmed by the use of the latest technologies, such as DNA sequencing, proteomics, imaging protocols and the use of wireless devices for health monitoring, which revealed inter-individual differences in gene expression and penetrance levels. A search was conducted for literary sources (scientific articles), including those published in peer-reviewed journals indexed in Pubmed, WOS, Scopus and RSCI from 2010 to 2021. The review includes 49 articles on personalized medicine. The technologies that make personalized medicine possible, new experience, methods of testing and prospects for the use of individually selected medicinal preparations, as well as potential approaches to the treatment of people with fertility problems and infertility are considered. It can be assumed that the individualization of medical practice will develop, especially in the case of rare genetic diseases. Moreover, an individual approach to the patient is more effective and rentable.

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The authors declare that there are no conflicts of interest present.