rpmjResearch'n Practical Medicine JournalResearch and Practical Medicine Journal2410-1893"QUASAR", LLC10.17709/2410-1893-2022-9-2-13rpmj-813Research ArticleОбзорыReviewАндрогены и тяжесть течения новой коронавирусной инфекцииAndrogens and severity of the new coronavirus infection coursehttps://orcid.org/0000-0002-5160-925XГрицкевичА. А.GritskevichA. A.

Грицкевич Александр Анатольевич – д.м.н., заведующий отделением урологии; профессор кафедры урологии и оперативной нефрологии с курсом онкоурологии. SPIN: 2128-7536, AuthorID: 816947, Scopus Author ID: 57194755867

г. Москва

Alexander A. Gritskevich – Dr. Sci. (Med.), head of the department of urology; Professor at the Department of Urology and Operative Nephrology with a course of Oncourology. SPIN: 2128-7536, AuthorID: 816947, Scopus Author ID: 57194755867

Moscow

grekaa@mail.ruhttps://orcid.org/0000-0003-1113-6811ПрохороваЯ. Д.ProkhorovaYa. D.

Прохорова Яна Дмитриевна – ординатор кафедры эндокринологии лечебного факультета

г. Москва

Yana D. Prokhorova – resident at the department of endocrinology of the medical faculty

Moscow

prokhorova_yana.96@mail.ruhttps://orcid.org/0000-0002-3646-1664БайтманТ. П.BaitmanT. P.

Байтман Татьяна Павловна – аспирант. SPIN: 4684-3230, AuthorID: 1064032, Scopus Author ID: 57219438104

115093, г. Москва, ул. Большая Серпуховская, д. 27

Tatiana P. Baitman – PhD student. SPIN: 4684-3230, AuthorID: 1064032, Scopus Author ID: 57219438104

27 Bolshaya Serpukhovskaya str., Moscow 115093

bit.t@mail.ruhttps://orcid.org/0000-0002-0086-869XГрицкевичЕ. Ю.GritskevichE. Yu.

Грицкевич Елена Юрьевна – к.м.н., ассистент кафедры эндокринологии лечебного факультета. SPIN: 4125-2055, AuthorID: 1042992

г. Москва

Elena Yu. Gritskevich – Cand. Sci. (Med.), assistant of the department of endocrinology of the medical faculty. SPIN: 4125-2055, AuthorID: 1042992

Moscow

genyan.7@mail.ruhttps://orcid.org/0000-0002-0792-6012КостинА. А.KostinA. A.

Костин Андрей Александрович – чл.-корр. РАН, д.м.н., профессор, проректор по научной работе, заведующий кафедрой урологии с курсами онкоурологии, радиологии и андрологии факультета непрерывного медицинского образования; первый заместитель генерального директора. SPIN: 8073-0899, AuthorID: 193454, Scopus Author ID: 16175361500

г. Москваг. Обнинск

Andrew A. Kostin – Corresponding Member of RAS, Dr. Sci. (Med.), professor, vice-rector for research, head of the department of urology with courses in oncology, radiology and andrology of the faculty of continuing medical education; first deputy general director. SPIN: 8073-0899, AuthorID: 193454, Scopus Author ID: 16175361500

MoscowObninsk

andocrey@mail.ruНМИЦ хирургии им. А. В. Вишневского; Российский университет дружбы народовРоссияA. V. Vishnevsky National Medical Research Center of Surgery; Peoples Friendship University of RussiaRussian FederationРНИМУ им. Н. И. ПироговаРоссияN. I. Pirogov Russian National Research Medical UniversityRussian FederationНМИЦ хирургии им. А. В. ВишневскогоРоссияA. V. Vishnevsky National Medical Research Center of SurgeryRussian FederationРоссийский университет дружбы народов; НМИЦ радиологииРоссияPeoples Friendship University of Russia; National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationRussian Federation20220405202292143155Copyright © Грицкевич А.А., Прохорова Я.Д., Байтман Т.П., Грицкевич Е.Ю., Костин А.А., 20222022Грицкевич А.А., Прохорова Я.Д., Байтман Т.П., Грицкевич Е.Ю., Костин А.А.Gritskevich A.A., Prokhorova Y.D., Baitman T.P., Gritskevich E.Y., Kostin A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpmj.ru/rpmj/article/view/813

Анализ результатов работы в условиях пандемии новой коронавирусной инфекции показал, что пациенты со злокачественными новообразованиями (ЗНО) относятся к группе высокого риска заражения и тяжелого течения этого инфекционного заболевания. Частота развития осложнений COVID‑19 у рассматриваемой группы больных в 3,5 раза выше, чем в общей популяции, что во многом обусловлено иммунносупрессивным действием как самих онкологических заболеваний, так и их лечения.

Было предпринято немало попыток выделить и валидизировать прочие факторы риска тяжелого течения COVID‑19. Эпидемиологические данные свидетельствуют о том, что пожилые пациенты с хроническими заболеваниями, включая сахарный диабет (СД), артериальную гипертензию (АГ), ожирение, подвержены более тяжелому течению COVID‑19 с большей частотой летальных исходов. В ряде исследований отмечена большая частота встречаемости тяжелых форм инфекционного процесса и более высокий уровень COVID‑19‑ассоциированной летальности у мужчин. В настоящее время выявляются новые аспекты влияния гормональных изменений, в том числе ятрогенных, на течение коронавирусной инфекции. В частности, данные клинических исследований демонстрируют корреляцию между уровнем тестостерона в сыворотке крови и уровнем воспалительных цитокинов, особенностями проникновения вируса в клетки, течением заболевания в целом. Это особенно значимо для понимания особенностей новой коронавирусной инфекции у больных раком предстательной железы (РПЖ), в том числе для разработки лечебного алгоритма, показаний и противопоказаний к определенным методам лечения РПЖ в условиях пандемии, а также способов дополнительного терапевтического воздействия при сочетании РПЖ и COVID‑19.

В обзоре приведены результаты исследований, посвященных потенциальным механизмам повышенной восприимчивости мужчин к SARS‑CoV‑2 и обсуждаются вопросы поиска новых терапевтических мишеней при COVID‑19, рассмотрены особенности течения COVID‑19 у больных РПЖ в зависимости от уровня андрогенов, в том числе при андрогендепривационной терапии (АДТ).

The analysis results of work in the conditions of a pandemic of a new coronavirus infection pandemic showed that patients with malignant neoplasms (ZNO) belong to a group of high risk of infection and severe course of this infectious disease. The incidence of COVID‑19 complications in this group of patients is 3.5 times higher than in the general population, which is largely due to the immunosuppressive effect of both oncological diseases themselves and their treatment.

Many attempts have been held to identify and validate other risk factors for severe COVID‑19. Epidemiological data indicate that elderly patients with chronic diseases, including diabetes mellitus (DM), arterial hypertension (AH), obesity, are susceptible to a more severe course of COVID‑19 with a higher frequency of deaths. A number of studies have noted a higher incidence of severe forms of the infectious process and a higher level of COVID‑19‑associated mortality in men. Currently new aspects of the influence of hormonal changes, including iatrogenic ones, on the course of coronavirus infection are being identified. In particular, the data of clinical studies demonstrate a correlation between the level of testosterone in the blood serum and the level of inflammatory cytokines, the features of viral entry into cells, the course of the disease as a whole. This is especially important for understanding the features of the new coronavirus infection in patients with prostate cancer (PC), including for the development of a therapeutic algorithm, indications and contraindications to certain methods of treating PC in a pandemic, as well as ways of additional therapeutic effects when combined with PC and COVID‑19.

The review presents the results of studies on the potential mechanisms of increased susceptibility of men to SARS‑CoV‑2 and discusses the search for new therapeutic targets in COVID‑19, discusses the features of the course of COVID‑19 in patients with PC depending on the level of androgens, including androgen deprivation therapy (ADT).

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The authors declare that there are no conflicts of interest present.