rpmjResearch'n Practical Medicine JournalResearch and Practical Medicine Journal2410-1893"QUASAR", LLC10.17709/2409-2231-2015-2-4-10-16rpmj-96Research ArticleОригинальные статьи. Онкология, лучевая терапияOriginal Articles. ОncologyПРИМЕНЕНИЕ «ОКТРЕОТИДА-ДЕПО» ДЛЯ ПРОФИЛАКТИКИ ПОСЛЕОПЕРАЦИОННОГО ПАНКРЕАТИТА ПОСЛЕ РАСШИРЕННЫХ ОПЕРАЦИЙ ПО ПОВОДУ ЗЛОКАЧЕСТВЕННЫХ ОПУХОЛЕЙ ЖЕЛУДКА, ПИЩЕВОДА И КАРДИИTHE USAGE OF "OCTREOTIDE-DEPOT" FOR THE PREVENTION OF POSTOPERATIVE PANCREATITIS AFTER EXTENDED SURGERY OF MALIGNANT TUMORS OF THE STOMACH, ESOPHAGUS AND THE CARDIAХомяковВ. М.KhomyakovV. M.

к.м.н., руководитель торакоабдоминального отделения отдела торакоабдоминальной онкохирургии МНИОИ им. П. А. Герцена — филиала ФГБУ «НМИРЦ» Минздрава России

PhD, head of thoracoabdominal department, thoracoabdominal division P. A. Hertsen Moscow Oncology Research Institute — branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation 

ИвановА. В.IvanovA. V.

аспирант торакоабдоминального отделения отдела торакоабдоминальной онкохирургии МНИОИ им. П. А. Герцена — филиала ФГБУ «НМИРЦ» Минздрава России

postgraduate of thoracoabdominal department, thoracoabdominal division P. A. Hertsen Moscow Oncology Research Institute — branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation 

МНИОИ им. П.А. Герцена - филиал ФГБУ "НМИРЦ" Минздрава России (Москва, Россия), 125284, Россия, Москва, 2-й Боткинский проезд, 3РоссияP. A. Hertsen Moscow Oncology Research Institute — branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian FederationRussian Federation201531122015241016Copyright © Хомяков В.М., Иванов А.В., 20162016Хомяков В.М., Иванов А.В.Khomyakov V.M., Ivanov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpmj.ru/rpmj/article/view/96

Хирургическое лечение больных раком желудка с расширенной лимфаденэктомией нередко приводит к первичному (интраоперационная травма) и вторичному (воспалительные процессы в послеоперационном периоде) повреждению паренхимы поджелудочной железы. Частота развития панкреатитов в послеоперационном периоде, по данным различных авторов, достигает 20% и более. Среди медикаментозных методов профилактики особое место занимают синтетические аналоги соматостатина. Ранее проведенные исследования показали достоверное снижение частоты осложнений, в том числе формирования панкреатических фистул после операций на поджелудочной железе при использовании аналогов соматостатина. Использование прологнированных аналогов ССТ для профилактики послеоперационного панкреатита остается предметом исследований. В статье представлен обзор существующей литературы и собственный опыт профилактического использования «Октреотида-депо» у больных со злокачественными опухолями желудка, пищевода и кардии. 

Surgical treatment of patients with gastric cancer with extended lymph node dissection often leads to the primary (intra-operative injury) and secondary (inflammatory processes in the postoperative period) damage to the parenchyma of the pancreas. The incidence of pancreatitis in the postoperative period, according to various authors, reaches 20% or more. Synthetic analogues of somatostatin occupy the special place among the pharmacological methods of prophylaxis. Earlier studies have shown a significantly lower rate of complications, including the formation of pancreatic fistula after operations on the pancreas when using somatostatin analogues. Usage of prolonged SST analogues for the prevention of postoperative pancreatitis remains a matter of research. The article presents a review of existing literature and own experience with prophylactic use of «Оctreotide depot » in patients with malignant tumors of the stomach, esophagus and the cardia

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The authors declare that there are no conflicts of interest present.