rpmjResearch'n Practical Medicine JournalResearch and Practical Medicine Journal2410-1893"QUASAR", LLC10.17709/2410-1893-2024-11-1-5TLBFTQrpmj-978Research ArticleОбзорыReviewРадиомика и радиогеномика при внутрипеченочной холангиокарциномеRadiomics and radiogenomics in intrahepatic cholangiocarcinomahttps://orcid.org/0000-0002-5470-0999СмирноваА. Д.SmirnovaA. D.

 

Смирнова Александра Дмитриевна – врач-рентгенолог, аспирант отделения лучевых методов диагностики ФГБУ «Национальный медицинский исследовательский центр хирургии им. А. В. Вишневского» Министерства здравоохранения Российской Федерации, г. Москва, Российская Федерация

ORCID: https://orcid.org/0000-0002-5470-0999

 

Alexandra D. Smirnova – MD, radiologist, PhD student at the Department of Radiation Diagnostic Methods, A. V. Vishnevsky National Medical Research Center of Surgery of the Ministry of Health of Russian Federation, Moscow, Russian Federation

ORCID: https://orcid.org/0000-0002-5470-0999

alexa199503@yandex.ruhttps://orcid.org/0000-0002-9357-0998КармазановскийГ. ГKarmazanovskyG. G.

 

Кармазановский Григорий Григорьевич – д.м.н., профессор, академик РАН, заведующий отделением лучевых методов диагностики ФГБУ «Национальный медицинский исследовательский центр хирургии им. А. В. Вишневского» Министерства здравоохранения Российской Федерации, г. Москва, Российская Федерация; профессор кафедры лучевой диагностики и терапии медико-биологического факультета ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова» Министерства здравоохранения Российской Федерации, г. Москва, Российская Федерация

ORCID: https://orcid.org/0000-0002-9357-0998, SPIN: 5964-2369, Author ID: 338639, Scopus Author ID: 55944296600

 

Grigory G. Karmazanovsky – Dr. Sci. (Medicine), Professor, Academician RAS, Head of the Department of Radiation Diagnostic Methods, A. V. Vishnevsky National Medical Research Center of Surgery of the Ministry of Health of Russian Federation, Moscow, Russian Federation; Professor of the Department of Radiation Diagnostics and Therapy of the Faculty of Medicine and Biology, Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation, Moscow, Russian Federation

ORCID: https://orcid.org/0000-0002-9357-0998, SPIN: 5964-2369, Author ID: 338639, Scopus Author ID: 55944296600

karmazanovsky@yandex.ruhttps://orcid.org/0000-0001-7070-3391КондратьевЕ. В.KondratyevE. V.

 

Кондратьев Евгений Валерьевич – к.м.н., старший научный сотрудник отделения лучевых методов диагностики ФГБУ «Национальный медицинский исследовательский центр хирургии им. А. В. Вишневского» Министерства здравоохранения Российской Федерации, г. Москва, Российская Федерация

ORCID: https://orcid.org/0000-0001-7070-3391, SPIN: 2702-6526, AuthorID: 243610, Scopus Author ID: 55865664400, ResearcherID: ABD-5758-2020

 

Evgeny V. Kondratyev – Cand. Sci. (Medicine), Senior Researcher, Department of Radiation Diagnostic Methods, A. V. Vishnevsky National Medical Research Center of Surgery of Surgery of the Ministry of Health of Russian Federation, Moscow, Russian Federation

ORCID: https://orcid.org/0000-0001-7070-3391, SPIN: 2702-6526, AuthorID: 243610, Scopus Author ID: 55865664400, ResearcherID: ABD-5758-2020

https://orcid.org/0000-0001-8723-8916КарельскаяН. А.KarelskayaN.  A.

 

Карельская Наталья Александровна – к.м.н., старший научный сотрудник отделения лучевых методов диагностики ФГБУ «Национальный медицинский исследовательский центр хирургии им. А. В. Вишневского» Министерства здравоохранения Российской Федерации, г. Москва, Российская Федерация

ORCID: https://orcid.org/0000-0001-8723-8916, SPIN: 9921-1430, AuthorID: 899039, Scopus Author ID: 57192546234

 

Natalia A. Karelskaya – Cand. Sci. (Medicine), Senior Researcher, Department of Radiation Diagnostic Methods, A. V. Vishnevsky National Medical Research Center of Surgery of Surgery of the Ministry of Health of Russian Federation, Moscow, Russian Federation

ORCID: https://orcid.org/0000-0001-8723-8916, SPIN: 9921-1430, AuthorID: 899039, Scopus Author ID: 57192546234

https://orcid.org/0000-0002-6619-6179ГалкинВ. Н.GalkinV. N.

 

Галкин Всеволод Николаевич – д.м.н., профессор, главный врач ГБУЗ «Городская клиническая больница им. С. С. Юдина» Департамента здравоохранения г. Москвы, г. Москва, Российская Федерация

ORCID: https://orcid.org/0000-0002-6619-6179, SPIN: 3148-4843, AuthorID: 750069, Scopus Author ID: 57190568178

 

Vsevolod N. Galkin – Dr. Sci. (Medicine), Professor, Chief physician S. S. Yudin City Clinical Hospital of the Ministry of Health of Russia, Moscow, Russian Federation

ORCID: https://orcid.org/0000-0002-6619-6179, SPIN: 3148-4843, AuthorID: 750069, Scopus Author ID: 57190568178

https://orcid.org/0000-0001-6267-8237ПоповА. Ю.PopovA.  Yu.

 

Попов Анатолий Юрьевич – к.м.н., заведующий отделением противоопухолевой лекарственной терапии ФГБУ «Национальный медицинский исследовательский центр хирургии им. А. В. Вишневского» Министерства здравоохранения Российской Федерации, г. Москва, Российская Федерация

ORCID: https://orcid.org/0000-0001-6267-8237, SPIN: 6197-2060, AuthorID: 1177757, Scopus Author ID: 57192589967

 

Anatoly Yu. Popov – Cand. Sci. (Medicine), Head of the Department of Anticancer Drug Therapy, A. V. Vishnevsky National Medical Research Center of Surgery of the Ministry of Health of Russian Federation, Moscow, Russian Federation

ORCID: https://orcid.org/0000-0001-6267-8237, SPIN: 6197-2060, AuthorID: 1177757, Scopus Author ID: 57192589967

   

https://orcid.org/0000-0001-5958-3608ГурмиковБ. Н.GurmikovB. N.

 

Гурмиков Беслан Нуралиевич – д.м.н., доцент, заведующий онкологическим отделением хирургических методов лечения ФГБУ «Национальный медицинский исследовательский центр хирургии им. А. В. Вишневского» Министерства здравоохранения Российской Федерации, г. Москва, Российская Федерация

ORCID: https://orcid.org/0000-0001-5958-3608, SPIN: 1322-3629, AuthorID: 727742, Scopus Author ID: 57211081722

 

Beslan N. Gurmikov – Dr. Sci. (Medicine), Associate Professor, Head of the Oncological Department of Surgical Methods of Treatment, A. V. Vishnevsky National Medical Research Center of Surgery of the Ministry of Health of Russian Federation, Moscow, Russian Federation

ORCID: https://orcid.org/0000-0001-5958-3608, SPIN: 1322-3629, AuthorID: 727742, Scopus Author ID: 57211081722

https://orcid.org/0000-0001-6247-9481КалининД. В.KalininD. V.

 

Калинин Дмитрий Валерьевич – к.м.н., врач-патологоанатом патологоанатомического отделения ФГБУ «Национальный медицинский исследовательский центр хирургии им. А. В. Вишневского» Министерства здравоохранения Российской Федерации, г. Москва, Российская Федерация

ORCID: https://orcid.org/0000-0001-6247-9481, SPIN: 5563-5376, Author ID: 758757, Scopus Author ID: 57224357019, Researcher ID: N-9383-2015

 

Dmitry V. Kalinin – Cand. Sci. (Medicine), Pathologist of Anatomical Pathology Department, A. V. Vishnevsky National Medical Research Center of Surgery of the Ministry of Health of Russian Federation, Moscow, Russian Federation

ORCID: https://orcid.org/0000-0001-6247-9481, SPIN: 5563-5376, Author ID: 758757, Scopus Author ID: 57224357019, Researcher ID: N-9383-2015

Национальный медицинский исследовательский центр хирургии им. А. В. Вишневского<p> г. Москва, Российская ФедерацияA. V. Vishnevsky National Medical Research Center of Surgery of the Ministry of Health of Russian Federation<p> Moscow, Russian FederationНациональный медицинский исследовательский центр хирургии им. А. В. Вишневского<p> г. Москва, Российская Федерация <p> Российский национальный исследовательский медицинский университет им. Н. И. Пирогова<p> г. Москва, Российская ФедерацияA. V. Vishnevsky National Medical Research Center of Surgery of the Ministry of Health of Russian Federation<p> Moscow, Russian Federation <p> Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation <p> Moscow, Russian FederationГородская клиническая больница им. С. С. Юдина<p> г. Москва, Российская ФедерацияS. S. Yudin City Clinical Hospital of the Ministry of Health of Russia<p> Moscow, Russian Federation2024160220241115469Copyright &#x00A9; Смирнова А.Д., Кармазановский Г.Г., Кондратьев Е.В., Карельская Н.А., Галкин В.Н., Попов А.Ю., Гурмиков Б.Н., Калинин Д.В., 20242024Смирнова А.Д., Кармазановский Г.Г., Кондратьев Е.В., Карельская Н.А., Галкин В.Н., Попов А.Ю., Гурмиков Б.Н., Калинин Д.В.Smirnova A.D., Karmazanovsky G.G., Kondratyev E.V., Karelskaya N.A., Galkin V.N., Popov A.Y., Gurmikov B.N., Kalinin D.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpmj.ru/rpmj/article/view/978Цель исследования

Цель исследования. Аналитический обзор и анализ литературы, посвященной текстурному анализу компьютерных (КТ) и магнитно-р езонансных томограмм (МРТ) в неинвазивной диагностике внутрипеченочной холангиокарциномы (ВПХК) и корреляции с молекулярно- генетическими особенностями и иммунофенотипом опухоли.

Материалы и методы

Материалы и методы. Проведен поиск научных публикаций и клинических рекомендаций в информационно- аналитических системах PubMed, Scopus за 2012–2022 гг. по ключевым словам: «mri» (МРТ), «radiomics» (радиомика), «texture analysis» (текстурный анализ), «radiogenomics» (радиогеномика), «intrahepatic cholangiocarcinoma» (внутрипеченочный холангиоцеллюлярный рак), «molecular» (молекулярная). После исключения исследований, посвященных техническим аспектам радиомики и описанию отдельных клинических наблюдений, для анализа было отобрано 49 статей.

Результаты

Результаты. Представленный обзор продемонстрировал широкие возможности и перспективы применения текстурного анализа КТ и МРТ при изучении холангиоцеллюлярного рака, в том числе получены первые результаты в исследовании молекулярных особенностей (сигнатур) этой опухоли. Показана корреляция текстурных характеристик с экспрессией генов иммунотерапевтических мишеней KRAS/NRAS/BRAF, а также мутации IDH1/2. Показатели текстурного анализа были преобладающим независимым предиктором микроваскулярной инвазии, который был основным независимым фактором риска послеоперационного рецидива.

Заключение

Заключение. Применение текстурного анализа, безусловно, демонстрирует перспективные возможности как в неинвазивной оценке степени гистологической дифференцировки ВПХК, так и в дифференциальной диагностике с гепатоцеллюлярной карциномой и метастазами и требует дальнейшего изучения для систематизации и стандартизации полученных данных.

Purpose of the study

Purpose of the study. Analytical review and analysis of available literature on texture analysis of computed tomgraphy (CT) and magnetic resonance imaging (MRI) in noninvasive diagnosis of ICC and correlation with molecular genetic features and tumor immunophenotype.

Materials and methods

Materials and methods. The scientific publications and clinical guidelines in the information- analytical systems PubMed, Scopus for 2012–2022 were carried out using the keywords: "mri", "radiomics", "texture analysis", "radiogenomics", "intrahepatic cholangiocarcinoma", "molecular". 49 articles were selected for analysis after excluding studies dealing with technical aspects of radiomics and describing individual clinical observations.

Results

Results. The presented review demonstrated the broad possibilities and prospects of application of CT and MRI texture analysis in the study of cholangiocellular cancer, including the first results in the study of molecular features (signatures) of this tumor. Correlation of texture features with the expression of immunotherapy target genes KRAS/NRAS/BRAF as well as IDH1/2 mutation was shown. Texture scores were the predominant independent predictor of microvascular invasion, which was a major independent risk factor for postoperative recurrence.

Conclusion

Conclusion. The use of texture analysis undoubtedly demonstrates promising possibilities both in noninvasive assessment of the HCC histological differentiation grade, as well as in differential diagnosis with hepatocellular carcinoma, metastases, and requires further study for systematization and standardization of the obtained data.

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The authors declare that there are no conflicts of interest present.