Clinical observation of rib resection using a patient-specific 3D implant in the surgical treatment of chondrosarcoma
G. V. Afonin,
D. Yu. Mironova,
E. I. Smolenov,
Z. M. Salimov,
A. A. Kurilchik,
M. S. Bondar,
S. A. Ivanov,
A. D. Kaprin https://doi.org/10.17709/2410-1893-2026-13-1-8
EDN: XNXKAU
Abstract
To date, surgical treatment remains the main therapeutic option for patients with chest wall tumors. Given the importance of preserving the structural integrity of the thoracic cage during extensive resections, the choice of reconstruction method for post-resection chest wall defects remains one of the key challenges in thoracic surgery.
This clinical case report presents the treatment outcomes of a 64‑year-old female patient diagnosed with primary multiple metachronous malignancies who underwent rib resection followed by alloplastic reconstruction using a patient-specific 3D implant made of a nickel–titanium alloy. The implant was designed based on an individualized model and featured a double-locking mechanism using clamp-type fixation. At the 12‑month follow-up, no evidence of tumor recurrence was detected; the implant remained stable, the physiological volume of the thoracic cavity was preserved, and no signs of paradoxical respiration were observed.
The proposed patient-specific modular 3D implant is convenient for intraoperative placement, allowing minimization of the risk of bleeding and infectious complications, as well as reduction of operative time. The technique of sternal and rib reconstruction using a patient-specific modular 3D implant is safe and effective and can be widely implemented in clinical practice.
About the Authors
G. V. Afonin
https://new.nmicr.ru/mrrc/
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre
Obninsk, Russian Federation
Grigoriy V. Afonin – Cand. Sci. (Medicine), Head of the Department of Oncology, A.Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Obninsk, Russian Federation ORCID: https://orcid.org/0000-0002-7128-2397 eLibrary SPIN: 9039-6110, AuthorID: 896307 Scopus Author ID: 57204696417 WoS ResearcherID: O-3150-2017
Competing Interests:
Andrey D. Kaprin is the Editor-in-Chief of the Journal «Research’n Practical Medicine Journal» and one of the authors of the article. Sergey A. Ivanov is the Member of the Editorial Board of the Journal «Research’n Practical Medicine Journal» and one of the authors of the article The article has passed the review procedure accepted in the Journal by independ ent experts. The authors did not declare any other conflicts of interest.
D. Yu. Mironova
https://new.nmicr.ru/mrrc/
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre
Obninsk, Russian Federation
Diana Yu. Mironova – MD, oncologist, Department of Thoracic Oncology, A.Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Obninsk, Russian Federation ORCID: https://orcid.org/0000-0002-6665-5355 eLibrary SPIN: 3586-5146, AuthorID: 1066046 Scopus Author ID: 58509867400
Competing Interests:
Andrey D. Kaprin is the Editor-in-Chief of the Journal «Research’n Practical Medicine Journal» and one of the authors of the article. Sergey A. Ivanov is the Member of the Editorial Board of the Journal «Research’n Practical Medicine Journal» and one of the authors of the article The article has passed the review procedure accepted in the Journal by independ ent experts. The authors did not declare any other conflicts of interest.
E. I. Smolenov
https://new.nmicr.ru/mrrc/
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre
Obninsk, Russian Federation
Evgeny I. Smolenov – Cand. Sci. (Medicine), Senior Research Fellow, Department of Thoracic Oncology, A.Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Obninsk, Russian Federation ORCID: https://orcid.org/0000-0003-3782-7338 eLibrary SPIN: 6376-2673, AuthorID: 808954 Scopus Author ID: 57202278816
Competing Interests:
Andrey D. Kaprin is the Editor-in-Chief of the Journal «Research’n Practical Medicine Journal» and one of the authors of the article. Sergey A. Ivanov is the Member of the Editorial Board of the Journal «Research’n Practical Medicine Journal» and one of the authors of the article The article has passed the review procedure accepted in the Journal by independ ent experts. The authors did not declare any other conflicts of interest.
Z. M. Salimov
https://new.nmicr.ru/mrrc/
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre
Obninsk, Russian Federation
Zavir M. Salimov – MD, oncologist, Department of Thoracic Oncology, A.Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Obninsk, Russian Federation
Competing Interests:
Andrey D. Kaprin is the Editor-in-Chief of the Journal «Research’n Practical Medicine Journal» and one of the authors of the article. Sergey A. Ivanov is the Member of the Editorial Board of the Journal «Research’n Practical Medicine Journal» and one of the authors of the article The article has passed the review procedure accepted in the Journal by independ ent experts. The authors did not declare any other conflicts of interest.
A. A. Kurilchik
https://new.nmicr.ru/mrrc/
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre
Obninsk, Russian Federation
Alexander A. Kurilchik – Cand. Sci. (Medicine), oncologist, orthopedic surgeon and traumatologist, pediatric oncologist; Head of the Department of Bone, Soft Tissue, and Skin Tumors, A.Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Obninsk, Russian Federation ORCID: https://orcid.org/0000-0001-5329-8419 eLibrary SPIN: 1751-0982, AuthorID: 737423 Scopus Author ID: 57200540281 WoS ResearcherID: H-7857-2018
Competing Interests:
Andrey D. Kaprin is the Editor-in-Chief of the Journal «Research’n Practical Medicine Journal» and one of the authors of the article. Sergey A. Ivanov is the Member of the Editorial Board of the Journal «Research’n Practical Medicine Journal» and one of the authors of the article The article has passed the review procedure accepted in the Journal by independ ent experts. The authors did not declare any other conflicts of interest.
M. S. Bondar
https://www.nsu.ru/n/
Novosibirsk State University
Novosibirsk State University
Novosibirsk, Russian Federation
Matvey S. Bondar – design engineer, senior lecturer, department of physical methods of solid-state research, Novosibirsk State University, Novosibirsk, Russian Federation
Competing Interests:
Andrey D. Kaprin is the Editor-in-Chief of the Journal «Research’n Practical Medicine Journal» and one of the authors of the article. Sergey A. Ivanov is the Member of the Editorial Board of the Journal «Research’n Practical Medicine Journal» and one of the authors of the article The article has passed the review procedure accepted in the Journal by independ ent experts. The authors did not declare any other conflicts of interest.
S. A. Ivanov
https://new.nmicr.ru/mrrc/
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Obninsk, Russian Federation;
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Obninsk, Russian Federation;
Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation
Sergey A. Ivanov – Dr. Sci. (Medicine), Corresponding Member of the RAS, Director of A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Obninsk, Russian Federation; Professor of the Department of Oncology and Radiology named after V.P. Kharchenko at the Medical Institute, Peoples' Friendship University of Russia, Moscow, Russian Federation ORCID: https://orcid.org/0000-0001-7689-6032 eLibrary SPIN: 4264-5167, AuthorID: 710405 Scopus Author ID: 16070399200 WoS ResearcherID: N-8221-2017
Competing Interests:
Andrey D. Kaprin is the Editor-in-Chief of the Journal «Research’n Practical Medicine Journal» and one of the authors of the article. Sergey A. Ivanov is the Member of the Editorial Board of the Journal «Research’n Practical Medicine Journal» and one of the authors of the article The article has passed the review procedure accepted in the Journal by independ ent experts. The authors did not declare any other conflicts of interest.
A. D. Kaprin
National Medical Research Radiological Centre, Obninsk, Russian Federation;
P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre, Moscow, Russian Federation;
Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation
Andrey D. Kaprin – Dr. Sci. (Medicine), Professor, Academician of the Russian Academy of Sciences, Academician of the Russian Academy of Education, Director of P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre, Moscow, Russian Federation, General Director of National Medical Research Radiological Centre, Obninsk, Russian Federation, Head of the Department of Oncology and Radiology named after V.P. Kharchenko at the Medical Institute, Peoples' Friendship University of Russia, Moscow, Russian Federation ORCID: https://orcid.org/0000-0001-8784-8415 eLibrary SPIN: 1759-8101, AuthorID: 96775 Scopus Author ID: 6602709853 WoS ResearcherID: K-1445-2014
Competing Interests:
Andrey D. Kaprin is the Editor-in-Chief of the Journal «Research’n Practical Medicine Journal» and one of the authors of the article. Sergey A. Ivanov is the Member of the Editorial Board of the Journal «Research’n Practical Medicine Journal» and one of the authors of the article The article has passed the review procedure accepted in the Journal by independ ent experts. The authors did not declare any other conflicts of interest.
References
1. Goldsmith I. Chest Wall Reconstruction With 3D Printing: Anatomical and Functional Considerations. Innovations (Phila). 2022 May- Jun;17(3):191–200. https://doi.org/10.1177/15569845221102138
2. Wen X, Gao S, Feng J, Li S, Gao R, Zhang G. Chest-wall reconstruction with a customized titanium-alloy prosthesis fabricated by 3D printing and rapid prototyping. J Cardiothorac Surg. 2018 Jan 8;13(1):4. https://doi.org/10.1186/s13019-017-0692-3
3. Goldsmith I, Dovgalski L, Evans PL. 3D Printing Technology for Chest Wall Reconstruction With a Sternum-Ribs-Cartilage Titanium Implant: From Ideation to Creation. Innovations (Phila). 2023 Jan-Feb;18(1):67–72. https://doi.org/10.1177/15569845231153632
4. Kang J, Tian Y, Zheng J, Lu D, Cai K, Wang L, Li D. Functional design and biomechanical evaluation of 3D printing PEEK flexible implant for chest wall reconstruction. Comput Methods Programs Biomed. 2022 Oct;225:107105. https://doi.org/10.1016/j.cmpb.2022.107105
5. Li Y, Liu K, Yang Y, Zhao T, Guo X, Wang L. Mastery of chest wall reconstruction with a titanium sternum-rib fixation system: a case series. J Thorac Dis. 2022 Dec;14(12):5064–5072. https://doi.org/10.21037/jtd-22-1686
6. Jungraithmayr W, Laube I, Hild N, Stark WJ, Mihic-Probst D, Weder W, Buschmann J. Bioactive nanocomposite for chest-wall replacement: Cellular response in a murine model. J Biomater Appl. 2014 Jul;29(1):36–45. https://doi.org/10.1177/0885328213513621
7. Berthet JP, Gomez Caro A, Solovei L, Gilbert M, Bommart S, Gaudard P, Canaud L, Alric P, Marty-Ané CH. Titanium Implant Failure After Chest Wall Osteosynthesis. Ann Thorac Surg. 2015 Jun;99(6):1945–1952. https://doi.org/10.1016/j.athoracsur.2015.02.040
8. Tamburini N, Grossi W, Sanna S, Campisi A, Londero F, Maniscalco P, Dolci G, Quarantotto F, Daddi N, Morelli A, Cavallesco G, Dell'Amore A. Chest wall reconstruction using a new titanium mesh: a multicenters experience. J Thorac Dis. 2019 Aug;11(8):3459–3466. https://doi.org/10.21037/jtd.2019.07.74
9. Aramini B, Masciale V, Radaelli LFZ, Sgarzani R, Dominici M, Stella F. The sternum reconstruction: Present and future perspectives. Front Oncol. 2022 Oct 28;12:975603. https://doi.org/10.3389/fonc.2022.975603
10. Dzian A, Živčák J, Penciak R, Hudák R. Implantation of a 3D-printed titanium sternum in a patient with a sternal tumor. World J Surg Oncol. 2018 Jan 15;16(1):7. https://doi.org/10.1186/s12957-018-1315-8
11. Wang W, Yang S, Han M, Liu H, Feng Q, Su Y, Han Y, Wang J. Three-dimensional printed titanium chest wall reconstruction for tumor removal in the sternal region. J Cardiothorac Surg. 2024 Oct 1;19(1):579. https://doi.org/10.1186/s13019-024-03078-y
12. Martinez-Ferro M, Bellia-Munzon G, Toselli L, Sanjurjo D. The role of 3D printing in chest wall reconstruction. J Thorac Dis. 2024 Jun 30;16(6):4053–4063. https://doi.org/10.21037/jtd-23-881
13. Kurilchik AA, Usachev VS, Ivanov VE, Starodubtsev AL, Zubarev AL. Forms of sternal reconstruction in oncology. Grekov's Bulletin of Surgery. 2021;180(2):57–62. (In Russ.). https://doi.org/10.24884/0042-4625-2021-180-2-57-62
14. A patent for an invention №2760620 от 29.11.2021. Method for thoracic defect replacement by individual 3d implant. Authors: Kurilchik AA, Starodubtsev AL, Ivanov VE, Zubarev AL, Kolobaev IV, Afonin GV, Usachev VS, Aliev MBD, Ryabov AB, Krasovsky IB, Panchenko AA, Kaprin AD. (In Russ.).
15. Rudakov SS. Isolated and syndromic chest development defects and their treatment. Diss. Moscow,1988. (In Russ.).
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For citations:
Afonin G.V., Mironova D.Yu., Smolenov E.I., Salimov Z.M., Kurilchik A.A., Bondar M.S., Ivanov S.A., Kaprin A.D. Clinical observation of rib resection using a patient-specific 3D implant in the surgical treatment of chondrosarcoma. Research and Practical Medicine Journal. 2026;13(1):95-103. (In Russ.) https://doi.org/10.17709/2410-1893-2026-13-1-8. EDN: XNXKAU
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