THE POSSIBILITY OF HIFU THERAPY AT THE PRESENT STAGE

Writing this article is prompted by growing interest in the technology of high intensity focused ultrasound (high-intensity focused ultrasound, HIFU), which, in turn, is associated with a wide range of potential points of use, minimal invasiveness of this method, minimal impact on the patient’s body, characterized by a short period of rehabilitation. Also, this treatment method has a high reproducibility, which in turn contributes to the rapid spread of HIFU therapy in practice. The review is devoted to the history of development, study and application of the method of ultrasonic ablation, the modern view on how to conduct HIFU therapy, the currently available technical possibilities for non-invasive high-intensity focused ultrasound therapy as well as demonstrate the effectiveness of this treatment in patients with malignant and benign tumors of different localization, as in a standalone version or in combination with other treatment options (surgery, drug therapy, radiation therapy), an attempt to systematize the early and remote results of treatment. The article represents the data of world and national literature. One of the important directions of the study of the described technique is an expansion of possible application in various malignant pathologies, both local and generalized nature of the lesion. A separate item is the application of HIFU therapy in the treatment of chronic pain syndrome.

1. Wood R. W., Loomis A. The physical and biological effects of high frequency soundwaves of great intensity. Phil. Mag. 1927;4:417.

2. Lynn J. G., Zwemer R. L., Chick A. J., Miller A. G. A new method for the generation and use of focused ultrasound in experimental biology. J Gen Physiol. 1942;26:179–93. Available at: http://jgp.rupress.org/content/26/2/179.long

3. Fry W. J., Mosberg W. H., Barnard J. W., Fry F. J. Production of focal destructive lesions in the central nervous system with ultrasound. J Neurosurg. 1954;11:471–8. DOI: 10.3171/jns.1954.11.5.0471

4. Fry W. J., Barnard J. W., Krumins R. F., Brennan J. F. Ultrasonic lesions in the mammalian central nervous system. Science.1955;122:517–8. Available at: http://science.sciencemag.org/content/122/3168/517.long

5. Fry F. J. Precision high-intensity focusing ultrasonic machines for surgery. Am J Phys Med. 1958;37:152–6.

6. Ballantine H. T., Bell E., Manlapaz J. Progress and problems in the neurological application of focused ultrasound. J Neurosurg. 1960;17:858–76. DOI: 10.3171/jns.1960.17.5.0858.

7. Warwick R., Pond J. B. Trackless lesions in nervous tissues produced by HIFU (high-intensity mechanical waves). J Anat. 1968;102:387–405. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1231478/

8. Lele P. P. Concurrent detection of the production of ultrasonic lesions. Med Biol Eng. 1966;4:451–6.

9. Lele P. P. Production of deep focal lesions by focused ultrasound – current status. Ultrasonics. 1967;5:105–12.

10. Christian E., Cheng Yu, Apuzzo M. L. J. Focused ultrasound: relevant history and prospects for the addition of mechanical energy to the neurosurgical armamentarium. World Neurosurg. 2014 Sep-Oct;82 (3–4):354–65. DOI: 10.1016/j.wneu.2014.06.021.

11. Burov A. K. High-intensity ultrasonic vibrations for action on animal and human malignant tumours. Dokl Akad Nauk SSSR. 1956;106:239–41.

12. Taylor K. J.W, Connolly CC. Differing hepatic lesions caused by the same dose of ultrasound. J Pathol. 1969;98:291–3. DOI: 10.1002/path.1710980410.

13. Rozenberg L. D. Fokusiruyushchie izluchateli ul’trazvuka [Focusing ultrasound transducers]. In: Fizika i tekhnika moshchnogo ul’trazvuka [Physics and technique of powerful ultrasound]. Ed by Rozenberg L. D. Vol. 1. Istochniki moshchnogo ul’trazvuka [Sources of powerful ultrasound]. Moscow: “Nauka” Publ., 1967, pp. 149–206. (In Russian).

14. Vartanyan I. A., Gavrilov L. R., Gershuni G. V., Rozenblyum A. S., Tsirul’nikov E. M. Sensornoe vospriyatie. Opyt issledovaniya s pomoshch’yu fokusirovannogo ul’trazvuka [Sensory perception. Experience of investigation by focused ultrasound]. L.: “Nauka” Publ., 1985, 189 p. (In Russian).

15. Zhou Y. F. High intensity focused ultrasound in clinical tumor ablation. World J Clin Oncol. 2011;2 (1):8–27. DOI: 10.5306/wjco.v2.i1.8.

16. Chen L., ter Haar G. R., Hill C. R., Dworkin M., Carnochan P., Young H., et al. Effect of blood perfusion on the ablation of liver parenchyma with high-intensity focused ultrasound. Phys Med Biol. 1993;38:1661–73. Available at: http://iopscience.iop.org/article/10.1088/0031–9155/38/11/011/meta;jsessionid=61757B00473065216D5A4C-53B96CC155.c1.iopscience.cld.iop.org

17. Karpov O. E., Vetshev P. S., Zhivotov V. А. Ultrasound tumour ablation: the current status and new opportunities. Bulletin of Pirogov National Medical & Surgical Center. 2008;3 (2):77–82. (In Russian).

18. Hynynen K., Pomeroy O., Smith D. N., Huber P. E., McDannold N. J., Kettenbach J., et al. MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: A feasibility study. Radiology 2001;219:176–85. DOI: 10.1148/radiology.219.1.r01ap02176.

19. Wu F., Wang Z. B., Wang Z. L., et al. Changes in ultrasonic image of tissue damaged by high intensity ultrasound in vivo. J Acoustic Soc Am. 1998;103:2869.

20. Schlosser J., Vallancien G. High-intensity focused ultrasound ablative surgery for bladder cancer. Atlas of the Urologic Clinics of North America. 1997;5:125–41.

21. Koehrmann K. U., Michel M. S., Steidler A., Marlinghaus E., Kraut O., Aiken P. Technical characterization of an ultrasound source for non-invasive thermoablation by high-intensity focused ultrasound. Br J Urol (Int). 2002;90:248–52. Available at: http://onlinelibrary.wiley.com/doi/10.1046/j.1464–410X.2002.02848.x/full

22. Sviridova T. I. Neinvazivnaya distantsionnaya fokusirovannaya ul’trazvukovaya ablyatsiya (HIFU) vtorichnykh obrazovanii pecheni [Remote non-invasive high-intensity focused ultrasound ablation (HIFU) of secondary structures of the liver]. Мoscow: N. I. Pirogov National Medical Surgical Center, 2014. (In Russian).

23. Gianfelice D., Khiat A., Boulanger Y., Amara M., Belblidia A. Feasibility of magnetic resonance imaging-guided focused ultrasound surgery as an adjunct to tamoxifen therapy in high-risk surgical patients with brest carcinoma. J Vase Interv Radiol. 2003; (14):1275–1282.

24. Stewart E. A., Gedroyc W. M., Tempany C. M., Quade B. J., Inbar Y., Ehrenstein T., et al. Focused treatment of uterine fibroid tumors: safety and feasibility of a noninvasive thermoablative technique. Am J Obstet Gynecol. 2003;189:48–54. DOI: 10.1067/mob.2003.345.

25. Wu F., Wang Z. B., Chen W. Z. et al. Non-invasive ablation of high intensity focused ultrasound for the treatment of patients with malignant bone tumors. J Bone Joint Surg. (Br). 2005;87:4.

26. Stewart E. A., Gostout B., Rabinovici J., Kim H. S., Regan L., Tempany C. M. Sustained relief of leiomyoma symptoms by using focused ultrasound surgery. Obstet Gynecol. 2007;110 (2 pt 1): 279–87. DOI: 10.1097/01.AOG.0000275283.39475.f6.

27. Vallencien G., Harouni M., Vellion B., et al. Focused extracorporeal pyrotherapy: Feasibility study in man. J Endourol. 1992;6:173– 181.

28. Thuroff S., Chaussy C., Vallancien G., Wieland W., Kiel H. J., Le Duc A., et al. High-intensity focused ultrasound and localized prostate cancer: efficacy results from the European multicentric study. J Endourol. 2003;17:673–7. DOI: 10.1089/089277903322518699.

29. Blana A., Walter B., Rogenhofer S., Wieland W. F. High-intensity focused ultrasound for the treatment of localized prostate cancer: 5‑year experience. Urology 2004 Feb;63 (2):297–300. DOI: 10.1016/j.urology.2003.09.020.

30. Uchida T., Illing R. O., Cathcart P. J., Emberton M. To what extent does the prostate-specific antigen nadir predict subsequent treatment failure after transrectal high-intensity focused ultrasound therapy for presumed localized adenocarcinoma of the prostate? BJU Int. 2006 Sep;98 (3):537–9. DOI: 10.1111/j.1464–410X.2006.06297.x

31. Blana |A., Rogenhofer S., Ganzer R., Lunz J. C., Schostak M., Wieland W. F., et al. Eight years’ experience with high-intensity focused ultrasonography for treatment of localized prostate cancer. Urology. 2008 Dec;72 (6):1329–33; discussion 1333–4. DOI: 10.1016/j.urology.2008.06.062.

32. Trapeznikova M. F., Pozdnyakov K. V. Nablyudenie i vedenie patsientov s rakom predstatel’noi zhelezy posle vypolneniya ul’trazvukovoi ablyatsii [Monitoring and management of patients with prostate cancer after performing ultrasonic ablation]. Moscow: The State Budgetary Healthcare Institution of Moscow Area Moscows regional research clinical institute N. A. M. F. Vladimirskiy, 2014, 16 p. (In Russian).

33. Solovov V. A., Thüroff S., Chaussy C., Vozdvizhenskiy M. O., Matyash Y. S., Fesenko D. V. High-intensity focused ultrasound ablation (HIFU) in the treatment of prostate cancer: status quo 2014. Malignant Tumoursis. 2014;3 (10):52–6. DOI: 10.18027/2224–5057–2014–3-52–56 (In Russian).

34. Slabozhankina E. A. Vozmozhnosti ul’trazvukovoi ablatsii (HIFU) v lechenii miomy matki [Ultrasound ablation (HIFU) in the treatment of uterine fibroids]. Мoscow, 2014. (In Russian).