PHYTOTHERAPY FOR INFLAMMATORY DISEASES OF THE PROSTATE
https://doi.org/10.17709/2409-2231-2019-6-3-8
Abstract
The article discusses the effectiveness of herbal medicine in inflammatory diseases of the prostate. This literature review presents clinical studies of the successful use of herbal ingredients in the treatment of chronic prostatitis and relief of lower urinary tract symptoms (LUTS). Biological active substances of Urtica dioica, Cucurbita moschata, Saw palmetto (Serenoa repens), and zinc are effective in the treatment of chronic prostatitis due to anti-inflammatory, antiproliferative, antiandrogenic and antioxidant action. Phytopreparations containing these substances can be recommended as the first line of correction of LUTS in chronic forgive categories III and IV; as a general tonic for men leading a sedentary lifestyle over the age of 35 years.
Keywords
phytotherapy,
chronic bacterial prostatitis,
Saw palmetto,
Serenoa repens,
Cucurbita moschata,
Urtica dioica,
zinc,
lower urinary tract symptoms (LUTS)
Supporting agencies: The research was carried out with the support of the “CSC Ltd” company. The study sponsors and the third parties have not been involved in the processing and analysis of the data and the writing of this article.
About the Authors
N. G. Kulchenko
Medical Institute of Peoples' Friendship University of Russia (RUDN University)
Russian Federation
MD, PhD, urologist, ultrasound medical specialist, senior lectures of the departments of histology, cytology and embryology
Competing Interests: Аuthors report no conflict of interest.
Russian Federation
MD, PhD, urologist, ultrasound medical specialist, senior lectures of the departments of histology, cytology and embryology
Competing Interests: Аuthors report no conflict of interest.
E. V. Yatsenko
Medical Clinic “MediCos”
Russian Federation
MD, PhD, urologist, ultrasound medical specialist, deputy chief physician
Competing Interests: Аuthors report no conflict of interest.
Russian Federation
MD, PhD, urologist, ultrasound medical specialist, deputy chief physician
Competing Interests: Аuthors report no conflict of interest.
References
1. Pirola GM, Verdacchi T, Rosadi S, Annino F, De Angelis M. Chronic prostatitis: current treatment options. Res Rep Urol. 2019 Jun 4;11:165–174. DOI: 10.2147/RRU.S194679
2. Clemens JQ, Meenan RT, O’Keeffe Rosetti MC, Kimes T, Calhoun EA. Prevalence of and risk factors for prostatitis: population based assessment using physician assigned diagnoses. J Urol. 2007 Oct;178 (4 Pt 1):1333–7. DOI: 10.1016/j.juro.2007.05.140
3. Nickel JC. Prostatitis. Canadian Urological Association Journal. 2011;5 (5):306–5. DOI: 10.5489/cuaj.11211
4. Pontari MA, Joyce GF, Wise M, McNaughton-Collins M. Urologic Diseases in America Project. Prostatitis. J Urol. 2007 Jun;177 (6):2050–7. DOI: 10.1016/j.juro.2007.01.128
5. Apolihin OI, Komarova VA, Nikushina AA, Sivkov AV. Prostate diseases in the Russian Federation: statistical data for 2008– 2017. Experimental and Clinical Urology. 2019;2:4–13. DOI: 10.29188/2222–8543–2019–11–2-4–12 (In Russian)
6. Krieger JN, Nyberg L Jr, Nickel JC. NIH consensus definition and classification of prostatitis. JAMA. 1999 Jul 21;282 (3):236–7. DOI: 10.1001/jama.282.3.236
7. Vinogradov IV, Zhivulko AR, Korolev SV. Chronic prostatitis, pathogenetic mechanisms of influence on male fertility. Journal of Postgraduate Medical Education. 2018;4:48–54. (In Russian)
8. Stamatiou K, Pierris N. Serenoa repens extract additionally to quinolones in the treatment of chronic bacterial prostatitis. The preliminary results of a long term observational study. Arch Ital Urol Androl. 2013 Dec 31;85 (4):190–6. DOI: 10.4081/aiua.2013.4.190
9. Wagenlehner FM, van Till JW, Magri V, Perletti G, Houbiers JG, Weidner W, Nickel JC. National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) symptom evaluation in multinational cohorts of patients with chronic prostatitis/chronic pelvic pain syndrome. Eur Urol. 2013 May;63 (5):953–9. DOI: 10.1016/j.eururo.2012.10.042
10. Kaprin AD, Kostin AA, Popov SV. Medikamentoznaya terapiya khronicheskogo prostatita. RMJ (Russian Medical Journal). 2015;23 (17):1010–2. (In Russian)
11. Weidner W. Treating chronic prostatitis: antibiotics no, alpha-blockers maybe. Ann Intern Med. 2004 Oct 19;141 (8):639–40. DOI: 10.7326/0003–4819–141-8–200410190–00012
12. Popov SV, Mazo EВ. Etiotropic therapy of chronic bacterial prostatitis. Urology. 2008;3:36–41. (In Russian)
13. Cunha BA, Gran A, Raza M. Persistent extended-spectrum β-lactamase-positive Escherichia coli chronic prostatitis successfully treated with a combination of fosfomycin and doxycycline. Int J Antimicrob Agents. 2015 Apr;45 (4):427–9. DOI: 10.1016/j. ijantimicag.2014.12.019
14. Magri V, Boltri M, Cai T, Colombo R, Cuzzocrea S, De Visschere P, et al. Multidisciplinary approach to prostatitis. Arch Ital Urol Androl. 2019 Jan 18;90 (4):227–248. DOI: 10.4081/aiua.2018.4.227
15. Engelmann U, Walther C, Bondarenko B, Funk P, Schlafke S. Efficacy and safety of a combination of sabal and urtica extract in lower urinary tract symptoms. A randomized, double-blind study versus tamsulosin. Arzneimittelforschung. 2006;56 (3):222–9. DOI: 10.1055/s-0031–1296714
16. Hu M, Wazir J, Ullah R, Wang W, Cui X, Tang M, Zhou X. Phytotherapy and physical therapy in the management of chronic prostatitis-chronic pelvic pain syndrome. Int Urol Nephrol. 2019 Jul;51 (7):1081–1088. doi: 10.1007/s11255–019–02161-x
17. Saavedra MJ, Aires A, Dias C, Almeida JA, De Vasconcelos MC, Santos P, Rosa EA. Evaluation of the potential of squash pumpkin by-products (seeds and shell) as sources of antioxidant and bioactive compounds. J Food Sci Technol. 2015 Feb;52 (2):1008–15. DOI: 10.1007/s13197–013–1089–5
18. Safarinejad MR. Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. J Herb Pharmacother. 2005;5 (4):1–11
19. De Monte C, Carradori S, Granese A, Di Pierro GB, Leonardo C, De Nunzio C. Modern extraction techniques and their impact on the pharmacological profile of Serenoa repens extracts for the treatment of lower urinary tract symptoms. BMC Urol. 2014 Aug 11;14:63. DOI: 10.1186/1471–2490–14–63
20. Damiano R, Cai T, Fornara P, Franzese CA, Leonardi R, Mirone V. The role of Cucurbita pepo in the management of patients affected by lower urinary tract symptoms due to benign prostatic hyperplasia: A narrative review. Arch Ital Urol Androl. 2016 Jul 4;88 (2):136–43. DOI: 10.4081/aiua.2016.2.136
21. Chrubasik JE, Roufogalis BD, Wagner H. A comprehensive review on the stinging nettle effect and efficacy profiles Part II: Urtica radix. Phytomedicine. 2007 Aug;14 (7–8):568–79. DOI: 10.1016/j.phymed.2007.03.014
22. Kulchenko NG. Optimizing the conservative therapy of benign prostatic hyperplasia by inhibitors of 5–alfareductase. Clinical and morphological study. Kursk scientific and practical bulletin «Man and his health». 2012;1:101–6. (In Russian)
23. Yang J, Te AE. Saw palmetto and finasteride in the treatment of category-III prostatitis/chronic pelvic pain syndrome. Curr Urol Rep. 2005 Jul;6 (4):290–5
24. Gordon AE, Shaughnessy AF. Saw palmetto for prostate disorders. Am Fam Physician. 2003 Mar 15;67 (6):1281–3
25. Colado-Velázquez J, Mailloux-Salinas P, Medina-Contreras JML, Cruz-Robles D, Bravo G. Effect of Serenoa repens on oxidative stress, inflammatory and growth factors in obese wistar rats with benign prostatic hyperplasia. Phytother Res. 2015 Oct;29 (10):1525–31. DOI: 10.1002/ptr.5406
26. Penugonda K, Lindshield B. Fatty acid and phytosterol content of commercial saw palmetto supplements. Nutrients. 2013 Sep 13;5 (9):3617–33. DOI: 10.3390/nu5093617
27. Procida G, Stancher B, Cateni F, Zacchigna M. Chemical composition and functional characterisation of commercial pumpkin seed oil. J Sci Food Agric. 2013 Mar 30;93 (5):1035–41. DOI: 10.1002/jsfa.5843
28. Tantawy SA, Elgohary HM, Kamel DM. Trans-perineal pumpkin seed oil phonophoresis as an adjunctive treatment for chronic nonbacterial prostatitis. Res Rep Urol. 2018 Sep 18;10:95–101. DOI: 10.2147/RRU.S167896
29. Hong H, Kim CS, Maeng S. Effects of pumpkin seed oil and saw palmetto oil in Korean men with symptomatic benign prostatic hyperplasia. Nutr Res Pract. 2009 Winter;3 (4):323–7. DOI: 10.4162/nrp.2009.3.4.323
30. Guan Q, Zheng Y, Wei X, Wang S, Su B, Yu S. The Effect of Flavonoids on Chronic Prostatitis: A Meta-analysis of Published Randomized Controlled Trials. J Natl Med Assoc. 2019 May 23. pii: S0027–9684 (19)30011–2. DOI: 10.1016/j.jnma.2019.04.007
31. Schilcher H, Dunzendorfer U, Ascali F. D7-Sterols: the prostatotropic principle of pumpkin seeds. Urologe B. 1987;27:316–319
32. Abdel-Rahman MK. Effect of pumpkin seed (Cucurbita pepo L) diets on benign prostatic hyperplasia (BPH): chemical and morphometric evaluation in rats. World J Chem. 2006;1 (1):33–40
33. Moradi HR, Erfani Majd N, Esmaeilzadeh S, Fatemi Tabatabaei SR. The histological and histometrical effects of Urtica dioica extract on rat’s prostate hyperplasia. Vet Res Forum. 2015 Winter;6 (1):23–9
34. Pigat N, Reyes-Gomez E, Boutillon F, Palea S, Barry Delongchamps N, Koch E, Goffin V. Combined Sabal and Urtica Extracts (WS® 1541) Exert Anti-proliferative and Anti-inflammatory Effects in a Mouse Model of Benign Prostate Hyperplasia. Front Pharmacol. 2019 Mar 29;10:311. DOI: 10.3389/fphar.2019.00311
35. Dhouibi R, Affes H, Ben Salem M, Hammami S, Sahnoun Z, Zeghal KM, Ksouda K. Screening of pharmacological uses of Urtica dioica and others benefits. Prog Biophys Mol Biol. 2019 Jun 1. pii: S0079–6107 (19)30098–7. DOI: 10.1016/j.pbiomolbio.2019.05.008
36. Cheetham PJ. Role of complimentary therapy for male LUTS. Curr Urol Rep. 2013 Dec;14 (6):606–13. DOI: 10.1007/s11934–013–0372–3
37. Powell SR. The antioxidant properties of zinc. J Nutr. 2000May;130(5S Suppl):1447S-54S. DOI: 10.1093/jn/130.5.1447S
38. Costello LC, Franklin RB. A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancer. Arch Biochem Biophys. 2016 Dec 1;611:100–112. DOI: 10.1016/j.abb.2016.04.014
39. Flynn A, Hirvonen T, Mensink GB, Ocké MC, Serra-Majem L, Stos K, et al. Intake of selected nutrients from foods, from fortifi-cation and from supplements in various European countries. Food Nutr Res. 2009 Nov 12;53. DOI: 10.3402/fnr.v53i0.2038
40. Cui D, Han G, Shang Y, Mu L, Long Q, Du Y. The effect of chronic prostatitis on zinc concentration of prostatic fluid and seminal plasma: a systematic review and meta-analysis. Curr Med Res Opin. 2015;31 (9):1763–9. DOI: 10.1185/03007995.2015.1072707
41. Goodarzi D, Cyrus A, Baghinia MR, Kazemifar AM, Shirincar M. The efficacy of zinc for treatment of chronic prostatitis. Acta Med Indones. 2013 Oct;45 (4):259–64
Review
For citations:
Kulchenko N.G., Yatsenko E.V. PHYTOTHERAPY FOR INFLAMMATORY DISEASES OF THE PROSTATE. Research and Practical Medicine Journal. 2019;6(3):87-97. (In Russ.) https://doi.org/10.17709/2409-2231-2019-6-3-8
Views:
4734
Email this article 