Dental status of patients with squamous cell carcinoma of the oropharyngeal region
https://doi.org/10.17709/2409-2231-2019-6-4-11
Abstract
Purpose of the study. To evaluate changes in the oral cavity in patients with squamous cell carcinoma of the oropharyngeal region after radiation therapy.
Materials and methods. The study included 70 patients with oropharyngeal squamous cell carcinoma. All patients underwent external beam radiation therapy. We used dose fractionation mode: 5 fractions per week, single focal dose — 2G. The severity of oral mucositis was assessed using the RTOG evaluation scale.
Results. Patients with carcinoma of the oropharyngeal region before the start of the main treatment had pathology of hard tooth tissues (CPU-14.62±1.08), gingival inflammation (PMA-41.71±4.98), periodontal inflammation (CPITN-2.54±0.62). After the end of radiation therapy, oral mucositis was detected in all patients (100%). We found changes in the negative side for all indicators of dental status indices compared to primary CPUs-15.26±0.90; CPITN-3.36±0.58; PMA-49.75±5.28 (p<0.05). Clinical signs of oral mucositis begin to appear as early as 7 days after the start of radiation therapy, RTOG=1,5. After 3 weeks, patients develop severe mucosal lesions with fibrinous plaque and severe pain syndrome (RTOG=3.0), requiring intensive drug therapy (p<0.05).
Conclusion. In connection with the early appearance of post-radiation oral mucositis, preventive and therapeutic measures to improve the regeneration.
About the Authors
A. M. Avanesov
Peoples Friendship University of Russia (RUDN University); Russian Scientific Center of Roentgenoradiology (RSCRR)
Russian Federation
Russian Federation
Anatoliy M. Avanesov - MD, PhD, DSc, professor, head of the department of general and clinical dentistry Peoples Friendship University of Russia (RUDN University).
6 MikLukho-MakLaja str., Moscow 1171984; 86 Profsoyuznaya str., Moscow 117997.
E. N. Gvozdikova
Peoples Friendship University of Russia (RUDN University)
Russian Federation
Russian Federation
Eugeniya N. Gvozdikova - MD, PhD, associate professor of general and clinical debintistry Medical Institute of Peoples Friendship University of Russia (RUDN University).
6 MikLukho-MakLaja str., Moscow 117198.
D. A. Khaydar
Peoples Friendship University of Russia (RUDN University)
Russian Federation
Russian Federation
Dalila A. Khaydar - assistant of general and clinical dentistry Medical Institute of Peoples Friendship University of Russia (RUDN University).
6 MikLukho-MakLaja str., Moscow 117198.
T. V. Tarasova
National Research Ogarev Mordovia State University
Russian Federation
Russian Federation
Tatyana V. Tarasova - PhD, DSc (Biology), professor of the department of normal physiology and pathophysiology chair of Medical Institute of National Research Ogarev Mordovia State University.
68 Bolshevistskaya str., Saransk 430005, Republic of Mordovia.
I. V. Saushev
National Research Ogarev Mordovia State University
Russian Federation
Russian Federation
Igor V. Saushev - MD, PhD, DSc, Professor of anesthesiology and resuscitation department of Medical Institute of National Research Ogarev Mordovia State University.
68 Bolshevistskaya str., Saransk 430005, Republic of Mordovia
E. P. Tyurina
National Research Ogarev Mordovia State University
Russian Federation
Russian Federation
Elena P. Tyurina - MD, PhD, associate professor of obsterics and gynecology of Medical Institute of National Research Ogarev Mordovia State University.
68 Bolshevistskaya str., Saransk 430005, Republic of Mordovia.
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Review
For citations:
Avanesov A.M., Gvozdikova E.N., Khaydar D.A., Tarasova T.V., Saushev I.V., Tyurina E.P. Dental status of patients with squamous cell carcinoma of the oropharyngeal region. Research and Practical Medicine Journal. 2019;6(4):109-115. (In Russ.) https://doi.org/10.17709/2409-2231-2019-6-4-11
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