Возможности радиогеномики в оценке ответа и долговременной выживаемости при неоадъювантном лечении рака молочной железы

Рак молочной железы (РМЖ) – наиболее распространенное злокачественное заболевание. Применение неоадъювантной лекарственной терапии повышает вероятность достижения полного патоморфологического ответа (pCR), ведет к повышению резектабельности и абластики; способствует определению чувствительности опухолевых клеток к химиопрепаратам, тем самым улучшая прогноз пациента. Поскольку патоморфологическая оценка происходит после операции, необходимо развитие методов неинвазивной оценки ответа для своевременной коррекции объема проводимого лечения. Одним из таких методов является метод магнитно-резонансной томографии (МРТ). Оценка полученных изображений с использованием текстурного анализа позволяет повысить точность метода как при контроле лечения в неоадъювантном режиме, так и при оценке ответа на назначенную неоадъювантную терапию при предоперационном планировании.

В настоящей статье представлен анализ литературных данных о возможности повышения прогностической ценности МРТ молочных желез в оценке полного патоморфологического ответа при неоадъювантном лекарственном лечении РМЖ с использованием текстурного анализа данных.

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