Preview

Research and Practical Medicine Journal

Advanced search

THE USE OF PHOTOD YNAMIC THERAPY IN THE DOMESTIC ONCOLOGY. (REVIEW OF THE LITERA TURE)

https://doi.org/10.17709/2409-2231-2015-2-4-98-105

Abstract

In this paper, it has been tasked to demonstrate progress is Russian scientists who are pioneers in the application of clinical photodynamic therapy (PDT) in Europe. In this review current understanding of the mechanisms of action PDT on the tumor and the body, the technical aspects of the application of the laser radiation of varying intensity, particularly its effect on biological tissues. The results of studies on the use of PDT with different photosensitizers in the complex therapeutic measures in patients with cancer. The data on the efficacy and safety of PDT. Given the effectiveness of PDT and ease of use, no adverse reactions, this medical technology can be attributed to one of the most promising trends in oncology. Accumulated a large experience of PDT in oncology testifies to high efficiency of this method in the treatment of various tumors. However, despite the positive results obtained in clinical practice, PDT in oncology is not widely used.

It is proposed to implement this knowledge into the educational process at universities. Researchers of the А. Tsyb MRRC and Obninsk Institute for Nuclear Power Engineering (MEPhI) are working under development of educational complex program «Medical physics». This cooperation is expected to improve professional training and education in health physics.

About the Author

V. V. Kuznetsov
INPE MEPhI (Obninsk, Russia) Campus 1, Kaluga region, Obninsk, 249040, Russia
Russian Federation
PhD, Docent, Head of the practice of students and graduates INPE MEPhI


References

1. Dougherty T. J., Kaufman J. E., Goldfarb A., Weishaupt K. R., Boyle D., Mittleman A. Photoradiation therapy for the treatment of malignant tumours. Cancer Res. 1978; 38: 2628–2635.

2. Huggett M. T., Jermyn M., Gillams A., Illing R., Mosse S., Novelli M, Kent E., Bown S. G., Hasan T., Pogue B. W., Pereira S. P. Phase I/II study of verteporfin photodynamic therapy in locally advanced pancreaticcancer. Br J Cancer. 2014; 110 (7): 1698–1704.

3. Hillemanns P., Garcia F., Petry K. U., Dvorak V., Sadovsky O., Iversen O. E., Einstein M. H. A randomized study of hexaminolevulinate photodynamic therapy in patients with cervical intraepithelial neoplasia 1/2. Am J Obstet Gynecol. 2015; 212 (4): 465.e1–465.e7.

4. Rigual N., Shafirstein G., Cooper M. T., Baumann H., Bellnier D. A., Sunar U., Tracy E C, Rohrbach D. J., Wilding G., Tan W., Sullivan M., Merzianu M., Henderson B. W. Photodynamic therapy with 3- (1’-hexyloxyethyl) pyropheophorbide a for cancer of the oral cavity. Clin Cancer Res. 2013; 19 (23): 6605–6613.

5. Ikeda H., Tobita T., Ohba S., Uehara M., Asahina I. Treatment outcome of Photofrin-based photodynamic therapy for T1 and T2 oral squamous cell carcinoma and dysplasia. Photodiagnosis Photodyn Ther. 2013; 10 (3): 229–235.

6. Eymerit-Morin C., Zidane M., Lebdai S., Triau S., Azzouzi A. R., Rousselet M. C. Histopathology of prostate tissue after vascular- targeted photodynamic therapy for localized prostate cancer. Virchows Arch. 2013; 463 (4): 547–552.

7. Cai X. J., Li W. M., Zhang L. Y., Wang X. W., Luo R. C., Li L. B. Photodynamic therapy for intractable bronchial lung cancer. Photodiagnosis Photodyn Ther. 2013; 10 (4): 672–676.

8. Ramirez D. P., Kurachi C., Inada N. M., Moriyama L. T., Salvio A. G., Vollet Filho J. D., Pires L., Buzzá H. H., de Andrade C. T., Greco C., Bagnato V. S. Experience and BCC subtypes as determinants of MAL-PDT response: preliminary results of a national Brazilian project. Photodiagnosis Photodyn Ther. 2014; 11 (1): 22–26.

9. Stranadko E. F. Main stages of development of photodynamic therapy in Russia. Fotodinamicheskaya terapiya i fotodiagnostika. 2015; 1: 3–10. (Russian).

10. Kaplan M. A., Romanko Yu. S. Laser photodynamic therapy. Fizioterapiya, Bal’neologiya i Reabilitatsiya. 2004; 1: 43–48. (Russian).

11. Filonenko E. V. Fluorescence diagnostics and photodynamic therapy: justification of applications and opportunities in oncology. Photodynamic therapy and photodiagnostics. 2014; 1: 3–7. (Russian).

12. Romanko Yu. S., Kaplan М. А., Popuchiev V. V. Mechanisms of action of photodynamic therapy with Photoditazin at sarcoma M-l Lazernaya medicina. 2004; 8 (3): 232. (Russian).

13. Tsyb A. F., Kaplan M. A., Romanko Yu. S., Popuchiev V. V. Fotodinamicheskaya terapiya. Moscow: «MIA» Publ., 2009. (Russian).

14. Kaplan M. A., Romanko Y. S., Popuchiev V. V., Yuzhakov V. V., Bandurko L. N., Mikhina L. N., Fomina N. K., Malygina A. I., Ingel I. Influence of light energy density at antineoplastic efficiency of photodynamic therapy with photoditazin. Lazernaya medicina. 2005; 9 (2): 46–54. (Russian).

15. Kaplan M. A., Romanko Y. S., Popuchiev V. V., Yuzhakov V. V., Bandurko L. N., Fomina N. K., Mikhina L. N., Malygina A. I., Ingel I. E. Action of photodynamic therapy with photoditazin on growth and functional morphology of sarcoma M-l. Lazernaya medicina. 2005; 9 (4): 41–47. (Russian).

16. Romanko Yu. S., Tsyb A. F., Kaplan M. A., Popuchiev V. V. Effect of photodynamic therapy with photodithazine on morphofunctional parameters of M-1 sarcoma. Bulletin of Experimental Biology and Medicine. 2004; 138 (6): 584–589.

17. Romanko Yu. S., Tsyb A. F., Kaplan M. A., Popuchiev V. V. Relationship between antitumor efficiency of photodynamic therapy with photoditasine and photoenergy density. Bulletin of Experimental Biology and Medicine. 2005; 139 (4): 460–464.

18. Kaplan M. A., Romanko Yu. S., Popuchiev V. V., Yuzhakov V. V., Bandurko L. N. Morfofunktsional’nye osobennosti sarkomy M-1 pri fotodinamicheskoi terapii s ispol’zovaniem fotosensibilizatora fotoditazin. Rossiiskiy bioterapevticheskiy zhurnal. 2004; 3 (2): 52. (Russian).

19. Romanko Yu. S. Fotodinamicheskaya terapiya bazal’nokletochnogo raka kozhi (eksperimental’no-klinicheskoe issledovanie). Avtroref. dis. … dokt. med. nauk: 14.00.19/Med. rad. nauch. tsentr. Obninsk, 2005. (Russian).

20. Romanko Yu. S., Tsyb A. F., Kaplan M. A., Popuchiev V. V. Relationship between antitumor efficiency of photodynamic therapy with photoditasine and photoenergy density. Bulletin of Experimental Biology and Medicine. 2005; 139 (4): 456–461. (Russian).

21. Kaplan M. A., Kapinus V. N., Popuchiev V. V., Romanko Yu. S., Yaroslavtseva-Isaeva E. V., Spichenkva I. S., Shubina A. M., Borgul O. V., Goranskaya E. V. Photodynamic therapy: results and prospects. Radiation and Risk. 2013; 22 (3): 115–123. (Russian).

22. Kaplan M. A., Nikitina R. G., Romanko Yu. S., Bozadzhiev L. L., Malygina A. I., Drozhzhina V. V. Fotodinamicheskaya terapiya sarkomy M-1 u eksperimental’nykh zhivotnykh. Lazernaya medicina 1998; 2 (2–3): 38–42. (Russian).

23. Kaplan M. A., Nikitina R. G., Malygina A. I., Romanko Yu. S., Bozadzhiev L. L., Drozhzhina V. V., Arkhipova L. M., Deev V. V., Smakhtin L. A. The potential of rose bengal treatment for photodynamic therapy of tumors. Voprosy oncologii. 1999; 45 (5): 557–559. (Russian).

24. Kaplan M. A., Ponomarev G. V., Baum R. F., Romanko Yu. S., Mardynskaya V. P., Malygina A. I. Izuchenie spetsificheskoi fotodinamicheskoi aktivnosti fotoditazina pri fotodinamicheskoi terapii sarkomy M-1 u krys. Rossiiskiy bioterapevticheskiy zhurnal. 2003; 2 (4): 23–30. (Russian).

25. Kaplan M. A., Romanko Yu. S., Mardynskaya V. P., Malygina A. I., Burmistrova N. V., Yaroslavtseva-Isaeva E. V., Spichenkova I. V. Razrabotka metoda fotodinamicheskoi terapii s fotoditazinom u eksperimental’nykh zhivotnykh s sarkomoi M-1. Rossiiskiy bioterapevticheskiy zhurnal. 2004; 3 (2): 52. (Russian).

26. Molochkov V. A., Romanko Yu. S., Popuchiyev V. V., Sukhova T. Ye., Taranets T. A., Kaplan M. A. Impact of photodynamic therapy using Photoditazin on the morphofunctional characteristics of sarcoma M-1. Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei. 2005; 5: 58–63. (Russian).

27. Romanko Yu. S., Tsyb A. F., Kaplan M. A., Popuchiev V. V. Vliyanie fotodinamicheskoi terapii s Fotoditazinom na morfofunktsional’nye kharakteristiki sarkomy M-1. Bulletin of Experimental Biology and Medicine. 2004; 138 (12): 658–664. (Russian).

28. Romanko Yu. S., Popuchiev V. V., Molochkov V. A., Sukhova T. Ye., Taranets T. A., Yuzhakov V. V., Safinova L. Sh. Relationship of the antitumor efficiency of photodynamic therapy for sarcoma M-1 with Photoditazin (chlorine E6) to the density of light energy. Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei. 2007; 6: 55–59. (Russian).

29. Tsyb A. F., Kaplan M. A., Molochkov V. A., Mironov A. F., Romanko Yu. S., Kapinus V. N., Tretyakova Ye. I., Sukhova T.Ye. Use of photodynamic therapy in the treatment of solitary and multiple basal-cell carcinomas. Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei. 2000; 4: 4–12. (Russian).

30. Yaroslavtseva-Isaeva E. V., Kaplan M. A., Romanko Yu. S., Sokol N. I. Razrabotka metodiki fotodinamicheskoi terapii eksperimental’noi opukholi (sarkoma M-1) pri lokal’nom vvedenii fotosensibilizatora. Rossiiskiy bioterapevticheskiy zhurnal. 2003; 2 (4): 19–22. (Russian).

31. Taranets T. A., Sukhova T. E., Romanko Yu. S. Fotodinamicheskaya terapiya bazal’no-kletochnogo raka kozhi s lokal’nym i vnutrivennym ispol’zovaniem fotosensibilizatora khlorinovogo ryada «Fotolon». Medical Almanac. 2007; 15: 283–288. (Russian).

32. Suchova T. E., Molochkov V. A., Romanko Yu. S., Matveyeva O. V., Reshetnikov A. V. The present day therapy of cutaneous basal cell carcinoma. Medical Almanac. 2008; 18: 14–21. (Russian).

33. Sukhova T. E., Romanko Yu. S., Yaroslavtseva-Isaeva E. V., Korenev S. V., Prokof’ev A. A. Vnutritkanevoi variant vvedeniya fotosensibilizatora pri fotodinamicheskoi terapii bazal’no-kletochnogo raka kozhi (soobshchenie 1). Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei. 2010; 2: 4–10. (Russian).

34. Sukhova T. E., Romanko Yu. S., Molochkov A. V., Tret’yakova E. I. K topicheskoi fotodinamicheskoi terapii bazal’no-kletochnogo raka kozhi.//Sbornik nauchnykh rabot Nauchno-prakticheskoi konferentsii dermatovenerologov Tsentral’nogo federal’nogo okruga RF «Aktual’nye voprosy dermatovenerologii i dermatoonkologii». Moscow, 2011, pp. 60–65. (Russian).

35. Molochkov A. V., Sukhova T. E., Tretyakova E. I., Akopova K. V., Koroleva L. P., Prokofyev A. A., Rumyantsev S. A., Alieva P. M., Romanko Yu. S., Molochkov V. A. Comparative evaluation of the efficiency of laser-induced and photodynamic therapy for surface and micronodular basaloma. Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei. 2012; 4: 30–36. (Russian).

36. Molochkov A. V., Romanko Y. S., Kazantseva K. V., Sukhova T. E., Popuchiev V. V., Tret’yakova E. I., Matveeva O. V., Kuntsevich Z. S., Molochkova Y. V., Prokofev A. A., Dibirova S. D.. Laser-induced thermotherapy and photodynamic therapy in dermatology: opportunities and future horizons. Medical Almanac. 2014; 34: 30–35. (Russian).

37. Molochkov A. V., Kaprin A. D., Galkin V. N., Molochkov V. A., Kaplan M. A., Suhova T. E., Ivanov S. A., Romanko Yu. S., Popuchiev V. V., Epatova T. V. Application of photodynamic therapy for basal cell carcinoma using a local photosensitizer Photolon. Radiation and Risk. 2015; 24 (1): 108–117. (Russian).

38. Kapinus V. K., Romanko Yu. S., Kaplan M. A., Ponomarev G. V., Sokol N. I. Effektivnost’ flyuorestsentnoi diagnostiki i fotodinamicheskoi terapii s fotosensibilizatorom fotoditazin u bol’nykh rakom kozhi. Rossiiskiy bioterapevticheskiy zhurnal. 2005; 4 (3): 69–75. (Russian).

39. Kaplan M. A., Kapinus V. N., Romanko Yu. S., Yaroslavtseva-Isaeva E. V. Fotoditazin — effektivnyi fotosensibilizator dlya fotodinamicheskoi terapii. Rossiiskiy bioterapevticheskiy zhurnal. 2004; 3 (2): 50. (Russian).

40. Tsyb A. F., Kaplan M. A., Romanko Yu. S., Popuchiev V. V. Klinicheskie aspekty fotodinamicheskoi terapii. Kaluga: Izdatel’stvo nauchnoi literatury N. F. Bochkarevoi, 2009. (Russian).

41. Romanko Yu. S., Korenev S. V., Popuchiev V. V., Vaisbein I. Z., Sukhova T. E. Osnovy fotodinamicheskoi terapii. Kaliningrad: «Strazh Baltiki» Publ., 2010. (Russian).

42. Volgin V. N., Stranadko E. F., Trishkina O. V., Kabanova M. A., Kagoyants R. V. Comparative characteristics of therapies for cutaneous basal-cell carcinoma. Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei. 2013; 16 (5): 4–10. (Russian).

43. Romanko Yu. S., Kaplan M. A., Popuchiev V. V., Molochkov V. A., Sukhova T.Ye., Tretyakova B. I., Taranets T. A. Basal cell carcinoma of the skin: the problems of treatment and the current aspects of photodynamic therapy. Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei. 2004; 6: 6–10. (Russian).

44. Molochkov V. A., Snarskaya Ye. S., Polyakov P. Yu., Afonin A. V., Sukhova T. Ye., Romanko Yu. S., Khlebnikova A. N., Taranets T. A., Koroleva L. P., Kladova A. Yu., Chelyukanova M. V., Kozlova Ye. S. To the treatment of skin basaliomas Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei. 2005; 6: 4–9. (Russian).

45. Sukhova T.Ye., Romanko Yu. S., Matveyeva O. V. Photodynamic therapy for basal-cell carcinoma with the local application of radachlorine. Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei. 2008; 4: 41–44. (Russian).

46. Katsalap S. N., Romanko Yu. S. Vybor varianta fotodinamicheskoi terapii retsidivnoi bazaliomy. Vestnik esteticheskoi meditsiny. 2012; 11 (1): 44–48. (Russian).

47. Kaplan M. A., Romanko Yu. S., Popuchiev V. V. Atlas fotodinamicheskoi terapii. Moscow: «Littera» Publ., 2015. (Russian).

48. Kazantseva K. V., Molochkov A. V., Molochkov Vladimir A., Sukhova T. E., Prokofyev A. A., Kaprin A. D., Galkin V. N., Ivanov S. A., Kaplan M. A., Romanko Yu. S., Popuchiev V. V. Kaposi’s sarcoma: pathogenesis, clinical picture, diagnosis, and modern therapy. Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei. 2015; 18 (1): 7–15. (Russian).

49. Sukhova T. E., Molochkov V. A., Romanko Yu. S., Changlyan K. A., Tret’yakova E. I. Fotodinamicheskaya terapiya aktinicheskogo keratoza s applikatsionnym primeneniem «Fotoditazina». Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei. 2010; 5: 4–8. (Russian).

50. Molochkov V. A., Molochkov A. V., Sukhova T. E., Khlebnikova A. N., Kuntsevich Zh. S., Romanko Yu. S.1, Dibirova S. D., Bochkareva E. V. Local photodynamic therapy for keratoacanthoma. Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei. 2012; 4: 21–24. (Russian).

51. Evstigneev S. V., Kulaev M. T., Rybkina O. A. Photodynamic therapy and diagnosis of lower lip cancer with photosense. Photodynamic therapy and photodiagnostics. 2014; 3: 20–22. (Russian).

52. Korenev S. V., Vaisbein I. Z., Popuchiev V. V., Romanko Yu. S. Primenenie flyuorestsentnoi diagnostiki v opredelenii taktiki lecheniya raka vul’vy.//Sbornik nauchnykh rabot Mezhdunarodnoi nauchno-prakticheskoi konferentsii «Sovremennye tekhnologii akusherstva i ginekologii v reshenii problem demograficheskoi bezopasnosti». Kaliningrad, 2014; pp. 69–72. (Russian).

53. Korenev S. V., Romanko Yu. S. Vozmozhnosti fotodinamicheskoi terapii pri rake vul’vy.//Sbornik nauchnykh rabot Mezhdunarodnoi nauchno-prakticheskoi konferentsii «Sovremennye tekhnologii akusherstva i ginekologii v reshenii problem demograficheskoi bezopasnosti». Kaliningrad, 2014; pp. 72–76. (Russian).

54. Filonenko E. V., Chulkova O. V., Novikova E. G., Khoronenko V. E., Urlova A. N., Serova L. G. Fotodinamicheskaya terapiya raka vul’vy. Photodynamic therapy and photodiagnostics. 2014; 1: 49–50. (Russian).

55. Grebenkina E. V., Gamajunov S. V., Kuznetsov S. S., Onoprienko O. V., Illarionova N. A., Shakhova N. M. Photodynamic therapy for cervical lesions. Photodynamic therapy and photodiagnostics. 2014; 2: 12–14. (Russian).

56. Filonenko E. V., Sokolov V. V., Karpova E. S. Efficiency of photodynamic treatment in patients with early gastric cancer. Photodynamic therapy and photodiagnostics. 2013; 2: 3–6. (Russian).

57. Sokolov V. V., Filonenko E. V., Karpova E. S. Long-term palliative treatment of patient with signet ring cell gastric cancer using endoscopic photodynamic therapy. Photodynamic therapy and photodiagnostics. 2014; 3: 34–36. (Russian).

58. Chernyshev I., Altunin D., Samsonov U., Kallaev K. Photodynamic methods of diagnostics and treatment of prostate and kidney cancer: new possibilities. Experimental and Clinical Urology. 2011; 2–3: 92–94. (Russian).

59. Filonenko E. V., Kaprin A. D., Alekseev B.Ya., Urlova A. N. The case of successful photodynamic therapy in patient with erythroplasia of Queyrat. Photodynamic therapy and photodiagnostics. 2014; 2: 28–30. (Russian).

60. Chernyshev I. V., Altunin D. V., Samsonov Yu. V., Kudryavtsev Yu. V. Metody fluorestsentnoi diagnostiki i fotodinamicheskoi terapii v onkourologii. Nauchno-meditsinskii vestnik Tsentral’nogo Chernozem’ya. Nauchno-meditsinskii vestnik Tsentral’nogo Chernozem’ya. 2008; 34: 57–58. (Russian).

61. Chernyshev I. V., Altunin D. V., Samsonov Yu. V., Osipov O. V. Fotodinamicheskaya terapiya v kombinirovannom lechenii poverkhnostnogo raka mochevogo puzyrya. Nauchno-meditsinskii vestnik Tsentral’nogo Chernozem’ya. 2008; 34: 60–61. (Russian).

62. Sal’nikova S. V., Ivanchenko L. P. Kombinirovannaya terapiya neinvazivnogo raka mochevogo puzyrya s primeneniem FDT. Photodynamic therapy and photodiagnostics. 2012; 1: 22–23. (Russian).

63. Filonenko E. V., Kaprin A. D., Alekseev B.Ya., Apolikhin O. I., Vorozhzov G. N., Slovokhodov E. K., Ivanova-Radkevich V. I., Machinskaya E.A Intraoperative photodynamic therapy of bladder cancer with alasens (results of multicenter trial). Photodynamic therapy and photodiagnostics. 2014; 4: 23–25. (Russian).

64. Sokolov V. V., Telegina L. V., Gladyshev A. A., Pikin O. V., Trakhtenberg A.Kh., Chissov V. I., Frank G. A., Belous T. A., Menenkov V. D. Endoskopicheskaya vnutribronkhial’naya khirurgiya i fotodinamicheskaya terapiya pri rannem tsentral’nom rake legkogo. Photodynamic therapy and photodiagnostics. 2012; 1: 23–24. (Russian).

65. Sokolov V. V., Filonenko E. V. Photodynamic therapy in patients with early central lung cancer. Photodynamic therapy and photodiagnostics. 2013; 4: 3–6. (Russian).

66. Galkin V. N., Kaplan M. A., Ragulin Yu. A., Romanko Yu. S., Peters V. V., Epatova T. V. Sanatsionnaya bronkhoskopiya posle fotodinamicheskoy terapii v kombinirovannom lechenii raka legkogo.//Sbornik nauchnykh rabot VI Vserossiyskoy nauchno- prakticheskoy konferentsii s mezhdunarodnym uchastiem «Aktual’nye voprosy endoskopii. Sovremennye vozmozhnosti endoskopii v diagnostike i lechenii vzroslykh i detey». Saint Petersburg, 2015; pp. 135–136. (Russian).


Review

For citations:


Kuznetsov V.V. THE USE OF PHOTOD YNAMIC THERAPY IN THE DOMESTIC ONCOLOGY. (REVIEW OF THE LITERA TURE). Research and Practical Medicine Journal. 2015;2(4):98-105. (In Russ.) https://doi.org/10.17709/2409-2231-2015-2-4-98-105

Views: 4007


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2410-1893 (Online)