ГЕННО-ТЕРАПЕВТИЧЕСКИЕ ПРЕПАРАТЫ В ОНКОЛОГИИ: СОВРЕМЕННОЕ СОСТОЯНИЕ
https://doi.org/10.17709/2409-2231-2016-3-4-4
Аннотация
В обзорной статье рассмотрены современные данные мировой литературы об официальных лекарственных препаратах для генной терапии больных со злокачественными опухолями, а также данные о препаратах, завершивших все фазы клинических испытаний.
Освещена концепция генной терапии, приведены результаты статистического анализа инициированных клинических испытаний генных препаратов, указаны наиболее активно развивающиеся направления противоопухолевой генной терапии, подробно охарактеризованы препараты для онкологии.
Рассмотрены различные векторные системы доставки генетического материала – дефектные по репликации вирусы (препараты Gendicine™ и Advexin) и онколитические (опухолеспецифические условно размножающиеся) вирусы (препараты Oncorine™, ONYX-015, Imlygic®).
К настоящему времени в онкологическую клиническую практику введены 3 препарата для внутриопухолевого введения: 2 препарата зарегистрированы в Китае – Gendicine™ и Oncorine™ на основе дефектного по репликации и реплицирующегося аденовируса с эффекторным геном р53 дикого типа для лечения больных с опухолями головы-шеи, и 1 препарат зарегистрирован в США – Imlygic® на основе биоинженерного реплицирующегося штамма HSV1 с эффекторным геном GM–CSFдля лечения больных с меланомой. Препараты хорошо переносятся больными, не вызывают серьезных нежелательных явлений. Препараты Gendicine™ и Oncorine™ в монотерапии слабоэффективны, но проявляют выраженный синергизм действия с химиои лучевой терапией. Imlygic® – на начальной стадии изучения.
Об авторах
Е. Р. НемцоваРоссия
Немцова Елена Романовна - доктор биологических наук, ведущий научный сотрудник отделения модификаторов и протекторов противоопухолевой терапии.
125284 Москва, 2-й Боткинский пр., 3; E-mail: nemtz@yandex.ru
О. А. Безбородова
Россия
Безбородова Ольга Алексеевна - кандидат биологических наук, старший научный сотрудник отделения модификаторов и протекторов противоопухолевой терапии МНИОИ имени П. А. Герцена – филиал ФГБУ «НМИРЦ».
125284, Россия, Москва, 2-й Боткинский проезд, 3, E-mail: olgabezborodova@yandex.ru
Р. И. Якубовская
Россия
Якубовская Раиса Ивановна - доктор биологических наук, профессор, заведующая отделением модификаторов и протекторов противоопухолевой терапии МНИОИ имени П. А. Герцена – филиал ФГБУ «НМИРЦ».
125284, Россия, Москва, 2-й Боткинский проезд, 3, E-mail: raisayakub@yandex.ru
А. Д. Каприн
Россия
Каприн Андрей Дмитриевич - академик РАН, доктор медицинских наук, профессор, заведующий кафедрой урологии и оперативной нефрологии с курсом онкоурологии МИ РУДН, генеральный директор ФГБУ «НМИРЦ» Минздрава России.
125284, Россия, Москва, 2-й Боткинский проезд, 3
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Рецензия
Для цитирования:
Немцова Е.Р., Безбородова О.А., Якубовская Р.И., Каприн А.Д. ГЕННО-ТЕРАПЕВТИЧЕСКИЕ ПРЕПАРАТЫ В ОНКОЛОГИИ: СОВРЕМЕННОЕ СОСТОЯНИЕ. Research'n Practical Medicine Journal. 2016;3(4):33-43. https://doi.org/10.17709/2409-2231-2016-3-4-4
For citation:
Nemtsova E.R., Bezborodova O.A., Yakubovskaya R.I., Kaprin A.D. OFFICIAL MEDICATIONS FOR ANTI-TUMOR GENE THERAPY. Research and Practical Medicine Journal. 2016;3(4):33-43. (In Russ.) https://doi.org/10.17709/2409-2231-2016-3-4-4