LAMININS  IN COLORECTAL CANCER:  EXPRESSION, FUNCTION, PROGNOSTIC  POWER  AND MOLECULAR MECHANISMS

S. A. Rodin; D. V. Maltseva

doi:10.17709/2409-2231-2017-4-4-8

LAMININS IN COLORECTAL CANCER: EXPRESSION, FUNCTION, PROGNOSTIC POWER AND MOLECULAR MECHANISMS

S. A. Rodin, D. V. Maltseva

https://doi.org/10.17709/2409-2231-2017-4-4-8

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Abstract

Extracellular matrix (ECM) proteins are a major component of the tumor stroma. Laminins emerge as one of the main families of ECM proteins with signaling properties. Apart from the structural function, laminins and products of their degradation affect survival and differentiation of cancer cells, motility of cancer and stromal cells, angiogenesis, invasion into distant organs, and other aspects of cancer development. Here, we discus expression of laminins in colorectal cancer (CRC), studying of laminin functions in in vitro and in vivo models of CRC, and using laminins as prognostic markers of CRC. Recently, we have reported a new approach to assessing prognostic power using classifiers constructed from sets of laminin genes. The method allows for accurate prognosis of CRC and provides additional information that may suggest possible molecular mechanisms of laminin function in CRC progression.

Keywords

laminins, colorectal cancer, prognostic markers of cancer

About the Authors

S. A. Rodin

SRC Bioclinicum; Karolinska Institutet
Sweden

Sergey Rodin - PhD, senior researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, senior researcher at SRC Bioclinicum.

2 bld. 85 Ugreshskaya str., Moscow, 115088; 17177 Stockholm

D. V. Maltseva

SRC Bioclinicum
Russian Federation

Diana V. Maltseva, PhD, Deputy Director for Science, SRC Bioclinicum.

2 bld. 85 Ugreshskaya str., Moscow, 115088

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Review

For citations:

Rodin S.A., Maltseva D.V. LAMININS IN COLORECTAL CANCER: EXPRESSION, FUNCTION, PROGNOSTIC POWER AND MOLECULAR MECHANISMS. Research and Practical Medicine Journal. 2017;4(4):73-78. https://doi.org/10.17709/2409-2231-2017-4-4-8

This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 2410-1893 (Online)

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Research and Practical Medicine Journal