Preview

Исследования и практика в медицине

Расширенный поиск

Роль воспаления в течении и лечении колоректального рака

https://doi.org/10.17709/2409-2231-2018-5-4-4

Полный текст:

Аннотация

Одним из факторов, влияющих на эффективность лечения и определяющих прогноз заболевания больного колоректальным раком, может быть воспалительный статус как до, так и после оперативного лечения. Обзор посвящен описанию возможных механизмов связи воспалительного статуса в организме пациента и онкогенеза опухоли. Особое внимание уделено способности опухолевых клеток модифицировать клетки иммунной системы из противоонкогенных в проонкогенные. В работе рассмотрена попытка представления единой концепции влияния послеоперационных осложнений на рецидивирование опухоли в свете воспалительного ответа организма на оперативное вмешательство.

Об авторах

Т. Н. Гарманова
Клиника колопроктологии и малоинвазивной хирургии, ФГАОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет)
Россия

Гарманова Татьяна Николаевна - кандидат медицинских наук, доцент кафедры хирургии медико-профилактического факультета.

1/19435, Москва, ул. Погодинская, д. 1, стр. 1



М. И. Бредихин
Клиника колопроктологии и малоинвазивной хирургии, ФГАОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет)
Россия

Бредихин Михаил Игоревич - кандидат медицинских наук, ассистент кафедры хирургии медико-профилактического факультета.

1/19435, Москва, ул. Погодинская, д. 1, стр. 1



И. А. Тулина
Клиника колопроктологии и малоинвазивной хирургии, ФГАОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет)
Россия

Тулина Инна Андреевна - кандидат медицинских наук, доцент кафедры хирургии медико-профилактического факультета.

1/19435, Москва, ул. Погодинская, д. 1, стр. 1



П. В. Царьков
Клиника колопроктологии и малоинвазивной хирургии, ФГАОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет)
Россия

Царьков Пётр Владимирович - доктор медицинских наук, профессор, заведующий кафедрой хирургии медико-профилактического факультета.

1/19435, Москва, ул. Погодинская, д. 1, стр. 1



Список литературы

1. Longo WE, Virgo KS, Johnson FE, Oprian CA, Vernava AM, Wade TP, et al. Risk factors for morbidity and mortality after colectomy for colon cancer. Dis Colon Rectum. 2000 Jan;43 (1):83-91.

2. Collins TC, Daley J, Henderson WH, Khuri SF. Risk factors for prolonged length of stay after major elective surgery. Ann Surg. 1999 Aug;230 (2):251-9.

3. Khuri SF, Henderson WG, DePalma RG, Mosca C, Healey NA, Kumbhani DJ, et al. Determinants of long-term survival after major surgery and the adverse effect of postoperative complications. Ann Surg. 2005 Sep;242 (3):326-41; discussion 341-3.

4. Lagarde SM, de Boer JD, ten Kate FJW, Busch ORC, Obertop H, van Lanschot JJB. Postoperative complications after esophagectomy for adenocarcinoma of the esophagus are related to timing of death due to recurrence. Ann Surg. 2008 Jan;247 (1):71-6. DOI: 10.1097/SLA.0b013e31815b695e

5. Nespoli A, Gianoffi L, Totis M, Bovo G, Nespoli L, Chiodini P, et al. Correlation between postoperative infections and long-term survival after colorectal resection for cancer. Tumori. 2004 Sep-Oct;90 (5):485-90.

6. Klinger MHF, Jelkmann W. Review: Role of Blood Platelets in Infection and Inflammation. J Interferon Cytokine Res. 2002 Sep;22 (9):913-22. DOI: 10.1089/10799900260286623

7. Kono SA, Heasley LE, Doebele RC, Camidge DR. Adding to the Mix: Fibroblast Growth Factor and Platelet-Derived Growth Factor Receptor Pathways as Targets in Non — small Cell Lung Cancer. Curr Cancer Drug Targets. 2012 Feb;12 (2):107-23.

8. Suzuki K, Aiura K, Ueda M, Kitajima M. The influence of platelets on the promotion of invasion by tumor cells and inhibition by antiplatelet agents. Pancreas. 2004 Aug;29 (2):132-40.

9. Szkandera J, Pichler M, Absenger G, Stotz M, Arminger F, Weissmueller M, et al. The elevated preoperative platelet to lymphocyte ratio predicts decreased time to recurrence in colon cancer patients. Am J Surg. 2014 Aug;208 (2):210-4. DOI: 10.1016/j.amjsurg.2013.10.030

10. Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013 Nov;19 (11):1423-37. DOI: 10.1038/nm.3394

11. Roxburgh CS, McMillan DC. Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncol. 2010 Jan;6 (1):149-63. DOI: 10.2217/fon.09.136.

12. Leitch EF, Chakrabarti M, Crozier JEM, McKee RF, Anderson JH, Horgan PG, et al. Comparison of the prognostic value of selected markers of the systemic inflammatory response in patients with colorectal cancer. Br J Cancer. 2007 Nov 5;97 (9):1266-70. DOI: 10.1038/sj.bjc.6604027

13. Neal CP, Mann CD, Sutton CD, Garcea G, Ong SL, Steward WP, et al. Evaluation of the prognostic value of systemic inflammation and socioeconomic deprivation in patients with resectable colorectal liver metastases. Eur J Cancer. 2009 Jan;45 (1):56-64. DOI: 10.1016/j.ejca.2008.08.019

14. Rossi S, Basso M, Strippoli A, Schinzari G, D'Argento E, Laro-cca M, et al. Are Markers of Systemic Inflammation Good Prognostic Indicators in Colorectal Cancer? Clin Colorectal Cancer. 2017 Dec;16 (4):264-274. DOI: 10.1016/j.clcc.2017.03.015.

15. He W, Yin C, Guo G, Jiang C, Wang F, Qiu H, et al. Initial neutrophil lymphocyte ratio is superior to platelet lymphocyte ratio as an adverse prognostic and predictive factor in metastatic colorectal cancer. Med Oncol. 2013 Mar;30 (1):439. DOI: 10.1007/s12032-012-0439-x

16. Law WL, Choi HK, Lee YM, Ho JW. The Impact of Postoperative Complications on Long-Term Outcomes Following Curative Resection for Colorectal Cancer. Ann Surg Oncol. 2007 Sep;14 (9):2559-66. DOI: 10.1245/s10434-007-9434-4

17. Liu H, DU X, Sun P, Xiao C, Xu Y, Li R. Preoperative platelet-lymphocyte ratio is an independent prognostic factor for resectable colorectal cancer. Nan Fang Yi Ke Da Xue Xue Bao. 2013 Jan;33 (1):70-3.

18. Canna K, McArdle PA, McMillan DC, McNicol A-M, Smith GW, McKee RF, et al. The relationship between tumour T-lympho-cyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer. Br J Cancer. 2005 Feb 28;92 (4):651-4. DOI: 10.1038/sj.bjc.6602419

19. Yang J, Wezeman M, Zhang X, Lin P, Wang M, Qian J, et al. Human C-reactive protein binds activating Fcgamma receptors and protects myeloma tumor cells from apoptosis. Cancer Cell. 2007 Sep;12 (3):252-65. DOI: 10.1016/j.ccr.2007.08.008

20. Crozier JEM, McKee RF, McArdle CS, Angerson WJ, Anderson JH, Horgan PG, McMillan DC. Preoperative but not postoperative systemic inflammatory response correlates with survival in colorectal cancer. Br J Surg. 2007 Aug;94 (8):1028-32. DOI: 10.1002/bjs.5706

21. McArdle CS, McMillan DC, Hole DJ. Impact of anastomotic leakage on long-term survival of patients undergoing curative resection for colorectal cancer. Br J Surg. 2005 Sep;92 (9):1150-4. DOI: 10.1002/bjs.5054

22. Moyes LH, Leitch EF, McKee RF, Anderson JH, Horgan PG, McMillan DC. Preoperative systemic inflammation predicts postoperative infectious complications in patients undergoing curative resection for colorectal cancer. Br J Cancer. 2009 Apr 21;100 (8):1236-9. DOI: 10.1038/sj.bjc.6604997

23. Nozoe T, Matsumata T, Sugimachi K. Preoperative elevation of serum C-reactive protein is related to impaired immunity in patients with colorectal cancer. Am J Clin Oncol. 2000 Jun;23 (3):263-6.

24. Yffing H, Christensen IJ, Jensenius JC, Thiel S, Nielsen HJ. Preoperative mannan-binding lectin pathway and prognosis in colorectal cancer. Cancer Immunol Immunother. 2005 Mar;54 (3):265-72. DOI: 10.1007/s00262-004-0594-9

25. Moyes LH, Leitch EF, McKee RF, Anderson JH, Horgan PG, McMillan DC. Preoperative systemic inflammation predicts postoperative infectious complications in patients undergoing curative resection for colorectal cancer. Br J Cancer. 2009 Apr 21;100 (8):1236-9. DOI: 10.1038/sj.bjc.6604997

26. Tsujimoto H, Ueno H, Hashiguchi Y, Ono S, Ichikura T, Hase K. Postoperative infections are associated with adverse outcome after resection with curative intent for colorectal cancer. Oncol Lett. 2010 Jan;1 (1):119-125. DOI: 10.3892/ol_00000022

27. Mirnezami A, Mirnezami R, Chandrakumaran K, Sasapu K, Sagar P, Finan P. Increased Local Recurrence and Reduced Survival From Colorectal Cancer Following Anastomotic Leak. Ann Surg. 2011 May;253 (5):890-9. DOI: 10.1097/SLA.0b013e3182128929.

28. Eberhardt JM, Kiran RP, Lavery IC. The impact of anastomotic leak and intra-abdominal abscess on cancer-related outcomes after resection for colorectal cancer: a case control study. Dis Colon Rectum. 2009 Mar;52 (3):380-6. DOI: 10.1007/DCR.0b013e31819ad488

29. Lin J-K, Yueh T-C, Chang S-C, Lin C-C, Lan Y-T, Wang H-S, et al. The Influence of Fecal Diversion and Anastomotic Leakage on Survival after Resection of Rectal Cancer. J Gastrointest Surg. 2011 Dec;15 (12):2251-61. DOI: 10.1007/s11605-011-1721-5.

30. Eriksen MT, Wibe A, Norstein J, Haffner J, Wiig JN, Norwegian Rectal Cancer Group. Anastomotic leakage following routine mesorectal excision for rectal cancer in a national cohort of patients. Colorectal Dis. 2005 Jan;7 (1):51-7. DOI: 10.1111/j.1463-1318.2004.00700.x

31. den Dulk M, Marijnen CAM, Collette L, Putter H, Pahlman L, Folkesson J, et al. Multicentre analysis of oncological and survival outcomes following anastomotic leakage after rectal cancer surgery. Br J Surg. 2009 Sep;96 (9):1066-75. Doi: 10.1002/bjs.6694.

32. Espin E, Ciga MA, Pera M, Ortiz H, Spanish Rectal Cancer Project. Oncological outcome following anastomotic leak in rectal surgery. Br J Surg. 2015 Mar;102 (4):416-22. DOI: 10.1002/bjs.9748.

33. Pucher PH, Aggarwal R, Qurashi M, Darzi A. Meta-analysis of the effect of postoperative in-hospital morbidity on long-term patient survival. Br J Surg. 2014 Nov;101 (12):1499-508. DOI: 10.1002/bjs.9615.

34. McSorley ST, Horgan PG, McMillan DC. The impact of the type and severity of postoperative complications on longterm outcomes following surgery for colorectal cancer: A systematic review and meta-analysis. Crit Rev Oncol Hematol. 2016 Jan;97:168-77. DOI: 10.1016/j.critrevonc.2015.08.013.

35. Walker KG, Bell SW, Rickard MJFX, Mehanna D, Dent OF, Cha-puis PH, et al. Anastomotic leakage is predictive of diminished survival after potentially curative resection for colorectal cancer. Ann Surg. 2004 Aug;240 (2):255-9.

36. Artinyan A, Orcutt ST, Anaya DA, Richardson P, Chen GJ, Berger DH. Infectious Postoperative Complications Decrease Long-term Survival in Patients Undergoing Curative Surgery for Colorectal Cancer. Ann Surg. 2015 Mar;261 (3):497-505. DOI: 10.1097/SLA.0000000000000854

37. Tokunaga M, Tanizawa Y, Bando E, Kawamura T, Terashi-ma M. Poor survival rate in patients with postoperative intra-abdominal infectious complications following curative gastrectomy for gastric cancer. Ann Surg Oncol. 2013 May;20 (5):1575-83. DOI: 10.1245/s10434-012-2720-9

38. Andalib A, Ramana-Kumar AV, Bartlett G, Franco EL, Ferri LE. Influence of postoperative infectious complications on longterm survival of lung cancer patients: a population-based cohort study. J Thorac Oncol. 2013 May;8 (5):554-61. DOI: 10.1097/JTO.0b013e3182862e7e

39. Chia WK, Ali R, Toh HC. Aspirin as adjuvant therapy for colorectal cancer — reinterpreting paradigms. Nat Rev Clin Oncol. 2012 Oct;9 (10):561-70. DOI: 10.1038/nrclinonc.2012.137

40. Hur C, Simon LS, Gazelle GS. The cost-effectiveness of aspirin versus cyclooxygenase-2-selective inhibitors for colorectal carcinoma chemoprevention in healthy individuals. Cancer. 2004 Jul 1;101 (1):189-97.

41. Kryczek I, Lin Y, Nagarsheth N, Peng D, Zhao L, Zhao E, et al. IL-22+CD4+T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. Immunity. 2014;40 (5):772-84. DOI: 10.1002/cncr.20329

42. Spolarics Z, Siddiqi M, Siegel JH, Garcia ZC, Stein DS, Denny T, et al. Depressed interleukin-12-producing activity by monocytes correlates with adverse clinical course and a shift toward Th2-type lymphocyte pattern in severely injured male trauma patients. Crit Care Med. 2003 Jun;31 (6):1722-9. DOI: 10.1097/01.CCM.0000063579.43470.AA

43. Mokart D, Capo C, Blache JL, Delpero JR, Houvenaeghel G, Martin C, et al. Early postoperative compensatory anti-inflammatory response syndrome is associated with septic complications after major surgical trauma in patients with cancer. Br J Surg. 2002 Nov;89 (11):1450-6. DOI: 10.1046/j.1365-2168.2002.02218.x

44. Tsujimoto H, Ono S, Majima T, Efron PA, Kinoshita M, Hi-raide H, et al. Differential toll-like receptor expression after ex vivo lipopolysaccharide exposure in patients with sepsis and following surgical stress. Clin Immunol. 2006 May;119 (2):180-7. DOI: 10.1016/j.clim.2006.01.004

45. Clerici M, Shearer GM, Clerici E. Cytokine dysregulation in invasive cervical carcinoma and other human neoplasias: time to consider the TH1/TH2 paradigm. J Natl Cancer Inst. 1998 Feb 18;90 (4):261-3.

46. Mynster T, Christensen IJ, Moesgaard F, Nielsen HJ. Effects of the combination of blood transfusion and postoperative infectious complications on prognosis after surgery for colorectal cancer. Danish RANX05 Colorectal Cancer Study Group. Br J Surg. 2000 Nov;87 (11):1553-62. DOI: 10.1046/j.1365-2168.2000.01570.x

47. Stoian M, State N, Stoica V, Radulian G. Apoptosis in colorectal cancer. J Med Life. 2014 Jun 15;7 (2):160-4.

48. Bayhan Z, Simjek T, Ergul E, Utkan NZ, Canturk NZ, Cek-men M. Serum cytokine levels in patients with colorectal cancers according to tumor stages and VEGF gene polymorphism. Hepa-togastroenterology. 2014 Oct;61 (135):1889-94.

49. Terzi C, Unek T, Sagol O, Yilmaz T, Fuzun M, Sokmen S, et al. Is Rectal Washout Necessary in Anterior Resection for Rectal Cancer? A Prospective Clinical Study. World J Surg. 2006 Feb;30 (2):233—41. DOI: 10.1007/s00268-005-0300-x

50. Gertsch P, Baer HU, Kraft R, Maddern GJ, Altermatt HJ. Malignant cells are collected on circular staplers. Dis Colon Rectum. 1992 Mar;35 (3):238-41.

51. Fujita S, Teramoto T, Watanabe M, Kodaira S, Kitaji-ma M. Anastomotic leakage after colorectal cancer surgery: a risk factor for recurrence and poor prognosis. Jpn J Clin Oncol. 1993 Oct;23 (5):299-302.

52. Lee W-S, Yun SH, Roh Y-N, Yun H-R, Lee WY, Cho YB, et al. Risk Factors and Clinical Outcome for Anastomotic Leakage After Total Mesorectal Excision for Rectal Cancer. World J Surg. 2008 Jun;32 (6):1124-9. DOI: 10.1007/s00268-007-9451-2.


Для цитирования:


Гарманова Т.Н., Бредихин М.И., Тулина И.А., Царьков П.В. Роль воспаления в течении и лечении колоректального рака. Исследования и практика в медицине. 2018;5(4):36-45. https://doi.org/10.17709/2409-2231-2018-5-4-4

For citation:


Garmanova T.N., Bredikhin M.I., Tulina I.A., Tsarkov P.V. The role of inflammation in pathogenesis and treatment of colorectal cancer. Research'n Practical Medicine Journal. 2018;5(4):36-45. (In Russ.) https://doi.org/10.17709/2409-2231-2018-5-4-4

Просмотров: 146


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 2409-2231 (Print)
ISSN 2410-1893 (Online)