FIBROSCLEROSIS AND SCLEROSING ADENOSIS WITH MICROCALCIFICATIONS IN THE BREAST. MOLECULAR PATHOGENESIS, TIMELY DIAGNOSIS AND TREATMENT
E. L. Muyzhnek,
V. I. Kiselev,
O. E. Jakobs, 
N. I. Rozhkova,
A. D. Kaprin,
I. I. Burdina,
S. B. Zapirova,
M. L. Mazo,
S. P. Prokopenko,
P. G. Labazanova
N. I. Rozhkova,
A. D. Kaprin,
I. I. Burdina,
S. B. Zapirova,
M. L. Mazo,
S. P. Prokopenko,
P. G. Labazanova https://doi.org/10.17709/2409-2231-2019-6-2-8
Abstract
A brief review of current data on the generality of the epidemiology and molecular pathogenesis of breast cancer and benign breast diseases is presented. Currently, a type of mastopathy, fibrosclerosis/sclerosing adenosis, accompanied by the formation of microcalcifications, is considered as a benign pathological condition with a high risk of malignancy, and also as a pre-start condition of a possible transition of mastopathy to cancer. In the review is discussed the fundamental biological process of the epithelial-mesenchymal transition (EMT) as a molecular pathogenetic basis of this phenomenon. Identification of the above mentioned pathological changes using mammography and refined diagnostics using a vacuum aspiration biopsy allow timely treatment of fibrosclerosis and sclerosing adenosis with Indinol® Forto, a drug of pathogenetic action based on indole-3-carbinol, due to its multiple anticancer and oncoprophylactic activity, including ability to reverse at the epigenetic level the EMT process abnormally proceeding in these benign breast diseases.
About the Authors
E. L. Muyzhnek
Russian Scientific Center of Roentgen Radiology of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
PhD (in Biology), researcher of the research department for early carcinogenesis, prevention, diagnosis and comprehensive treatment of cancer of the female reproductive organs
86 Profsoyuznaya str., Moscow 117997
V. I. Kiselev
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology of the Ministry of Health of the Russian Federation,
Russian Federation
Russian Federation
Corr.member of RAS, MD, PhD, DSc (in Biology), Professor, Deputy Director for science, Academician
4 Akademika Oparina str., Moscow 117997
O. E. Jakobs
P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; Peoples’ Friendship University of Russia (RUDN University)
Russian Federation
MD, PhD, associate professor of the department of clinical mammology, radiology and radiotherapy of the faculty of advanced training of medical workers; senior researcher, department of comprehensive diagnostics and interventional radiology in mammology 3, 2nd Botkinskiy proezd, Moscow, 125284; 6 Miklukho-Maklaya str., Moscow 117198
Russian Federation
MD, PhD, associate professor of the department of clinical mammology, radiology and radiotherapy of the faculty of advanced training of medical workers; senior researcher, department of comprehensive diagnostics and interventional radiology in mammology 3, 2nd Botkinskiy proezd, Moscow, 125284; 6 Miklukho-Maklaya str., Moscow 117198
N. I. Rozhkova
P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; Peoples’ Friendship University of Russia (RUDN University)
Russian Federation
MD, PhD, DSc, Professor, Honored Scientist of the Russian Federation, Prize laureate of the USSR Council of Ministers, Head of the National Center for Oncology of the Reproductive Organs; Professor of the Department of Clinical Mammology, Radiology and Radiotherapy, Faculty of Advanced Training of Medical Workers 3, 2nd Botkinskiy proezd, Moscow, 125284; 6 Miklukho-Maklaya str., Moscow 117198
Russian Federation
MD, PhD, DSc, Professor, Honored Scientist of the Russian Federation, Prize laureate of the USSR Council of Ministers, Head of the National Center for Oncology of the Reproductive Organs; Professor of the Department of Clinical Mammology, Radiology and Radiotherapy, Faculty of Advanced Training of Medical Workers 3, 2nd Botkinskiy proezd, Moscow, 125284; 6 Miklukho-Maklaya str., Moscow 117198
A. D. Kaprin
Peoples’ Friendship University of Russia (RUDN University); National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
academician of RAS, PhD, MD, Prof.; Corr. member of the Russian Academy of Education; Honored Physician of the Russian Federation; General Director of National Medical Research Radiological Centre, Head of Department of Urology with Course of Urological Oncology, Faculty for Postgraduate Training, Peoples’ Friendship University of Russia
6 Miklukho-Maklaya str., Moscow 117198; 4 Koroleva str., Obninsk, Kaluga region, 249036
I. I. Burdina
P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
PhD, senior researcher, department of comprehensive diagnostics and interventional radiology in mammology
3, 2nd Botkinskiy proezd, Moscow, 125284
S. B. Zapirova
P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
MD, PhD, senior researcher, department of comprehensive diagnostics and interventional radiology in mammology
3, 2nd Botkinskiy proezd, Moscow, 125284
M. L. Mazo
P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; Peoples’ Friendship University of Russia (RUDN University)
Russian Federation
Mazo, MD, PhD, associate professor of the department of clinical mammology, radiology and radiotherapy of the faculty of advanced training of medical workers; senior researcher, department of comprehensive diagnostics and interventional radiology in mammology 3, 2nd Botkinskiy proezd, Moscow, 125284; 6 Miklukho-Maklaya str., Moscow 117198
Russian Federation
Mazo, MD, PhD, associate professor of the department of clinical mammology, radiology and radiotherapy of the faculty of advanced training of medical workers; senior researcher, department of comprehensive diagnostics and interventional radiology in mammology 3, 2nd Botkinskiy proezd, Moscow, 125284; 6 Miklukho-Maklaya str., Moscow 117198
S. P. Prokopenko
P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; Peoples’ Friendship University of Russia (RUDN University)
Russian Federation
Russian Federation
MD, PhD, head of the department of clinical mammology, radiology and radiotherapy of the faculty of advanced training of medical workers; head of department of comprehensive diagnostics and interventional radiology in mammology
3, 2nd Botkinskiy proezd, Moscow, 125284; 6 Miklukho-Maklaya str., Moscow 117198
P. G. Labazanova
P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
junior researcher, department of comprehensive diagnostics and interventional radiology in mammology
3, 2nd Botkinskiy proezd, Moscow, 125284
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For citations:
Muyzhnek E.L., Kiselev V.I., Jakobs O.E., Rozhkova N.I., Kaprin A.D., Burdina I.I., Zapirova S.B., Mazo M.L., Prokopenko S.P., Labazanova P.G. FIBROSCLEROSIS AND SCLEROSING ADENOSIS WITH MICROCALCIFICATIONS IN THE BREAST. MOLECULAR PATHOGENESIS, TIMELY DIAGNOSIS AND TREATMENT. Research and Practical Medicine Journal. 2019;6(2):75-85. (In Russ.) https://doi.org/10.17709/2409-2231-2019-6-2-8
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