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Expression of E- and N-cadherins in tumor in luminal, primary operable breast cancer without Her2/neu overexpression in postmenopausal women as a prognostic factor

https://doi.org/10.17709/2409-2231-2020-7-4-1

Abstract

Purpose of the study. Evaluation of the expression of E- and N-cadherins in tumor tissues in postmenopausal patients with primary operable luminal breast cancer (BC) without Her2/neu overexpression for inclusion in the panel of a comprehensive assessment of tumor biological parameters for the disease prognosis.

Patients and methods. The study included 120 patients divided into two groups: patients with luminal A and luminal B subtypes. To evaluate the prognostic significance of E- and N- cadherins in both groups of patients, we analyzed expression levels and correlation using the Mann- Whitney U-test and Spearman correlation criterion; overall survival, progression-free and tumor- specific one, at various values of the studied biomarkers — by the Kaplan- Meier method.

Results. The differences in the mean expression levels were not statistically significant (p>0,05). E-cadherin was twice higher in luminal A BC (55.4±5.2) compared to luminal B BC (28.1±4.9), N-cadherin in luminal A BC (12.8±5.3) was 1.3 times lower than in luminal B BC (17.06±5.4). Patients with luminal B BC demonstrated a tendency to the loss of E-cadherin and increased expression of N-cadherin, which is often associated with poor prognosis. However, the correlation between these markers was not statistically significant (p>0,05).

Conclusions. Thus, despite the differences in levels of E- and N-cadherin expression, these markers did not show their prognostic significance, and therefore, they were not included in the panel for a comprehensive assessment of tumor biological parameters when determining the prognosis of luminal breast cancer without Her2/neu overexpression in postmenopausal women.

About the Authors

V. V. Tokmakov
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation

Vasilii V. Tokmakov – oncologist

63 14 line str., Rostov-on-Don, 344037


Competing Interests:


E. P. Ulianova
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation

Elena P. Ulianova – researcher at the laboratory of tumor immunophenotyping

63 14 line str., Rostov-on-Don, 344037

SPIN: 1243-9475

AuthorID: 759154

Scopus Author ID: 57203357998



Yu. S. Shatova
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation

Yuliana S. Shatova – Dr. Sci. (Med.), oncologist 

63 14 line str., Rostov-on-Don, 344037

SPIN: 8503-3573

AuthorID: 294376

Scopus Author ID: 57200279683



A. B. Sagakyants
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation

Alexander B. Sagakyants – Cand. Sci. (Biol.), associate professor, head of the laboratory of tumor immunophenotyping 

63 14 line str., Rostov-on-Don, 344037

SPIN: 7272-1408

AuthorID: 426904

ResearcherID: M-8378-2019

Scopus Author ID: 24329773900



N. M. Mashchenko
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation

Natalia M. Mashchenko – leading specialist of the scientific and analytical Department National Medical Research Centre for Oncology of the Ministry of Health of Russia

63 14 line str., Rostov-on-Don, 344037

SPIN: 8650-5320

AuthorID: 564828

Scopus Author ID: 24329773900



I. A. Novikova
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation

Inna A. Novikova – Cand. Sci. (Med.), deputy director general for science National Medical Research Centre for Oncology of the Ministry of Health of Russia

63 14 line str., Rostov-on-Don, 344037

SPIN: 4810-2424

AuthorID: 726229

ResearcherID: E-7710-2018

Scopus Author ID: 7005153343


Competing Interests:


E. M. Nepomnyashchaya
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation

Evgeniya M. Nepomnyashchaya – Dr. Sci. (Med.), professor, pathologist 

63 14 line str., Rostov-on-Don, 344037

SPIN: 8930-9580

AuthorID: 519969



O. G. Shulgina
National Medical Research Centre for Oncology of the Ministry of Health of Russia
Russian Federation

Oksana G. Shulgina – junior researcher at the laboratory of tumor immunophenotyping 

63 14 line str., Rostov-on-Don, 344037

SPIN: 9668-3042

AuthorID: 886334


Competing Interests:


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Review

For citations:


Tokmakov V.V., Ulianova E.P., Shatova Yu.S., Sagakyants A.B., Mashchenko N.M., Novikova I.A., Nepomnyashchaya E.M., Shulgina O.G. Expression of E- and N-cadherins in tumor in luminal, primary operable breast cancer without Her2/neu overexpression in postmenopausal women as a prognostic factor. Research and Practical Medicine Journal. 2020;7(4):10-18. (In Russ.) https://doi.org/10.17709/2409-2231-2020-7-4-1

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ISSN 2410-1893 (Online)