Expression of E- and N-cadherins in tumor in luminal, primary operable breast cancer without Her2/neu overexpression in postmenopausal women as a prognostic factor
https://doi.org/10.17709/2409-2231-2020-7-4-1
Abstract
Purpose of the study. Evaluation of the expression of E- and N-cadherins in tumor tissues in postmenopausal patients with primary operable luminal breast cancer (BC) without Her2/neu overexpression for inclusion in the panel of a comprehensive assessment of tumor biological parameters for the disease prognosis.
Patients and methods. The study included 120 patients divided into two groups: patients with luminal A and luminal B subtypes. To evaluate the prognostic significance of E- and N- cadherins in both groups of patients, we analyzed expression levels and correlation using the Mann- Whitney U-test and Spearman correlation criterion; overall survival, progression-free and tumor- specific one, at various values of the studied biomarkers — by the Kaplan- Meier method.
Results. The differences in the mean expression levels were not statistically significant (p>0,05). E-cadherin was twice higher in luminal A BC (55.4±5.2) compared to luminal B BC (28.1±4.9), N-cadherin in luminal A BC (12.8±5.3) was 1.3 times lower than in luminal B BC (17.06±5.4). Patients with luminal B BC demonstrated a tendency to the loss of E-cadherin and increased expression of N-cadherin, which is often associated with poor prognosis. However, the correlation between these markers was not statistically significant (p>0,05).
Conclusions. Thus, despite the differences in levels of E- and N-cadherin expression, these markers did not show their prognostic significance, and therefore, they were not included in the panel for a comprehensive assessment of tumor biological parameters when determining the prognosis of luminal breast cancer without Her2/neu overexpression in postmenopausal women.About the Authors
V. V. TokmakovRussian Federation
Vasilii V. Tokmakov – oncologist
63 14 line str., Rostov-on-Don, 344037
Competing Interests: —
E. P. Ulianova
Russian Federation
Elena P. Ulianova – researcher at the laboratory of tumor immunophenotyping
63 14 line str., Rostov-on-Don, 344037
SPIN: 1243-9475
AuthorID: 759154
Scopus Author ID: 57203357998
Yu. S. Shatova
Russian Federation
Yuliana S. Shatova – Dr. Sci. (Med.), oncologist
63 14 line str., Rostov-on-Don, 344037
SPIN: 8503-3573
AuthorID: 294376
Scopus Author ID: 57200279683
A. B. Sagakyants
Russian Federation
Alexander B. Sagakyants – Cand. Sci. (Biol.), associate professor, head of the laboratory of tumor immunophenotyping
63 14 line str., Rostov-on-Don, 344037
SPIN: 7272-1408
AuthorID: 426904
ResearcherID: M-8378-2019
Scopus Author ID: 24329773900
N. M. Mashchenko
Russian Federation
Natalia M. Mashchenko – leading specialist of the scientific and analytical Department National Medical Research Centre for Oncology of the Ministry of Health of Russia
63 14 line str., Rostov-on-Don, 344037
SPIN: 8650-5320
AuthorID: 564828
Scopus Author ID: 24329773900
I. A. Novikova
Russian Federation
Inna A. Novikova – Cand. Sci. (Med.), deputy director general for science National Medical Research Centre for Oncology of the Ministry of Health of Russia
63 14 line str., Rostov-on-Don, 344037
SPIN: 4810-2424
AuthorID: 726229
ResearcherID: E-7710-2018
Scopus Author ID: 7005153343
Competing Interests:
E. M. Nepomnyashchaya
Russian Federation
Evgeniya M. Nepomnyashchaya – Dr. Sci. (Med.), professor, pathologist
63 14 line str., Rostov-on-Don, 344037
SPIN: 8930-9580
AuthorID: 519969
O. G. Shulgina
Russian Federation
Oksana G. Shulgina – junior researcher at the laboratory of tumor immunophenotyping
63 14 line str., Rostov-on-Don, 344037
SPIN: 9668-3042
AuthorID: 886334
Competing Interests:
References
1. Paltuev RM. Biological rationale for a patient-specific approach in the treatment of breast cancer. Clinical value of novel biomarkers of breast cancer. Tumors of the Female Reproductive System. 2019;15(2):10–29. (In Russian). https://doi.org/10.17650/1994-4098-2019-15-2-10-29
2. Kit OI, Shatova YuS, Tokmakov VV, Novikova IA, Ul'yanova EP, Zlatnik EYu. Expression level of androgen receptors in tumor tissue and its prognostic significance in primary operable luminal breast cancer without overexpression of Her2/neu in postmenopausal women. Kazan Medical Journal. (In Russian). 2019;100(1):112–116. https://doi.org/10.17816/KMJ2019-112
3. Matsunaga E, Okanoya K. Cadherins: potential regulators in the faculty of language. Curr Opin Neurobiol. 2014 Oct;28:28–33. https://doi.org/10.1016/j.conb.2014.06.001
4. van Roy F, Berx G. The cell-cell adhesion molecule E-cadherin. Cell Mol Life Sci. 2008 Nov;65(23):3756–3788. https://doi.org/10.1007/s00018-008-8281-1
5. Schmalhofer O, Brabletz S, Brabletz T. E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer. Cancer Metastasis Rev. 2009 Jun;28(1–2):151–166. https://doi.org/10.1007/s10555-008-9179-y
6. Beeghly-Fadiel A, Lu W, Gao Y-T, Long J, Deming SL, Cai Q, et al. E-cadherin polymorphisms and breast cancer susceptibility: a report from the Shanghai Breast Cancer Study. Breast Cancer Res Treat. 2010 Jun;121(2):445–452. https://doi.org/10.1007/s10549-009-0579-7
7. Kourtidis A, Lu R, Pence LJ, Anastasiadis PZ. A central role for cadherin signaling in cancer. Exp Cell Res. 2017 Sep 1;358(1):78–85. https://doi.org/10.1016/j.yexcr.2017.04.006
8. Puchinskaya MV. Epithelial-mesenchymal transition in health and disease. Arkhiv Patologii. 2015;77(1):75–83. (In Russian). https://doi.org/10.17116/patol201577175
9. Thiery JP, Sleeman JP. Complex networks or chestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol. 2006 Feb;7(2):131–142. https://doi.org/10.1038/nrm1835
10. de Deus MR, Wludarski SC, Carvalho FM, Bacchi CE. Immunohistochemistry applied to the differential diagnosis between ductal and lobular carcinoma of the breast. Appl Immunohistochem Mol Morphol. 2013 Jan;21:1–12. https://doi.org/10.1097/pai.0b013e318255bafa
11. Ionescu Popescu C, Giuşcă SE, Liliac L, Avadanei R, Ceauşu R, Cîmpean AM, et al. E-cadherin expression in molecular types of breastcarcinoma. Rom J Morphol Embryol. 2013;54(2):267–273.
12. Becker SF, Langhe R, Huang C, Wedlich D, Kashef J. Giving the right tug for migration: cadherins in tissue movements. Arch Biochem Biophys. 2012 Aug 1;524(1):30–42. https://doi.org/10.1016/j.abb.2012.02.013
13. Park KS, Dubon MJ, Gumbiner BM. N-cadherin mediates the migration of MCF-10A cells undergoing bone morphogenetic protein 4-mediated epithelial mesenchymal transition. Tumour Biol. 2015 May;36(5):3549–3556. https://doi.org/10.1007/s13277-014-2991-9
14. Nagi C, Guttman M, Jaffer S, Qiao R, Keren R, Triana A, et al. N-cadherin expression in breast cancer: correlation with an aggressive histologic variant-invasive micropapillary carcinoma. Breast Cancer Res Treat. 2005 Dec;94(3):225–235. https://doi.org/10.1007/s10549-005-7727-5
15. Zasadkevich YuM, Brilliant AA, Sazonov SV. Role of cadherins in health and in developing breast cancer. Arkhiv Patologii. 2015;77(3):57–64. (In Russian). https://doi.org/10.17116/patol201577357-64
Review
For citations:
Tokmakov V.V., Ulianova E.P., Shatova Yu.S., Sagakyants A.B., Mashchenko N.M., Novikova I.A., Nepomnyashchaya E.M., Shulgina O.G. Expression of E- and N-cadherins in tumor in luminal, primary operable breast cancer without Her2/neu overexpression in postmenopausal women as a prognostic factor. Research and Practical Medicine Journal. 2020;7(4):10-18. (In Russ.) https://doi.org/10.17709/2409-2231-2020-7-4-1