Human pluripotent stem cells in contemporary medicine
https://doi.org/10.17709/2409-2231-2015-2-2-44-52
Abstract
Human pluripotent stem cells (hPSCs) are capable of indefinite proliferation and can be differentiated into any cell type of the human body. Therefore, they are a promising source of cells for treatment of numerous degenerative diseases and injuries. Pluripotent stem cells are also associated with a number of ethical, safety and technological issues. In this review, we describe various types of hPSCs, safety issues that concern all or some types of hPSCs and methods of clinical-grade hPSC line development. Also, we discuss current and past clinical trials involving hPSCs, their outcomes and future perspectives of hPSC-based therapy.
About the Author
S. A. Rodin
Division of Matrix Biology Department of Medical Biochemistry and Biophysics Karolinska Institutet, Stockholm
Scheelesvag 2, Plan 4:B1, 17177 Stockholm
Russian Federation
Russian Federation
PhD, senior researcher of Division of Matrix Biology Department of Medical Biochemistry and Biophysics Karolinska Institutet
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Review
For citations:
Rodin S.A. Human pluripotent stem cells in contemporary medicine. Research and Practical Medicine Journal. 2015;2(2):44-52. (In Russ.) https://doi.org/10.17709/2409-2231-2015-2-2-44-52
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