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Research'n Practical Medicine Journal

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Возможности химиотерапии у больных местно-распространенным и метастатическим аденогенным раком поджелудочной железы

https://doi.org/10.17709/2409-2231-2020-7-4-10

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Аннотация

В настоящее время рак поджелудочной железы остается одной из наиболее неблагоприятных опухолевых патологий, характеризующейся выраженными сложностями диагностики и лечения, значительным влиянием на трудоспособность и качество жизни больных, низкими показателями продолжительности жизни пациентов. Особенности развития злокачественных новообразований данной локализации способствуют ограничению возможности выполнения радикального оперативного вмешательства, в связи с чем особая роль в лечении больных раком поджелудочной железы отводится химиотерапии. Специфическая системная лекарственная терапия при данной патологии является важнейшим и, в преобладающем числе случаев, обязательным элементом лечения. Она может осуществляться в неоадъювантном, адъювантном и самостоятельном режиме, включать моно- или поликомпонентные схемы, а также сочетаться с другими видами системного или локального противоопухолевого воздействия. Выбор режима химиотерапии зависит в первую очередь от общего соматического статуса пациента и определяется потенциальной токсичностью той или иной комбинации цитостатиков. В данном обзоре литературы продемонстрирована эффективность применения различных схем химиотерапии у больных раком поджелудочной железы III–IV стадии в рамках первой и второй линии, описаны частота возникновения нежелательных реакций на лечение и их характер, упомянуты пути снижения степени токсичности поликомпонентных режимов лекарственной терапии. Данный обзор выполнен на основании анализа научных источников интернет-ресурса «National Center for Biotechnological Information».

Об авторах

Л. И. Москвичева
МНИОИ им. П.А.Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации
Россия

Москвичева Людмила Ивановна – врач-онколог кабинета ультразвуковой диагностики и терапии

125284, г. Москва, 2-й Боткинский проезд, д. 3

SPIN: 8321-3464

AuthorID: 861695



Л. В. Болотина
МНИОИ им. П.А.Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации
Россия

Болотина Лариса Владимировна - д.м.н., заведующая отделением химиотерапии

125284, г. Москва, 2-й Боткинский проезд, д. 3

SPIN: 2787-5414

AuthorID: 594953



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Для цитирования:


Москвичева Л.И., Болотина Л.В. Возможности химиотерапии у больных местно-распространенным и метастатическим аденогенным раком поджелудочной железы. Research'n Practical Medicine Journal. 2020;7(4):118-134. https://doi.org/10.17709/2409-2231-2020-7-4-10

For citation:


Moskvicheva L.I., Bolotina L.V. Possibilities of palliative chemotherapy in patients with locally advanced and metastatic pancreatic cancer. Research and Practical Medicine Journal. 2020;7(4):118-134. (In Russ.) https://doi.org/10.17709/2409-2231-2020-7-4-10

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ISSN 2410-1893 (Online)