PHOTOTHERAPY AND PHOTODYNAMIC THERAPY IN THE TREATMENT OF EXTRAGENITAL LICHEN SCLEROSUS
https://doi.org/10.17709/2409-2231-2015-2-3-51-58
Abstract
Abstract:
Lichen sclerosus is a chronic inflammatory disease of the skin and mucous membranes coated with squamous nonkeratinizing epithelium. The etiology of this disease is not completely clear. The exact prevalence of the disease is quite difficult to establish due to a lack of awareness of medical staff about the disease and relatively few patients visit medical specialists. Many researchers lean towards autoimmune theory of the origin of the disease. This is the basis for the most common methods of treatment. We have the information that lichen sclerosus may be caused by trauma, hormonal disorders and infectious lesions. In some cases genetic predisposition is observed. Standard treatment for lichen sclerosus is the topical application of glucocorticosteroids. If this treatment is ineffective topical calcineurin inhibitors are used. However, in many cases both treatments of lichen sclerosus are ineffective. In response to the problem alternative therapies can be used. Efficiency of phototherapy and photodynamic therapy for some cutaneous diseases is well known, in this regard it is important to examine in depth possibilities of these methods for treatment of lichen sclerosus.
About the Authors
O. O. KatzRussian Federation
student of 5th course of medical faculty, INPE MEPhI
F. A. Trifonov
Russian Federation
student of 6th course of medical faculty, INPE MEPhI
V. V. Kuznetsov
Russian Federation
Ph.D., associate professor, head of practice of students and graduates, INPE MEPhI
References
1. Kizer W. S., Prarie T., Morey A. F. Balanitis xerotica obliterans: epidemiologic distribution in an equal access health care system. South Med J. 2003; 96 (1): 9–11.
2. Wallace H. J. Lichen sclerosus et atrophicus. Trans St Johns Hosp Dermatol Soc. 1971; 57 (1): 9–30.
3. Brown A. R., Dunlap C. L., Bussard D. A., Lask J. T. Lichen sclerosus et atrophicus of the oral cavity: report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997; 84 (2): 165–170.
4. Kreuter A., Kryvosheyeva Y., Terras S., Moritz R., et al. Association of autoimmune diseases with lichen sclerosus in 532 male and female patients. Acta Derm Venereol. 2013; 93 (2): 238–241.
5. Goldstein A. T., Marinoff S. C., Christopher K., Srodon M. Prevalence of vulvar lichen sclerosus in a general gynecology practice. J Reprod Med. 2005; 50 (7): 477–480.
6. Powell J., Wojnarowska F. Childhood vulvar lichen sclerosus: an increasingly common problem. J Am Acad Dermatol. 2001; 44 (5): 803–806.
7. Guerriero C., Manco S., Paradisi A., et al. Extragenital lichen sclerosus and atrophicus treated with topical steroids and retinoids in a child with vitiligo. Int J Immunopathol Pharmacol. 2008; 21 (3): 757–759.
8. Padmavathy L., Lakshmana Rao L., Dhana Lakshmi M., et al. Lichen Sclerosus Atrophicus [LSA] in the Areolae: A Case Report. Case Rep Dermatol Med. 2012;2012:825963. doi: 10.1155/2012/825963.
9. Kim Y. J., Lee E. S. Case of sequentially occurring lesions of facial lichen sclerosus following the lines of Blaschko. J Dermatol. 2007; 34 (3): 201–204.
10. Happle R., Assim A. The lines of Blaschko on the head and neck. J Am Acad Dermatol. 2001; 44 (4): 612–615.
11. 11. Kaur S., Thami G. P., Kanwar A. J., Mohan H. Linear oro-facial lichen sclerosus. Clin Exp Dermatol. 2002; 27 (6): 467–470.
12. Walsh S. N., Jorizzo J. L., Haverstock C., Sangüeza O. P. A linear orofacial macule. Am J Dermatopathol. 2008; 30 (2): 194–195.
13. Izumi T., Tajima S. A case of linear type of lichen sclerosus et atrophicus? J Dermatol. 1995; 22 (4): 279–282.
14. Ajayi O., Stephens J. C., Karim S., Daly N. Lichen sclerosis et atrophicus masquerading as tonsillar squamous cell carcinoma. J Laryngol Otol. 2009; 123 (2): 10.
15. Khatu S., Vasani R. Isolated, localised extragenital bullous lichen sclerosus et atrophicus: a rare entity. Indian J Dermatol. 2013; 58 (5): 409.
16. Corbalán-Vélez R., Pérez-Ferriols A. Lichen sclerosus et atrophicus affecting the wrists and left ankle and clinically simulating lichen planus. Cutis. 2001; 67 (5): 417–419.
17. Kaplan M. A., Romanko Yu. S. Lazernaya fotodinamicheskaya terapiya (obzor, sostoyanie problemy i perspektivy). Fizioterapiya, bal’neologiya i reabilitatsiya. 2004; 1: 43–48.
18. Filonenko E. V. Flyuorestsentnaya diagnostika i fotodinamicheskaya terapiya — obosnovanie primeneniya i vozmozhnosti v onkologii. Fotodinamicheskaya terapiya i fotodiagnostika. 2014;1: 3–7. (Russian)
19. Tsyb A. F., Kaplan M. A., Romanko Yu. S., Popuchiev V. V. Klinicheskie aspekty fotodinamicheskoi terapii. Kaluga: Izdatel’stvo nauchnoi literatury N. F. Bochkarevoi, 2009. (Russian)
20. Korenev S. V., Vaisbein I. Z., Popuchiev V. V., Romanko Yu. S. Primenenie flyuorestsentnoi diagnostiki v opredelenii taktiki lecheniya raka vul’vy.//Sbornik nauchnykh rabot Mezhdunarodnoi nauchno-prakticheskoi konferentsii “Sovremennye tekhnologii akusherstva i ginekologii v reshenii problem demograficheskoi bezopasnosti”. Kaliningrad. 2014. s.69–72. (Russian)
21. Korenev S. V., Romanko Yu. S. Vozmozhnosti fotodinamicheskoi terapii pri rake vul’vy.//Sbornik nauchnykh rabot Mezhdunarodnoi nauchno-prakticheskoi konferentsii “Sovremennye tekhnologii akusherstva i ginekologii v reshenii problem demograficheskoi bezopasnosti”. Kaliningrad. 2014. s.72–76. (Russian)
22. Filonenko E. V., Chulkova O. V., Novikova E. G. i dr. Fotodinamicheskaya terapiya raka vul’vy. Fotodinamicheskaya terapiya i fotodiagnostika. 2014; 1: 49–50. (Russian).
23. Galkin V. N., Kaplan M. A., Ragulin Yu. A. i dr. Sanatsionnaya bronkhoskopiya posle fotodinamicheskoi terapii v kombinirovannom lechenii raka legkogo.//Sbornik nauchnykh rabot VI Vserossiiskoi nauchno-prakticheskoi konferentsii s mezhdunarodnym uchastiem “Aktual’nye voprosy endoskopii. Sovremennye vozmozhnosti endoskopii v diagnostike i lechenii vzroslykh i detei”. Sankt-Peterburg. 2015. s.135–136. (Russian)
24. Filonenko E. V., Sokolov V. V., Karpova E. S. Effektivnost’ fotodinamicheskoi terapii pri lechenii bol’nykh rannim rakom zheludka. Fotodinamicheskaya terapiya i fotodiagnostika. 2013; 2: 3–6. (Russian)
25. Chernyshev I. V., Altunin D. V., Samsonov Yu. V., Kallaev K. K. Novye vozmozhnosti fotodinamicheskoi diagnostiki i lecheniya raka predstatel’noi zhelezy i pochki. (Russian). Eksperimental’naya i klinicheskaya urologiya. 2011; 2–3: 92–94.
26. Filonenko E. V., Kaprin A. D., Alekseev B.Ya., Urlova A. N. Klinicheskoe nablyudenie uspeshnoi fotodinamicheskoi terapii bol’nogo s eritroplaziei Keira. Fotodinamicheskaya terapiya i fotodiagnostika. 2014; 2: 28–30. (Russian)
27. Chernyshev I. V., Altunin D. V., Samsonov Yu. V., Osipov O. V. Fotodinamicheskaya terapiya v kombinirovannom lechenii poverkhnostnogo raka mochevogo puzyrya. Nauchno-meditsinskii vestnik Tsentral’nogo Chernozem’ya. 2008; 34: 60–61. (Russian)
28. Romanko Yu. S., Kaplan M. A., Popuchiev V. V. i dr. Fotodinamicheskaya terapiya revmatoidnogo artrita. Radiatsiya i risk. 2014; 23 (1): 66–77. (Russian)
29. Molochkov V. A., Romanko Yu. S., Popuchiev V. V. i dr. Vliyanie fotodinamicheskoi terapii s fotoditazinom na morfofunktsional’nye kharakteristiki sarkomy M‑1. Rossiiskii zhurnal kozhnykh i venericheskikh boleznei. 2005; 5: 58–63. (Russian)
30. Sukhova T. E., Molochkov V. A., Romanko Yu. S. i dr. Lechenie bazal’nokletochnogo raka kozhi na sovremennom etape. Al’manakh klinicheskoi meditsiny. 2008; 18: 14–21. (Russian)
31. Kaplan M. A., Kapinus V. N., Romanko Yu. S., Yaroslavtseva-Isaeva E. V. Fotoditazin — effektivnyi fotosensibilizator dlya fotodinamicheskoi terapii. Rossiiskii bioterapevticheskii zhurnal. 2004; 3 (2): 50. (Russian)
32. Kaplan M. A., Romanko Yu. S., Popuchiev V. V. i dr. Vliyanie plotnosti svetovoi energii na protivoopukholevuyu effektivnost’ fotodinamicheskoi terapii s fotoditazinom. Lazernaya meditsina. 2005; 9 (2): 46–54. (Russian)
33. Romanko Yu. S., Tsyb A. F., Kaplan M. A., Popuchiev V. V. Effect of photodynamic therapy with photodithazine on morphofunctional parameters of M‑1 sarcoma/Bulletin of Experimental Biology and Medicine. 2004; 138 (6): 584–589. (Russian)
34. Romanko Yu. S., Tsyb A. F., Kaplan M. A., Popuchiev V. V. Relationship between antitumor efficiency of photodynamic therapy with photoditasine and photoenergy density/Bulletin of Experimental Biology and Medicine. 2005; 139 (4): 460–464. (Russian)
35. Kaplan M. A., Romanko Yu. S., Popuchiev V. V. i dr. Deistvie fotodinamicheskoi terapii na rost i funktsional’nuyu morfologiyu sarkomy M‑1. Lazernaya meditsina. 2005; 9 (4): 41–47. (Russian)
36. Romanko Yu. S. Fotodinamicheskaya terapiya bazal’nokletochnogo raka kozhi (eksperimental’no-klinicheskoe issledovanie): Avtroref. dis. … dokt. med. nauk: 14.00.19/Med. rad. nauch. tsentr. Obninsk. 2005. (Russian)
37. Romanko Yu. S., Tsyb A. F., Kaplan M. A., Popuchiev V. V. Zavisimost’ protivoopukholevoi effektivnosti fotodinamicheskoi terapii ot plotnosti svetovoi energii. Byulleten’ eksperimental’noi biologii i meditsiny. 2005; 139 (4) 456–461. (Russian)
38. Kaplan M. A., Kapinus V. N., Popuchiev V. V. i dr. Fotodinamicheskaya terapiya: rezul’taty i perspektivy. Radiatsiya i risk. 2013; 22 (3): 115–123. (Russian)
39. Tsyb A. F., Kaplan M. A., Molochkov V. A. i dr. O primenenii fotodinamicheskoi terapii v lechenii solitarnykh i mnozhestvennykh bazaliom. Rossiiskii zhurnal kozhnykh i venericheskikh boleznei. 2000; 4: 4–12. (Russian)
40. Yaroslavtseva-Isaeva E. V., Kaplan M. A., Romanko Yu. S., Sokol N. I. Razrabotka metodiki fotodinamicheskoi terapii eksperimental’noi opukholi (sarkoma M‑1) pri lokal’nom vvedenii fotosensibilizatora. Rossiiskii bioterapevticheskii zhurnal. 2003; 2 (4): 19–22. (Russian)
41. Taranets T. A., Sukhova T. E., Romanko Yu. S. Fotodinamicheskaya terapiya bazal’no-kletochnogo raka kozhi s lokal’nym i vnutrivennym ispol’zovaniem fotosensibilizatora khlorinovogo ryada «Fotolon». Al’manakh klinicheskoi meditsiny. 2007;15: 283–288. (Russian)
42. Sukhova T. E., Romanko Yu. S., Matveeva O. V. Fotodinamicheskaya terapii bazal’no-kletochnogo raka kozhi s lokal’nym primeneniem radakhlorina. Rossiiskii zhurnal kozhnykh i venericheskikh boleznei. 2008; 4: 41–44. (Russian)
43. Sukhova T. E., Molochkov V. A., Romanko Yu. S. i dr. Fotodinamicheskaya terapiya aktinicheskogo keratoza s applikatsionnym primeneniem «Fotoditazina». Rossiiskii zhurnal kozhnykh i venericheskikh boleznei. 2010; 5: 4–8. (Russian)
44. Sukhova T. E., Romanko Yu. S., Molochkov A. V., Tret’yakova E. I. K topicheskoi fotodinamicheskoi terapii bazal’no-kletochnogo raka kozhi.//Sbornik nauchnykh rabot Nauchno-prakticheskoi konferentsii dermatovenerologov Tsentral’nogo federal’nogo okruga RF “Aktual’nye voprosy dermatovenerologii i dermatoonkologii”. Moskva. 2011. c. 60–65. (Russian)
45. Molochkov V. A., Molochkov A. V., Sukhova T. E. i dr. Mestnaya fotodinamicheskaya terapiya keratoakantomy. Rossiiskii zhurnal kozhnykh i venericheskikh boleznei. 2012; 4: 21–24. (Russian)
46. Molochkov A. V., Romanko Yu. S., Kazantseva K. V. i dr. Lazeroindutsirovannaya termoterapiya i fotodinamicheskaya terapiya v dermatologii: vozmozhnosti i perspektivy. Al’manakh klinicheskoi meditsiny. 2014; 34: 30–35. (Russian)
47. Molochkov A. V., Kaprin A. D., Galkin V. N. i dr. Lechenie bazal’nokletochnoi kartsinomy s ispol’zovaniem fotodinamicheskoi terapii i lokal’nym primeneniem fotosensibilizatora fotolon. Radiatsiya i risk. 2015; 24 (1): 108–117. (Russian)
48. Romanko Yu. S., Kaplan M. A., Popuchiev V. V. Mekhanizmy deistviya fotodinamicheskoi terapii s fotoditazinom na sarkomu M‑1. Lazernaya meditsina. 2004; 8 (3) 232. (Russian)
49. Tsyb A. F., Kaplan M. A., Romanko Yu. S., Popuchiev V. V. Fotodinamicheskaya terapiya. M.: MIA, 2009. (Russian)
50. Kapinus V. K., Romanko Yu. S., Kaplan M. A. i dr. Effektivnost’flyuorestsentnoi diagnostiki i fotodinamicheskoi terapii s fotosensibilizatorom fotoditazin u bol’nykh rakom kozhi. Rossiiskii bioterapevticheskii zhurnal. 2005; 4 (3): 69–75. (Russian)
51. Kaplan M. A., Romanko Yu. S., Mardynskaya V. P. i dr. Razrabotka metoda fotodinamicheskoi terapii s fotoditazinom u eksperimental’nykh zhivotnykh s sarkomoi M‑1. Rossiiskii bioterapevticheskii zhurnal. 2004; 3 (2): 52. (Russian)
52. Romanko Yu. S., Korenev S. V., Popuchiev V. V. i dr. Osnovy fotodinamicheskoi terapii. Kaliningrad: Strazh Baltiki, 2010. (Russian)
53. Volgin V. N., Stranadko E. F., Trishkina O. V. i dr. Sravnitel’naya kharakteristika razlichnykh vidov lecheniya bazal’no-kletochnogo raka kozhi. Rossiiskii zhurnal kozhnykh i venericheskikh boleznei. 2013; 5: 4–10. (Russian)
54. Katsalap S. N., Romanko Yu. S. Vybor varianta fotodinamicheskoi terapii retsidivnoi bazaliomy. Vestnik esteticheskoi meditsiny. 2012; 11 (1): 44–48. (Russian)
55. Kaplan M. A., Romanko Yu. S., Popuchiev V. V. Atlas fotodinamicheskoi terapii. M.: Littera, 2015. (Russian)
56. Kazantseva K. V., Molochkov A. V., Molochkov V. A. i dr.. Sarkoma Kaposhi: patogenez, klinika, diagnostika i sovremennye printsipy lecheniya. Rossiiskii zhurnal kozhnykh i venericheskikh boleznei. 2015; 1: 4–12. (Russian)
57. Sukhova T. E., Romanko Yu. S., Yaroslavtseva-Isaeva E. V. i dr. Vnutritkanevoi variant vvedeniya fotosensibilizatora pri fotodinamicheskoi terapii bazal’no-kletochnogo raka kozhi (soobshchenie 1). Rossiiskii zhurnal kozhnykh i venericheskikh boleznei. 2010; 2: 4–10. (Russian)
58. Molochkov A. V., Sukhova T. E., Tret’yakova E. I. i dr. Sravnitel’nye rezul’taty effektivnosti lazeroindutsirovannoi termoterapii i fotodinamicheskoi terapii poverkhnostnoi i mikronodulyarnoi bazaliom. Rossiiskii zhurnal kozhnykh i venericheskikh boleznei. 2012; 4: 30–36. (Russian)
59. Von Kobyletzki G., Freitag M., Hoffmann K., et al. Balneophotochemotherapy with 8‑methoxypsoralen in lichen sclerosis et atrophicus. Hautarzt. 1997; 48 (7); 488–491.
60. Dalmau J., Baselga E., Roé E., Alomar A. Psoralen-UVA treatment for generalized prepubertal extragenital lichen sclerosus et atrophicus. J Am Acad Dermatol. 2006;55 (2): 56–58.
61. Valdivielso-Ramos M., Bueno C., Hernanz J. M. Significant improvement in extensive lichen sclerosus with tacrolimus ointment and PUVA. Am J Clin Dermatol. 2008; 9 (3) 175–179.
62. Kreuter A., Gambichler T., Avermaete A., Happe M., et al. Lowdose ultraviolet A1 phototherapy for extragenital lichen sclerosus: results of a preliminary study. J Am Acad Dermatol. 2002; 46 (2): 251–255.
63. Colbert R. L., Chiang M. P., Carlin C. S., Fleming M. Progressive extragenital lichen sclerosus successfully treated with narrowband UV-B phototherapy. Arch Dermatol. 2007; 143 (1): 19–20.
64. Greve B., Hartschuh W., Raulin C. Extragenital lichen sclerosus et atrophicus — treatment with pulsed dye laser. Hautarzt. 1999;50 (11): 805–808.
65. Passeron T., Lacour J. P., Ortonne J. P. Comparative treatment of extragenital lichen sclerosus with methylaminolevulinic Acid pulsed dye laser-mediated photodynamic therapy or pulsed dye laser alone. Dermatol Surg. 2009; 35 (5): 878–880.
66. Reichrath J., Reinhold U., Tilgen W. Treatment of genito-anal lesions in inflammatory skin diseases with PUVA cream photochemotherapy: an open pilot study in 12 patients. Dermatology. 2002; 205 (3): 245–248.
67. Beattie P. E., Dawe R. S., Ferguson J., Ibbotson S. H. UVA1 phototherapy for genital lichen sclerosus. Clin Exp Dermatol. 2006; 31 (3): 343–347.
68. Hillemanns P., Untch M., Pröve F., et al. Photodynamic therapy of vulvar lichen sclerosus with 5‑aminolevulinic acid. Obstet Gynecol. 1999; 93 (1) 71–74.
69. Olejek A., Steplewska K., Gabriel A., et al. Efficacy of photodynamic therapy in vulvar lichen sclerosus treatment based on immunohistochemical analysis of CD34, CD44, myelin basic protein, and Ki67 antibodies. Int J Gynecol Cancer. 2010; 20 (5): 879–887.
70. Manolova G., Pehlivanov G., Bakardzhiev I., et al. Lichen sclerosus -clinical and therapeutic aspects. Akush Ginekol. 2014; 53 (1) 35–39.
Review
For citations:
Katz O.O., Trifonov F.A., Kuznetsov V.V. PHOTOTHERAPY AND PHOTODYNAMIC THERAPY IN THE TREATMENT OF EXTRAGENITAL LICHEN SCLEROSUS. Research and Practical Medicine Journal. 2015;2(3):51-58. (In Russ.) https://doi.org/10.17709/2409-2231-2015-2-3-51-58