Treatment of HER2/neu-positive breast cancer with brain metastases: a clinical case

G. V. Afonin; A. E. Glukhareva; E. I. Kupriyanova; A. A. Sofiychuk; А. S. Belokhvostova; N. A. Falaleeva; S. A. Ivanov; A. D. Kaprin

Research and Practical Medicine Journal
Issledovaniâ i praktika v medicine.

ISSN 2410-1893 (Online)

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Afonin G.V., Glukhareva A.E., Kupriyanova E.I., Sofiychuk A.A., Belokhvostova А.S., Falaleeva N.A., Ivanov S.A., Kaprin A.D. Treatment of HER2/neu-positive breast cancer with brain metastases: a clinical case. Research and Practical Medicine Journal. 2026;13(2):131-139. (In Russ.) https://doi.org/10.17709/2410-1893-2026-13-2-10. EDN: TGZWDS

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ISSN 2410-1893 (Online)

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About the Authors

G. V. Afonin
https://new.nmicr.ru/mrrc/
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre Obninsk, Russian Federation

Grigoriy V. Afonin – Cand. Sci. (Medicine), Head of the Department of Thoracic Oncology, A.Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Obninsk, Russian Federation

ORCID: https://orcid.org/0000-0002-7128-2397, eLibrary SPIN: 9039-6110, AuthorID: 896307, Scopus Author ID: 57204696417, WoS ResearcherID: О-3150-2017

A. E. Glukhareva
https://new.nmicr.ru/mrrc/
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre Obninsk, Russian Federation

Anastasia E. Glukhareva – oncologist, Department of Thoracic Oncology, A.Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Obninsk, Russian Federation

ORCID: https://orcid.org/0000-0002-4122-1569, eLibrary SPIN: 6093-0578, AuthorID: 1069449

E. I. Kupriyanova
https://new.nmicr.ru/mrrc/
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre Obninsk, Russian Federation

Ekaterina I. Kupriyanova – pathologist, Department of Pathology, A.Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Obninsk, Russian Federation

ORCID: https://orcid.org/0000-0001-5856-9759, eLibrary SPIN: 3557-2386, AuthorID: 919978

A. A. Sofiychuk
https://new.nmicr.ru/mrrc/
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre Obninsk, Russian Federation

Alexander A. Sofiychuk – oncologist, Department of Anticancer Drug Therapy, A.Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Obninsk, Russian Federation

ORCID: https://orcid.org/0009-0008-0769-1736

А. S. Belokhvostova
https://new.nmicr.ru/mrrc/
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre Obninsk, Russian Federation

Аnna S. Belokhvostova – Cand. Sci. (Medicine), Head of the Department of Anticancer Drug Therapy, A.Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Obninsk, Russian Federation

ORCID: https://orcid.org/0000-0002-4709-1726

N. A. Falaleeva
https://new.nmicr.ru/mrrc/
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre Obninsk, Russian Federation

Natalia A. Falaleeva – Dr. Sci. (Medicine), Head of the Department of Drug Treatment of Malignant Neoplasms, A.Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Obninsk, Russian Federation

ORCID: https://orcid.org/0000-0002-0023-4216, eLibrary SPIN: 1431-5452, AuthorID: 150522, Scopus Author ID: 21739354400

S. A. Ivanov
https://new.nmicr.ru/mrrc/
A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Obninsk, Russian Federation Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation

Sergey A. Ivanov – Dr. Sci. (Medicine), Corresponding Member of the RAS, Director of A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Obninsk, Russian Federation; Professor of the Department of Oncology and Radiology named after V.P. Kharchenko at the Medical Institute, Peoples' Friendship University of Russia, Moscow, Russian Federation

ORCID: https://orcid.org/0000-0001-7689-6032, eLibrary SPIN: 4264-5167, AuthorID: 710405, Scopus Author ID: 16070399200, WoS ResearcherID: N-8221-2017

A. D. Kaprin
https://new.nmicr.ru
National Medical Research Radiological Centre, Obninsk, Russian Federation P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre, Moscow, Russian Federation Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation

Andrey D. Kaprin – Dr. Sci. (Medicine), Professor, Academician of the Russian Academy of Sciences, Academician of the Russian Academy of Education, Director of P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre, Moscow, Russian Federation, General Director of National Medical Research Radiological Centre, Obninsk, Russian Federation, Head of the Department of Oncology and Radiology named after V.P. Kharchenko at the Medical Institute, Peoples' Friendship University of Russia, Moscow, Russian Federation

ORCID: https://orcid.org/0000-0001-8784-8415, eLibrary SPIN: 1759-8101, AuthorID: 96775, Scopus Author ID: 6602709853, WoS ResearcherID: K-1445-2014

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