Original Articles. Mammalogy
Purpose. To develop and introduce into practice health facility individual programs of rehabilitation treatment and rehabilitation after combined treatment of breast cancer with the use of thermal imaging diagnostic method.
Materials and methods. The study included 259 women who had undergone combined treatment of breast cancer. The main contingent of the test (82.4%) were middle-aged women from 33 to 59 years old. For an objective diagnosis of the state of post-radiation fibrosis and scarring using modern methods of instrumental diagnostics: Sonoelastography, infrared thermography and thermal imaging diagnostics. In individual cases, to assess the developmental stages of lymphedema using lymphoscintigraphy and MRI.
Results. The proposed method of of research of the thermal state of postoperative functional area allows to identify disease and organic components in the form of scars and radiation fibrosis. This method allows to visualize the state of the heat balance on the surface of the skin and evaluate the impact of means of rehabilitation of the thermal regime of post-operative area. Critical thermal asymmetry increase by 2–3 degrees on Celsius indicates negative impact on homeostasis means of rehabilitation of post-operative area.
Conclusions. Thermal imaging diagnostics of scares, radiation damage and postmastectomy syndrome is a highly informative method of objective evaluation of the effectiveness of the rehabilitation process and can be recommended for use in specialized medical rehabilitation offices. For this, it developed adhesive-correcting method of prevention and treatment of late radiation damage, fibrosis, and keloids through innovative adhesive ekzoform. Develop a model structure and staffing with specialized rehabilitation rooms for women after combined treatment of breast cancer. Traditional means of rehabilitation (silicone-biological prosthetics) have a number of significant shortcomings in the form of discomfort from the displacement of the prosthesis – 33.6%, a heavy feeling of foreignness and – 43.3%, raising the temperature in the area of operational scar an average of 2.5 degrees. Innovative Rehabilitation (adhesive siliconebiological prosthetics) show a decrease in the incidence of edema of the hand to 8.3% – the emergence of the feeling of comfort and identity in 84.1% -providing reduce body temperature in the operating scar to normal values.
Original Articles. Gynecology
Despite the availability and informative value of methods that facilitate the diagnosis, cervical cancer (CC) does not lose its leading position as one of the most common cancers of the reproductive system in women worldwide. High prevalence of anemia and thrombotic complications in this group determines not only the quality of life of patients, but the outcome of the underlying disease.
The purpose of the study was to determine the patterns of change in erythrocyte of peripheral blood and the state of vascular-platelet and coagulation hemostasis in patients with cervical cancer depending on the stage of disease and histological variant of the tumor.
Materials and methods. We investigated the performance of erythron, thrombocytic and coagulation hemostasis in 74 patients with cervical cancer (mean age 46,49 ± 11,78 years). Blood analysis was performed in the initial evaluation of patients in the prehospital phase.
Results. It is proved that the spread of the tumor outside the cervix exerts a systemic influence on hematopoiesis, hemostasis, significantly increasing the risk of venous thromboembolism and hematogenous dissemination of the disease (metastasis). In the case of adenocarcinoma and dimorphic (glandular-squamous) cervical cancer we proved the significant increase in soluble fibrin-monomer complexes, fibrinogen, and with glandular-squamous-cell cervical cancer and hypercoagulability (decrease thrombin time), which requires mandatory and differentiated prevention of venous thromboembolism even in the early stages of these morphological variants of the disease.
Conclusions. Cervical cancer has a systemic effect on the blood and hemostasis. A statistically significant decrease in the concentration of hemoglobin and increased erythrocyte sedimentation rate is determined in the second stage of the disease. The increase in the prevalence of cervical cancer and the presence of glandular component in the morphological structure of the tumor was significantly associated with increased thrombosis.
Original Articles. Medical Practice
The actuality of the problem of high level of anxiety and the development of psycho-emotional disorders in women during pregnancy currently occupy a leading place in clinical practice. Pregnant "seize" the problem by using a non-adaptive coping and thereby form a similar pattern of behavior in stressful situation and in the fetus, perinatal-formed a similar pattern.
Materials and methods. Clinical-descriptive, formulated the concept of the influence psycho-emotional stress and characteristics of the current pregnancy on the background of
the formation of patterns of eating behavior in the fetus, followed by implementation after birth under the provisions of the dominant by A. A. Ukhtomsky, the theory of functional systems P. K. Anokhin, the endogeneity of the regularities of pathological processes, the pyramid of needs of A. Maslow.
Results. As a result of the establishment of the concept, doctors will be able to identify the maladaptive pattern of eating behavior in pregnant women and to make timely prevention of the formation of this pattern in the fetus.
Conclusion. The use of the developed concept could help doctors to identify the maladaptive pattern of eating behavior in pregnant women and make timely prevention of the formation of this pattern in the fetus.
Clinical Case Reports
Complications of tumor in patients with colorectal cancer are well known — a bowel obstruction, bleeding, perforation, tumor, liver failure, etc. Less common is a complication of massive intra-abdominal recurrence of colon cancer as the abdominal kompartment-syndrome or abdominal hypertension — rapid or gradual increase in intra-abdominal pressure to the further development of multiple organ failure. In this article we present a clinical case of surgical treatment of patients with metastatic colorectal cancer, complicated by intra-abdominal hypertension syndrome.
End-stage of chronic kidney disease adversely affects fetal and maternal outcomes during pregnancy. The last few years, advances in our knowledge about the interaction of pregnancy and renal function resulted in the improvement of fetal outcome in patients with chronic renal failure and also in the management of pregnant women with end-stage renal disease maintained on dialysis.
The article presents oncoplastic resection with the usage of the lower glandular stems. The article described a radical resection of the breast, to restore the lost volume gland they mobilize the lower glandular stem, including deepithelized glandular-adipose flap with nipple-areola complex. They described the indications and contraindications to this surgery. They give two clinical examples with a description of the options of transactions. Also they perform surgery on conntralateral breast to achieve good cosmetic results and symmetry.
Reviews, lectures
The review is devoted to modern notions about serum tumor markers and their place in oncology: using for differential diagnosis, in prognosis of course of tumor process, during follow-up, for preclinical detection of disease recurrences, as well as in screening aimed at early detection of malignant neoplasms. Algorithms of using of most informative tumor markers: CA125, HE4 (in ovarian cancer), PSA and its isoforms (in prostate cancer), iFOBT (in colorectal cancer) were described.
Renal cell carcinoma is the actual problem in the oncourological practice. The widespread use of methods of radiation diagnosis has increased the incidence of localized tumors of small size, which led to an increase in the number of patients who are indicated to perform organ preventive surgery. Kidney resection is an effective, relatively safe and commonly used method of the therapy in this contingent of patients. At the same time, the implementation of resection of the kidney is associated with need for the implementation of hemostasis during operations on active vascularized organ. Thus, adequate hemostasis is the most important phase of the operation at the time of resection of the kidney. The methodology aimed at the implementation of hemostasis diverse and include various means of mechanical, physical and chemical effects, aimed at vascularized parenchyma of the organ. The article presents a literature review covering different methods of hemostasis when performing a partial nephrectomy, presents the results of large studies aimed at evaluating various methods of hemostasis.
In this study of statistical data for the first time in Russia the analysis of the morbidity and mortality of patients with malignant neoplasms that may be associated with human papilloma virus (HPV) is performed: cervical cancer (cervical cancer), cancer of the vulva and vagina, cancer of penis, cancer of the rectum, anal canal and rectosigmoid junction cancer, cancer of the pharynx and larynx.
Организация здравоохранения
The article analyzes the mechanisms and technology management personnel professionalization of medical organizations. The question is now becoming even more relevant within the health care sector optimization, the main purpose of which is claimed to improve the quality of health care by improving the efficiency of health care organizations and their personnel, including the availability of physicians and medical staff, their skills and professionalism. The problems of improving the technology of postgraduate education of doctors examined.